Component
Mitochondrial lipoamide dehydrogenases, species unspecified
Mitochondrial lipoamide dehydrogenases, species unspecified. Species, exposure and limitations are retained in each linked claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
The tested lipoamide dehydrogenase reduced R-lipoic acid about 28 times faster than S-lipoic acid.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/ala-research/8573188.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7631d83a60fe421318384db96c5b92458c21b0e3aeadaff85c7ae60223e40976", "start_char": 0, "end_char": 809, "text_sha256": "7631d83a60fe421318384db96c5b92458c21b0e3aeadaff85c7ae60223e40976"}
- experimental_model
- Purified mitochondrial lipoamide dehydrogenase stereoselectivity assays
- exposure
- R/S lipoic acid and metabolites
- limitations
- Do not equate the enzyme-family result with a specific human DLD preparation or whole-person clinical superiority.
- nutrient_topic
- Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect. · Lipoic acid
- organism
- Species not identified in indexed abstract
- plain_language
- The two mirror-image forms were not equivalent substrates for this enzyme.
- primary_references
- [ala-p8573188] Reduction of lipoic acid by lipoamide dehydrogenase. (1996). https://pubmed.ncbi.nlm.nih.gov/8573188/ DOI: 10.1016/0006-2952(95)02124-8
- tissue_or_cell_type
- Purified mitochondrial enzyme
Alpha-lipoic acid: cofactor assembly, redox signaling and nutrient interactions (2026-09-17) · lines 767–778
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purified mitochondrial lipoamide dehydrogenase stereoselectivity assays · source_derived_draft · unverified_draft
### ala-lipdh-r-selectivity The tested lipoamide dehydrogenase reduced R-lipoic acid about 28 times faster than S-lipoic acid. Condition category: normal nutrient_topic: Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: The two mirror-image forms were not equivalent substrates for this enzyme. organism: Species not identified in indexed abstract tissue_or_cell_type: Purified mitochondrial enzyme experimental_model: Purified mitochondrial lipoamide dehydrogenase stereoselectivity assays limitations: Do not equate the enzyme-family result with a specific human DLD preparation or whole-person clinical superiority. exposure: R/S lipoic acid and metabolites evidence_span: {"source_cache": "artifacts/ala-research/8573188.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7631d83a60fe421318384db96c5b92458c21b0e3aeadaff85c7ae60223e40976", "start_char": 0, "end_char": 809, "text_sha256": "7631d83a60fe421318384db96c5b92458c21b0e3aeadaff85c7ae60223e40976"} [ala-p8573188] Reduction of lipoic acid by lipoamide dehydrogenase. (1996). https://pubmed.ncbi.nlm.nih.gov/8573188/ DOI: 10.1016/0006-2952(95)02124-8
Complete structured claim and evidence
Where it participates (unsigned role)
S-lipoic acid inhibited R-lipoic-acid reduction only at high concentrations in the enzyme assay.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/ala-research/8573188.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7631d83a60fe421318384db96c5b92458c21b0e3aeadaff85c7ae60223e40976", "start_char": 0, "end_char": 809, "text_sha256": "7631d83a60fe421318384db96c5b92458c21b0e3aeadaff85c7ae60223e40976"}
- experimental_model
- Purified mitochondrial lipoamide dehydrogenase stereoselectivity assays
- exposure
- R/S lipoic acid and metabolites
- limitations
- Do not equate the enzyme-family result with a specific human DLD preparation or whole-person clinical superiority.
- nutrient_topic
- Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect. · Lipoic acid
- organism
- Species not identified in indexed abstract
- plain_language
- Competition appeared under particular assay conditions, not as proof that ordinary racemic supplements block the pathway.
- primary_references
- [ala-p8573188] Reduction of lipoic acid by lipoamide dehydrogenase. (1996). https://pubmed.ncbi.nlm.nih.gov/8573188/ DOI: 10.1016/0006-2952(95)02124-8
- tissue_or_cell_type
- Purified mitochondrial enzyme
Alpha-lipoic acid: cofactor assembly, redox signaling and nutrient interactions (2026-09-17) · lines 780–791
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purified mitochondrial lipoamide dehydrogenase stereoselectivity assays · source_derived_draft · unverified_draft
### ala-s-high-concentration-inhibition S-lipoic acid inhibited R-lipoic-acid reduction only at high concentrations in the enzyme assay. Condition category: normal nutrient_topic: Alpha-lipoic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: Competition appeared under particular assay conditions, not as proof that ordinary racemic supplements block the pathway. organism: Species not identified in indexed abstract tissue_or_cell_type: Purified mitochondrial enzyme experimental_model: Purified mitochondrial lipoamide dehydrogenase stereoselectivity assays limitations: Do not equate the enzyme-family result with a specific human DLD preparation or whole-person clinical superiority. exposure: R/S lipoic acid and metabolites evidence_span: {"source_cache": "artifacts/ala-research/8573188.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7631d83a60fe421318384db96c5b92458c21b0e3aeadaff85c7ae60223e40976", "start_char": 0, "end_char": 809, "text_sha256": "7631d83a60fe421318384db96c5b92458c21b0e3aeadaff85c7ae60223e40976"} [ala-p8573188] Reduction of lipoic acid by lipoamide dehydrogenase. (1996). https://pubmed.ncbi.nlm.nih.gov/8573188/ DOI: 10.1016/0006-2952(95)02124-8
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.