Component
Mouse TGF-beta-producing macrophages and T cells
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
In-vivo neutralization of LAP-expressing cells abolished CLA-associated tumor promotion.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Mouse antibody-intervention experiment targeting latency-associated peptide-expressing cells.
- limitations
- Not equivalent to proving that every TGF-beta signal was blocked or identifying a human treatment.
- nutrient_topic
- CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
- plain_language
- Perturbing the TGF-beta-associated cell population changed the result.
- primary_references
- CLA-supplemented diet accelerates experimental colorectal cancer by inducing TGF-β-producing macrophages and T cells. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30279515/ · DOI 10.1038/s41385-018-0090-8
Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 406–412
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Mouse antibody-intervention experiment targeting latency-associated peptide-expressing cells. · source_derived_draft · unverified_draft
## cla-tgf-neutralization Perturbing the TGF-beta-associated cell population changed the result. In-vivo neutralization of LAP-expressing cells abolished CLA-associated tumor promotion. Model: Mouse antibody-intervention experiment targeting latency-associated peptide-expressing cells. Limitations: Not equivalent to proving that every TGF-beta signal was blocked or identifying a human treatment. Evidence access: Primary abstract CLA-supplemented diet accelerates experimental colorectal cancer by inducing TGF-β-producing macrophages and T cells. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30279515/ · DOI 10.1038/s41385-018-0090-8
Complete structured claim and evidence
Where it participates (unsigned role)
Macrophage-specific Pparg deletion abolished the CLA-associated protumorigenic effect.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Conditional mouse knockout experiment.
- limitations
- Does not imply all PPAR-gamma activity promotes cancer.
- nutrient_topic
- CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
- plain_language
- The relevant cell type mattered to the tumor response.
- primary_references
- CLA-supplemented diet accelerates experimental colorectal cancer by inducing TGF-β-producing macrophages and T cells. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30279515/ · DOI 10.1038/s41385-018-0090-8
Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 398–404
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Conditional mouse knockout experiment. · source_derived_draft · unverified_draft
## cla-tumor-macrophage-deletion The relevant cell type mattered to the tumor response. Macrophage-specific Pparg deletion abolished the CLA-associated protumorigenic effect. Model: Conditional mouse knockout experiment. Limitations: Does not imply all PPAR-gamma activity promotes cancer. Evidence access: Primary abstract CLA-supplemented diet accelerates experimental colorectal cancer by inducing TGF-β-producing macrophages and T cells. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30279515/ · DOI 10.1038/s41385-018-0090-8
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.