Component

Luteolin monoglucuronides, position unresolved in study

Context-specific entity; species, compartment and exposure are stated on each claim.

7 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Ko143 inhibition of ABCG2 reduced luteolin-monoglucuronide efflux and increased intracellular retention.

    Human ABCG2 / breast cancer resistance protein → Luteolin monoglucuronides, position unresolved in study source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary abstract
    experimental_model
    UGT1A9-expressing human HeLa cells.
    limitations
    Pharmacological inhibition; diglucuronide compensation was proposed, not proven in patients.
    nutrient_topic
    Luteolin collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Luteolin / 3′,4′,5,7-tetrahydroxyflavone
    plain_language
    Blocking export changes where metabolites accumulate.
    primary_references
    Breast cancer resistance protein-mediated efflux of luteolin glucuronides in HeLa cells overexpressing UDP-glucuronosyltransferase 1A9. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24092055/ · DOI 10.1007/s11095-013-1207-0
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Luteolin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19) · lines 84–90

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · UGT1A9-expressing human HeLa cells. · source_derived_draft · unverified_draft

    ## luteolin-abcg2-blockade Blocking export changes where metabolites accumulate. Ko143 inhibition of ABCG2 reduced luteolin-monoglucuronide efflux and increased intracellular retention. Model: UGT1A9-expressing human HeLa cells. Limitations: Pharmacological inhibition; diglucuronide compensation was proposed, not proven in patients. Evidence access: Primary abstract Breast cancer resistance protein-mediated efflux of luteolin glucuronides in HeLa cells overexpressing UDP-glucuronosyltransferase 1A9. · 2014 · https://pubmed.ncbi.nlm.nih.gov/24092055/ · DOI 10.1007/s11095-013-1207-0
    Complete structured claim and evidence

  2. LPS-treated rats showed increased plasma beta-glucuronidase activity and a higher free-luteolin/monoglucuronide ratio.

    Luteolin / 3′,4′,5,7-tetrahydroxyflavone → Luteolin monoglucuronides, position unresolved in study source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    evidence_access
    Primary abstract
    experimental_model
    Rat intravenous LPS experiment.
    limitations
    Association supports deconjugation; not a universal human targeting mechanism.
    nutrient_topic
    Luteolin collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Luteolin / 3′,4′,5,7-tetrahydroxyflavone
    plain_language
    Inflammatory state altered measured forms.
    primary_references
    Deglucuronidation of a flavonoid, luteolin monoglucuronide, during inflammation. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11717168/
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Luteolin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19) · lines 164–170

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Rat intravenous LPS experiment. · source_derived_draft · unverified_draft

    ## luteolin-rat-deconjugation Inflammatory state altered measured forms. LPS-treated rats showed increased plasma beta-glucuronidase activity and a higher free-luteolin/monoglucuronide ratio. Model: Rat intravenous LPS experiment. Limitations: Association supports deconjugation; not a universal human targeting mechanism. Evidence access: Primary abstract Deglucuronidation of a flavonoid, luteolin monoglucuronide, during inflammation. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11717168/
    Complete structured claim and evidence

  3. Rats given luteolin aglycone or the tested glucosides predominantly contained glucuronides in plasma and organs.

    Luteolin / 3′,4′,5,7-tetrahydroxyflavone → Luteolin monoglucuronides, position unresolved in study source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Rat oral aglycone and green-pepper-leaf glucosides.
    limitations
    Species and administered form affect exposure. The glucuronide pool is not a single positional isomer.
    nutrient_topic
    Luteolin collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Luteolin / 3′,4′,5,7-tetrahydroxyflavone
    plain_language
    Rat metabolism cannot be copied directly onto humans.
    primary_references
    Absorption and Metabolism of Luteolin in Rats and Humans in Relation to in Vitro Anti-inflammatory Effects. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30280574/ · DOI 10.1021/acs.jafc.8b03273

    Luteolin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19) · lines 20–26

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Rat oral aglycone and green-pepper-leaf glucosides. · source_derived_draft · unverified_draft

    ## luteolin-rat-glucuronides Rat metabolism cannot be copied directly onto humans. Rats given luteolin aglycone or the tested glucosides predominantly contained glucuronides in plasma and organs. Model: Rat oral aglycone and green-pepper-leaf glucosides. Limitations: Species and administered form affect exposure. The glucuronide pool is not a single positional isomer. Evidence access: Primary abstract Absorption and Metabolism of Luteolin in Rats and Humans in Relation to in Vitro Anti-inflammatory Effects. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30280574/ · DOI 10.1021/acs.jafc.8b03273
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Supernatants from activated human neutrophils converted luteolin monoglucuronide to free luteolin, consistent with released beta-glucuronidase.

    Human beta-glucuronidase / GUSB → Luteolin / 3′,4′,5,7-tetrahydroxyflavone source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Ionomycin/cytochalasin-B-stimulated human neutrophils; HPLC.
    limitations
    Position of the monoglucuronide is not resolved in the abstract.
    nutrient_topic
    Luteolin collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Luteolin / 3′,4′,5,7-tetrahydroxyflavone
    plain_language
    Inflamed cells can locally regenerate the unconjugated molecule.
    primary_references
    Deglucuronidation of a flavonoid, luteolin monoglucuronide, during inflammation. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11717168/

    Luteolin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19) · lines 156–162

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Ionomycin/cytochalasin-B-stimulated human neutrophils; HPLC. · source_derived_draft · unverified_draft

    ## luteolin-neutrophil-release Inflamed cells can locally regenerate the unconjugated molecule. Supernatants from activated human neutrophils converted luteolin monoglucuronide to free luteolin, consistent with released beta-glucuronidase. Model: Ionomycin/cytochalasin-B-stimulated human neutrophils; HPLC. Limitations: Position of the monoglucuronide is not resolved in the abstract. Evidence access: Primary abstract Deglucuronidation of a flavonoid, luteolin monoglucuronide, during inflammation. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11717168/
    Complete structured claim and evidence

  2. Recombinant human UGT1A1 efficiently glucuronidated luteolin in the isoenzyme comparison.

    Human UDP-glucuronosyltransferase 1A1 / UGT1A1 → Luteolin / 3′,4′,5,7-tetrahydroxyflavone source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human recombinant UGT comparison and microsomes.
    limitations
    Relative activity depends on tissue and conjugation position. Not a claim of equal in-vivo contribution.
    nutrient_topic
    Luteolin collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Luteolin / 3′,4′,5,7-tetrahydroxyflavone
    plain_language
    A specific enzyme can attach a glucuronide group.
    primary_references
    Regioselectivity of phase II metabolism of luteolin and quercetin by UDP-glucuronosyl transferases. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12018987/ · DOI 10.1021/tx0101705

    Luteolin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19) · lines 28–34

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Human recombinant UGT comparison and microsomes. · source_derived_draft · unverified_draft

    ## luteolin-ugt1a1-formation A specific enzyme can attach a glucuronide group. Recombinant human UGT1A1 efficiently glucuronidated luteolin in the isoenzyme comparison. Model: Human recombinant UGT comparison and microsomes. Limitations: Relative activity depends on tissue and conjugation position. Not a claim of equal in-vivo contribution. Evidence access: Primary abstract Regioselectivity of phase II metabolism of luteolin and quercetin by UDP-glucuronosyl transferases. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12018987/ · DOI 10.1021/tx0101705
    Complete structured claim and evidence

  3. Recombinant human UGT1A8 efficiently glucuronidated luteolin in the isoenzyme comparison.

    Human UGT1A8 → Luteolin / 3′,4′,5,7-tetrahydroxyflavone source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human recombinant UGT comparison and microsomes.
    limitations
    Relative activity depends on tissue and conjugation position. Not a claim of equal in-vivo contribution.
    nutrient_topic
    Luteolin collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Luteolin / 3′,4′,5,7-tetrahydroxyflavone
    plain_language
    A specific enzyme can attach a glucuronide group.
    primary_references
    Regioselectivity of phase II metabolism of luteolin and quercetin by UDP-glucuronosyl transferases. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12018987/ · DOI 10.1021/tx0101705

    Luteolin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19) · lines 36–42

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Human recombinant UGT comparison and microsomes. · source_derived_draft · unverified_draft

    ## luteolin-ugt1a8-formation A specific enzyme can attach a glucuronide group. Recombinant human UGT1A8 efficiently glucuronidated luteolin in the isoenzyme comparison. Model: Human recombinant UGT comparison and microsomes. Limitations: Relative activity depends on tissue and conjugation position. Not a claim of equal in-vivo contribution. Evidence access: Primary abstract Regioselectivity of phase II metabolism of luteolin and quercetin by UDP-glucuronosyl transferases. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12018987/ · DOI 10.1021/tx0101705
    Complete structured claim and evidence

  4. Recombinant human UGT1A9 efficiently glucuronidated luteolin in the isoenzyme comparison.

    Human UDP-glucuronosyltransferase 1A9 / UGT1A9 → Luteolin / 3′,4′,5,7-tetrahydroxyflavone source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human recombinant UGT comparison and microsomes.
    limitations
    Relative activity depends on tissue and conjugation position. Not a claim of equal in-vivo contribution.
    nutrient_topic
    Luteolin collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Luteolin / 3′,4′,5,7-tetrahydroxyflavone
    plain_language
    A specific enzyme can attach a glucuronide group.
    primary_references
    Regioselectivity of phase II metabolism of luteolin and quercetin by UDP-glucuronosyl transferases. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12018987/ · DOI 10.1021/tx0101705

    Luteolin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19) · lines 44–50

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Human recombinant UGT comparison and microsomes. · source_derived_draft · unverified_draft

    ## luteolin-ugt1a9-formation A specific enzyme can attach a glucuronide group. Recombinant human UGT1A9 efficiently glucuronidated luteolin in the isoenzyme comparison. Model: Human recombinant UGT comparison and microsomes. Limitations: Relative activity depends on tissue and conjugation position. Not a claim of equal in-vivo contribution. Evidence access: Primary abstract Regioselectivity of phase II metabolism of luteolin and quercetin by UDP-glucuronosyl transferases. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12018987/ · DOI 10.1021/tx0101705
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

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