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(2012). https://pubmed.ncbi.nlm.nih.gov/22534978/ DOI: 10.1039/c2mt20024d","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Proximal-tubule epithelial cells, apical membrane","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"1188f946-50fd-5cd8-b4aa-2de3ab2e046e","evidence_kind":"source_excerpt","locator":"Lines 344-355","start_line":344,"end_line":355,"excerpt":"### mn-trans-renal-dmt1\nDMT1-specific siRNA reduced apical manganese uptake in polarized mouse proximal-tubule cells.\nCondition category: machinery_impairment\nnutrient_topic: Manganese research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: DMT1 helped kidney-derived cells take up manganese from their lumen-facing side.\norganism: Mus musculus\ntissue_or_cell_type: Proximal-tubule epithelial cells, apical membrane\nexperimental_model: Transporter-specific siRNA in polarized mouse kidney proximal-tubule culture\nlimitations: Cell culture supports an uptake contribution; it does not quantify in vivo urinary reabsorption or rank transporter contributions.\nexposure: DMT1 siRNA versus controls during apical manganese exposure.\ncross_nutrient: false\n[mn-trans-22534978] Roles of ZIP8, ZIP14, and DMT1 in transport of cadmium and manganese in mouse kidney proximal tubule cells. 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