{"id":"2bbca753-a62a-5c49-af14-44e581cbaf57","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-ugt1a9-formation","predicate":"glucuronidates","statement":"Recombinant human UGT1A9 efficiently glucuronidated luteolin in the isoenzyme comparison.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"f21a4ae6-5aac-549c-b408-4ba5a75825b6","mechanism_event_label":"A specific enzyme can attach a glucuronide group.","subject":{"id":"0721c8f5-4c36-500f-9df4-f34e5eeaadba","slug":"ugt1a9","display_name":"Human UDP-glucuronosyltransferase 1A9 / UGT1A9","entity_type_key":"protein"},"object":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"f21a4ae6-5aac-549c-b408-4ba5a75825b6","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-ugt1a9-formation-event","event_type":"observed_relationship","label":"A specific enzyme can attach a glucuronide group.","description":"Recombinant human UGT1A9 efficiently glucuronidated luteolin in the isoenzyme comparison.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0721c8f5-4c36-500f-9df4-f34e5eeaadba","slug":"ugt1a9","display_name":"Human UDP-glucuronosyltransferase 1A9 / UGT1A9","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"fea4f3f0-7c05-59a2-9332-445b9d4f8fb0","slug":"udp-glucuronic-acid","display_name":"UDP-glucuronic acid","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"f0186989-65b0-5f7a-95d9-d25a7789222b","slug":"luteolin-monoglucuronides","display_name":"Luteolin monoglucuronides, position unresolved in study","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human recombinant UGT comparison and microsomes.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Relative activity depends on tissue and conjugation position. Not a claim of equal in-vivo contribution.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Luteolin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A specific enzyme can attach a glucuronide group.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Regioselectivity of phase II metabolism of luteolin and quercetin by UDP-glucuronosyl transferases. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12018987/ · DOI 10.1021/tx0101705","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0652e215-37b1-5905-bdc6-775e95d15f40","evidence_kind":"source_excerpt","locator":"Lines 44-50","start_line":44,"end_line":50,"excerpt":"## luteolin-ugt1a9-formation\nA specific enzyme can attach a glucuronide group.\nRecombinant human UGT1A9 efficiently glucuronidated luteolin in the isoenzyme comparison.\nModel: Human recombinant UGT comparison and microsomes.\nLimitations: Relative activity depends on tissue and conjugation position. Not a claim of equal in-vivo contribution.\nEvidence access: Primary abstract\nRegioselectivity of phase II metabolism of luteolin and quercetin by UDP-glucuronosyl transferases. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12018987/ · DOI 10.1021/tx0101705","model_system":"Human recombinant UGT comparison and microsomes.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"26337a08-5cee-5cee-900e-e6d3e26ac6e4","stable_key":"import-22527305-af1f-536a-b419-7e73f08cc3ec","title":"Luteolin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"fd6ea0b1cef8d1c9965270494bfa815de14f679044f0b5d5d7bbf4904630ad76","revision_id":"c9a3dd80-c7e6-5fb4-bc91-8db265e7c8de","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}