Component
Mouse 5-HT3 receptor-channel complex
Native N1E-115-cell 5-HT3 channel; subunit composition unresolved in the accessed source.
3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
10-Gingerol inhibited 5-HT3-mediated cation influx in N1E-115 cells.
Experimental context and source evidence
- dose
- Concentration-dependent gingerol application; exact range not in accessed abstract
- duration
- Not specified in accessed abstract
- evidence_access
- Primary PubMed abstract.
- evidence_scope
- literature_reviewed; model-specific source-derived curation, not universally established human effects
- experimental_model
- Mouse N1E-115 neuroblastoma cells
- limitations
- Cation flux is a functional assay, not a demonstrated orthosteric binding site or clinical antiemetic response.
- nutrient_topic
- Gingerols collection; each molecular form and experimental preparation remains explicit. · Gingerols
- organism
- Mouse N1E-115 neuroblastoma cells
- plain_language
- 10-Gingerol inhibited 5-HT3-mediated cation influx in N1E-115 cells.
- primary_references
- Mode of action of gingerols and shogaols on 5-HT3 receptors: binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum. (2006). https://pubmed.ncbi.nlm.nih.gov/16364290/ DOI: 10.1016/j.ejphar.2005.10.049
- route
- In vitro addition
- tissue
- Native 5-HT3 receptor-channel complex
Gingerols: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 118–127
Original AI-assisted curation of thirteen primary research papers; study-specific PubMed/DOI links and limitations retained. Not publisher full text. · supports · Mouse N1E-115 neuroblastoma cells · source_derived_draft · unverified_draft
## gingerols-10-5ht3-flux 10-Gingerol inhibited 5-HT3-mediated cation influx in N1E-115 cells. Model/species: Mouse N1E-115 neuroblastoma cells Tissue: Native 5-HT3 receptor-channel complex Exposure: Concentration-dependent gingerol application; exact range not in accessed abstract Route: In vitro addition Duration: Not specified in accessed abstract Limits: Cation flux is a functional assay, not a demonstrated orthosteric binding site or clinical antiemetic response. Primary reference: Mode of action of gingerols and shogaols on 5-HT3 receptors: binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum. (2006). https://pubmed.ncbi.nlm.nih.gov/16364290/ DOI: 10.1016/j.ejphar.2005.10.049 Access: Primary PubMed abstract.
Complete structured claim and evidence6-Gingerol inhibited 5-HT3-mediated cation influx in N1E-115 cells.
Experimental context and source evidence
- dose
- Concentration-dependent gingerol application; exact range not in accessed abstract
- duration
- Not specified in accessed abstract
- evidence_access
- Primary PubMed abstract.
- evidence_scope
- literature_reviewed; model-specific source-derived curation, not universally established human effects
- experimental_model
- Mouse N1E-115 neuroblastoma cells
- limitations
- Cation flux is a functional assay, not a demonstrated orthosteric binding site or clinical antiemetic response.
- nutrient_topic
- Gingerols collection; each molecular form and experimental preparation remains explicit. · Gingerols
- organism
- Mouse N1E-115 neuroblastoma cells
- plain_language
- 6-Gingerol inhibited 5-HT3-mediated cation influx in N1E-115 cells.
- primary_references
- Mode of action of gingerols and shogaols on 5-HT3 receptors: binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum. (2006). https://pubmed.ncbi.nlm.nih.gov/16364290/ DOI: 10.1016/j.ejphar.2005.10.049
- route
- In vitro addition
- tissue
- Native 5-HT3 receptor-channel complex
Gingerols: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 52–61
Original AI-assisted curation of thirteen primary research papers; study-specific PubMed/DOI links and limitations retained. Not publisher full text. · supports · Mouse N1E-115 neuroblastoma cells · source_derived_draft · unverified_draft
## gingerols-6-5ht3-flux 6-Gingerol inhibited 5-HT3-mediated cation influx in N1E-115 cells. Model/species: Mouse N1E-115 neuroblastoma cells Tissue: Native 5-HT3 receptor-channel complex Exposure: Concentration-dependent gingerol application; exact range not in accessed abstract Route: In vitro addition Duration: Not specified in accessed abstract Limits: Cation flux is a functional assay, not a demonstrated orthosteric binding site or clinical antiemetic response. Primary reference: Mode of action of gingerols and shogaols on 5-HT3 receptors: binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum. (2006). https://pubmed.ncbi.nlm.nih.gov/16364290/ DOI: 10.1016/j.ejphar.2005.10.049 Access: Primary PubMed abstract.
Complete structured claim and evidence8-Gingerol inhibited 5-HT3-mediated cation influx in N1E-115 cells.
Experimental context and source evidence
- dose
- Concentration-dependent gingerol application; exact range not in accessed abstract
- duration
- Not specified in accessed abstract
- evidence_access
- Primary PubMed abstract.
- evidence_scope
- literature_reviewed; model-specific source-derived curation, not universally established human effects
- experimental_model
- Mouse N1E-115 neuroblastoma cells
- limitations
- Cation flux is a functional assay, not a demonstrated orthosteric binding site or clinical antiemetic response.
- nutrient_topic
- Gingerols collection; each molecular form and experimental preparation remains explicit. · Gingerols
- organism
- Mouse N1E-115 neuroblastoma cells
- plain_language
- 8-Gingerol inhibited 5-HT3-mediated cation influx in N1E-115 cells.
- primary_references
- Mode of action of gingerols and shogaols on 5-HT3 receptors: binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum. (2006). https://pubmed.ncbi.nlm.nih.gov/16364290/ DOI: 10.1016/j.ejphar.2005.10.049
- route
- In vitro addition
- tissue
- Native 5-HT3 receptor-channel complex
Gingerols: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 85–94
Original AI-assisted curation of thirteen primary research papers; study-specific PubMed/DOI links and limitations retained. Not publisher full text. · supports · Mouse N1E-115 neuroblastoma cells · source_derived_draft · unverified_draft
## gingerols-8-5ht3-flux 8-Gingerol inhibited 5-HT3-mediated cation influx in N1E-115 cells. Model/species: Mouse N1E-115 neuroblastoma cells Tissue: Native 5-HT3 receptor-channel complex Exposure: Concentration-dependent gingerol application; exact range not in accessed abstract Route: In vitro addition Duration: Not specified in accessed abstract Limits: Cation flux is a functional assay, not a demonstrated orthosteric binding site or clinical antiemetic response. Primary reference: Mode of action of gingerols and shogaols on 5-HT3 receptors: binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum. (2006). https://pubmed.ncbi.nlm.nih.gov/16364290/ DOI: 10.1016/j.ejphar.2005.10.049 Access: Primary PubMed abstract.
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.