{"id":"6b092842-9546-5a90-9496-13ac3a8f17cc","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-rat-deconjugation","predicate":"inflammatory_context_increases_free_ratio","statement":"LPS-treated rats showed increased plasma beta-glucuronidase activity and a higher free-luteolin/monoglucuronide ratio.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"34a6ca07-efbb-5cef-ad4b-fb8016d2300c","mechanism_event_label":"Inflammatory state altered measured forms.","subject":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"object":{"id":"f0186989-65b0-5f7a-95d9-d25a7789222b","slug":"luteolin-monoglucuronides","display_name":"Luteolin monoglucuronides, position unresolved in study","entity_type_key":"chemical_species"},"evidence_count":1,"mechanism_event":{"id":"34a6ca07-efbb-5cef-ad4b-fb8016d2300c","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-rat-deconjugation-event","event_type":"observed_relationship","label":"Inflammatory state altered measured forms.","description":"LPS-treated rats showed increased plasma beta-glucuronidase activity and a higher free-luteolin/monoglucuronide ratio.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f0186989-65b0-5f7a-95d9-d25a7789222b","slug":"luteolin-monoglucuronides","display_name":"Luteolin monoglucuronides, position unresolved in study","entity_type_key":"chemical_species"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat intravenous LPS experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Association supports deconjugation; not a universal human targeting mechanism.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Luteolin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Inflammatory state altered measured forms.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Deglucuronidation of a flavonoid, luteolin monoglucuronide, during inflammation. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11717168/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"091e30ab-2494-55be-9a36-e753a4f33256","evidence_kind":"source_excerpt","locator":"Lines 164-170","start_line":164,"end_line":170,"excerpt":"## luteolin-rat-deconjugation\nInflammatory state altered measured forms.\nLPS-treated rats showed increased plasma beta-glucuronidase activity and a higher free-luteolin/monoglucuronide ratio.\nModel: Rat intravenous LPS experiment.\nLimitations: Association supports deconjugation; not a universal human targeting mechanism.\nEvidence access: Primary abstract\nDeglucuronidation of a flavonoid, luteolin monoglucuronide, during inflammation. · 2001 · https://pubmed.ncbi.nlm.nih.gov/11717168/","model_system":"Rat intravenous LPS experiment.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"26337a08-5cee-5cee-900e-e6d3e26ac6e4","stable_key":"import-22527305-af1f-536a-b419-7e73f08cc3ec","title":"Luteolin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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