Component

Mouse AOM/DSS colorectal tumor burden

Context-specific entity; species, compartment and exposure are stated on each claim.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. In-vivo neutralization of LAP-expressing cells abolished CLA-associated tumor promotion.

    Mouse TGF-beta-producing macrophages and T cells → Mouse AOM/DSS colorectal tumor burden source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Mouse antibody-intervention experiment targeting latency-associated peptide-expressing cells.
    limitations
    Not equivalent to proving that every TGF-beta signal was blocked or identifying a human treatment.
    nutrient_topic
    CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
    plain_language
    Perturbing the TGF-beta-associated cell population changed the result.
    primary_references
    CLA-supplemented diet accelerates experimental colorectal cancer by inducing TGF-β-producing macrophages and T cells. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30279515/ · DOI 10.1038/s41385-018-0090-8

    Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 406–412

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Mouse antibody-intervention experiment targeting latency-associated peptide-expressing cells. · source_derived_draft · unverified_draft

    ## cla-tgf-neutralization Perturbing the TGF-beta-associated cell population changed the result. In-vivo neutralization of LAP-expressing cells abolished CLA-associated tumor promotion. Model: Mouse antibody-intervention experiment targeting latency-associated peptide-expressing cells. Limitations: Not equivalent to proving that every TGF-beta signal was blocked or identifying a human treatment. Evidence access: Primary abstract CLA-supplemented diet accelerates experimental colorectal cancer by inducing TGF-β-producing macrophages and T cells. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30279515/ · DOI 10.1038/s41385-018-0090-8
    Complete structured claim and evidence

  2. Macrophage-specific Pparg deletion abolished the CLA-associated protumorigenic effect.

    Mouse peroxisome proliferator-activated receptor gamma / Pparg → Mouse AOM/DSS colorectal tumor burden source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Conditional mouse knockout experiment.
    limitations
    Does not imply all PPAR-gamma activity promotes cancer.
    nutrient_topic
    CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
    plain_language
    The relevant cell type mattered to the tumor response.
    primary_references
    CLA-supplemented diet accelerates experimental colorectal cancer by inducing TGF-β-producing macrophages and T cells. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30279515/ · DOI 10.1038/s41385-018-0090-8

    Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 398–404

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Conditional mouse knockout experiment. · source_derived_draft · unverified_draft

    ## cla-tumor-macrophage-deletion The relevant cell type mattered to the tumor response. Macrophage-specific Pparg deletion abolished the CLA-associated protumorigenic effect. Model: Conditional mouse knockout experiment. Limitations: Does not imply all PPAR-gamma activity promotes cancer. Evidence access: Primary abstract CLA-supplemented diet accelerates experimental colorectal cancer by inducing TGF-β-producing macrophages and T cells. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30279515/ · DOI 10.1038/s41385-018-0090-8
    Complete structured claim and evidence

  3. CLA feeding worsened AOM/DSS tumor formation despite reducing acute DSS colitis.

    Study-specific mixed-isomer CLA preparations → Mouse AOM/DSS colorectal tumor burden source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Mouse colitis and colorectal-tumor models.
    limitations
    Opposite tumor direction to the earlier study; protocol/composition differences require comparison.
    nutrient_topic
    CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
    plain_language
    Reducing inflammation did not guarantee cancer protection.
    primary_references
    CLA-supplemented diet accelerates experimental colorectal cancer by inducing TGF-β-producing macrophages and T cells. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30279515/ · DOI 10.1038/s41385-018-0090-8

    Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 390–396

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Mouse colitis and colorectal-tumor models. · source_derived_draft · unverified_draft

    ## cla-tumor-promotion Reducing inflammation did not guarantee cancer protection. CLA feeding worsened AOM/DSS tumor formation despite reducing acute DSS colitis. Model: Mouse colitis and colorectal-tumor models. Limitations: Opposite tumor direction to the earlier study; protocol/composition differences require comparison. Evidence access: Primary abstract CLA-supplemented diet accelerates experimental colorectal cancer by inducing TGF-β-producing macrophages and T cells. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30279515/ · DOI 10.1038/s41385-018-0090-8
    Complete structured claim and evidence

  4. A 1% CLA diet reduced disease and adenocarcinoma formation in Pparg-expressing mice, but not mice lacking Pparg in immune and epithelial cells.

    Study-specific mixed-isomer CLA preparations → Mouse AOM/DSS colorectal tumor burden source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Azoxymethane followed by 2% DSS; tissue-specific Pparg deletion.
    limitations
    A later AOM/DSS study found tumor promotion; see the unresolved research disagreement.
    nutrient_topic
    CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
    plain_language
    One study found protection dependent on the regulator.
    primary_references
    Conjugated linoleic acid ameliorates inflammation-induced colorectal cancer in mice through activation of PPARgamma. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20089779/ · DOI 10.3945/jn.109.115642

    Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 382–388

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Azoxymethane followed by 2% DSS; tissue-specific Pparg deletion. · source_derived_draft · unverified_draft

    ## cla-tumor-protection One study found protection dependent on the regulator. A 1% CLA diet reduced disease and adenocarcinoma formation in Pparg-expressing mice, but not mice lacking Pparg in immune and epithelial cells. Model: Azoxymethane followed by 2% DSS; tissue-specific Pparg deletion. Limitations: A later AOM/DSS study found tumor promotion; see the unresolved research disagreement. Evidence access: Primary abstract Conjugated linoleic acid ameliorates inflammation-induced colorectal cancer in mice through activation of PPARgamma. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20089779/ · DOI 10.3945/jn.109.115642
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards