{"id":"9e31b29b-1887-599e-b309-4499059589ab","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-rat-glucuronides","predicate":"oral_administration_yields","statement":"Rats given luteolin aglycone or the tested glucosides predominantly contained glucuronides in plasma and organs.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"518d5045-4969-55ff-9904-c6c88b10cb6c","mechanism_event_label":"Rat metabolism cannot be copied directly onto humans.","subject":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"object":{"id":"f0186989-65b0-5f7a-95d9-d25a7789222b","slug":"luteolin-monoglucuronides","display_name":"Luteolin monoglucuronides, position unresolved in study","entity_type_key":"chemical_species"},"evidence_count":1,"mechanism_event":{"id":"518d5045-4969-55ff-9904-c6c88b10cb6c","stable_key":"22527305-af1f-536a-b419-7e73f08cc3ec:luteolin-rat-glucuronides-event","event_type":"observed_relationship","label":"Rat metabolism cannot be copied directly onto humans.","description":"Rats given luteolin aglycone or the tested glucosides predominantly contained glucuronides in plasma and organs.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"80472c4b-ecc2-52e3-a766-f8463294774f","slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f0186989-65b0-5f7a-95d9-d25a7789222b","slug":"luteolin-monoglucuronides","display_name":"Luteolin monoglucuronides, position unresolved in study","entity_type_key":"chemical_species"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"47b0cd22-95db-58d3-87e2-2c07c883a804","slug":"luteolin-7-o-glucoside","display_name":"Luteolin 7-O-glucoside","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat oral aglycone and green-pepper-leaf glucosides.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Species and administered form affect exposure. The glucuronide pool is not a single positional isomer.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Luteolin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"luteolin","display_name":"Luteolin / 3′,4′,5,7-tetrahydroxyflavone","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Rat metabolism cannot be copied directly onto humans.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Absorption and Metabolism of Luteolin in Rats and Humans in Relation to in Vitro Anti-inflammatory Effects. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30280574/ · DOI 10.1021/acs.jafc.8b03273","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"5d8d16ef-750c-53e5-9877-b4b4f94c0d13","evidence_kind":"source_excerpt","locator":"Lines 20-26","start_line":20,"end_line":26,"excerpt":"## luteolin-rat-glucuronides\nRat metabolism cannot be copied directly onto humans.\nRats given luteolin aglycone or the tested glucosides predominantly contained glucuronides in plasma and organs.\nModel: Rat oral aglycone and green-pepper-leaf glucosides.\nLimitations: Species and administered form affect exposure. The glucuronide pool is not a single positional isomer.\nEvidence access: Primary abstract\nAbsorption and Metabolism of Luteolin in Rats and Humans in Relation to in Vitro Anti-inflammatory Effects. · 2018 · https://pubmed.ncbi.nlm.nih.gov/30280574/ · DOI 10.1021/acs.jafc.8b03273","model_system":"Rat oral aglycone and green-pepper-leaf glucosides.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"26337a08-5cee-5cee-900e-e6d3e26ac6e4","stable_key":"import-22527305-af1f-536a-b419-7e73f08cc3ec","title":"Luteolin: metabolism, immune signaling, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"fd6ea0b1cef8d1c9965270494bfa815de14f679044f0b5d5d7bbf4904630ad76","revision_id":"c9a3dd80-c7e6-5fb4-bc91-8db265e7c8de","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}