{"id":"40f5561b-1f1e-57cf-9e5e-ce07b3ef843f","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-tumor-macrophage-deletion","predicate":"macrophage_deletion_abrogates","statement":"Macrophage-specific Pparg deletion abolished the CLA-associated protumorigenic effect.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"e6d5b1cb-c441-56c2-928b-9a8efff561c4","mechanism_event_label":"The relevant cell type mattered to the tumor response.","subject":{"id":"8e9622fd-f3a4-526b-9ab5-7389d768d937","slug":"mouse-pparg","display_name":"Mouse peroxisome proliferator-activated receptor gamma / Pparg","entity_type_key":"protein"},"object":{"id":"351f8854-621c-5287-9107-6637a331c128","slug":"mouse-aom-dss-tumor-burden","display_name":"Mouse AOM/DSS colorectal tumor burden","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e6d5b1cb-c441-56c2-928b-9a8efff561c4","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-tumor-macrophage-deletion-event","event_type":"observed_relationship","label":"The relevant cell type mattered to the tumor response.","description":"Macrophage-specific Pparg deletion abolished the CLA-associated protumorigenic effect.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8e9622fd-f3a4-526b-9ab5-7389d768d937","slug":"mouse-pparg","display_name":"Mouse peroxisome proliferator-activated receptor gamma / Pparg","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"351f8854-621c-5287-9107-6637a331c128","slug":"mouse-aom-dss-tumor-burden","display_name":"Mouse AOM/DSS colorectal tumor burden","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"6f0cf7bd-c6e5-52d1-92f8-dd5c879e3c57","slug":"cla-mixed-isomer-preparations","display_name":"Study-specific mixed-isomer CLA preparations","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"8c1ce843-8860-515c-bd7d-902529008e35","slug":"mouse-tgf-beta-producing-immune-cells","display_name":"Mouse TGF-beta-producing macrophages and T cells","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Conditional mouse knockout experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not imply all PPAR-gamma activity promotes cancer.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"CLA collection; 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