Component
Hypothiocyanite / OSCN−
Hypothiocyanite / OSCN−. Species, exposure and limitations are retained in each linked claim.
3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Salivary thiocyanate and hypothiocyanite did not significantly change after contrast exposure.
Experimental context and source evidence
- experimental_model
- Paired saliva measurements in 40 coronary-angiography patients exposed to iodinated contrast.
- exposure_category
- Study-specific exposure, including pharmacological and in-vitro conditions; normal is the schema fallback outside the three availability categories.
- limitations
- Contrast exposure is not oral KI; observational chemistry endpoints do not establish infection prevention or a safe effective supplement dose.
- nutrient_topic
- Potassium iodide research collection; shared-anion and comparator studies are not all KI interventions. · Potassium iodide
- plain_language
- Not every component of the defence system increased.
- primary_references
- Excess iodine exposure acutely increases salivary iodide and antimicrobial hypoiodous acid concentrations in humans. · 2022 · https://pubmed.ncbi.nlm.nih.gov/36463312/ · DOI 10.1038/s41598-022-23803-8
Potassium iodide: thyroid and non-thyroid mechanisms, interactions and discovery questions (2026-09-18) · lines 176–182
AI-assisted research curation; primary-study references, chemical references and label statements individually identified. Not publisher full text. · supports · Paired saliva measurements in 40 coronary-angiography patients exposed to iodinated contrast. · source_derived_draft · unverified_draft
## ki-saliva-null Not every component of the defence system increased. Salivary thiocyanate and hypothiocyanite did not significantly change after contrast exposure. Model: Paired saliva measurements in 40 coronary-angiography patients exposed to iodinated contrast. Limitations: Contrast exposure is not oral KI; observational chemistry endpoints do not establish infection prevention or a safe effective supplement dose. Evidence location: Primary abstract Excess iodine exposure acutely increases salivary iodide and antimicrobial hypoiodous acid concentrations in humans. · 2022 · https://pubmed.ncbi.nlm.nih.gov/36463312/ · DOI 10.1038/s41598-022-23803-8
Complete structured claim and evidence
Where it participates (unsigned role)
Myeloperoxidase favored thiocyanate kinetically and generated hypothiocyanite despite 100 mM chloride.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/chloride-research/9359420.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "83dc6a264dfb45201104568ac58c76509aaa0fabca1f32efd25861146b4b38c0", "start_char": 0, "end_char": 1700, "text_sha256": "83dc6a264dfb45201104568ac58c76509aaa0fabca1f32efd25861146b4b38c0"}
- experimental_model
- Purified-enzyme substrate kinetics
- exposure
- 100 mM chloride with varying thiocyanate
- limitations
- Product chemistry under assay conditions; not a recommendation to raise chloride or thiocyanate intake.
- nutrient_topic
- Chloride research collection; topical membership is not evidence of a direct dietary effect. · Chloride
- organism
- Human neutrophil enzyme
- plain_language
- An abundant chloride pool does not mean it is the enzyme’s only substrate.
- primary_references
- [chloride-p9359420] Thiocyanate and chloride as competing substrates for myeloperoxidase. (1997). https://pubmed.ncbi.nlm.nih.gov/9359420/ DOI: 10.1042/bj3270487
- tissue_or_cell_type
- Myeloperoxidase reaction mixture
Chloride: transport, acid-base balance, nutrient interactions and loss states (2026-09-17) · lines 627–638
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Purified-enzyme substrate kinetics · source_derived_draft · unverified_draft
### chloride-mpo-thiocyanate Myeloperoxidase favored thiocyanate kinetically and generated hypothiocyanite despite 100 mM chloride. Condition category: normal nutrient_topic: Chloride research collection; topical membership is not evidence of a direct dietary effect. plain_language: An abundant chloride pool does not mean it is the enzyme’s only substrate. organism: Human neutrophil enzyme tissue_or_cell_type: Myeloperoxidase reaction mixture experimental_model: Purified-enzyme substrate kinetics limitations: Product chemistry under assay conditions; not a recommendation to raise chloride or thiocyanate intake. exposure: 100 mM chloride with varying thiocyanate evidence_span: {"source_cache": "artifacts/chloride-research/9359420.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "83dc6a264dfb45201104568ac58c76509aaa0fabca1f32efd25861146b4b38c0", "start_char": 0, "end_char": 1700, "text_sha256": "83dc6a264dfb45201104568ac58c76509aaa0fabca1f32efd25861146b4b38c0"} [chloride-p9359420] Thiocyanate and chloride as competing substrates for myeloperoxidase. (1997). https://pubmed.ncbi.nlm.nih.gov/9359420/ DOI: 10.1042/bj3270487
Complete structured claim and evidenceThe LPO/iodide/H2O2 system reduced RSV titre; the tested thiocyanate system did not inactivate RSV or adenovirus.
Experimental context and source evidence
- experimental_model
- Primary airway epithelial cultures and human oral-KI exposure; separate experimental arms.
- exposure_category
- Study-specific exposure, including pharmacological and in-vitro conditions; normal is the schema fallback outside the three availability categories.
- limitations
- Culture antiviral activity and human secretion measurements do not establish prevention or treatment of human infection.
- nutrient_topic
- Potassium iodide research collection; shared-anion and comparator studies are not all KI interventions. · Potassium iodide
- plain_language
- Iodide and thiocyanate were not interchangeable against these viruses.
- primary_references
- Enhancement of respiratory mucosal antiviral defenses by the oxidation of iodide. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21441383/ · DOI 10.1165/rcmb.2010-0329oc
Potassium iodide: thyroid and non-thyroid mechanisms, interactions and discovery questions (2026-09-18) · lines 80–86
AI-assisted research curation; primary-study references, chemical references and label statements individually identified. Not publisher full text. · supports · Primary airway epithelial cultures and human oral-KI exposure; separate experimental arms. · source_derived_draft · unverified_draft
## ki-air-rsv Iodide and thiocyanate were not interchangeable against these viruses. The LPO/iodide/H2O2 system reduced RSV titre; the tested thiocyanate system did not inactivate RSV or adenovirus. Model: Primary airway epithelial cultures and human oral-KI exposure; separate experimental arms. Limitations: Culture antiviral activity and human secretion measurements do not establish prevention or treatment of human infection. Evidence location: Primary abstract Enhancement of respiratory mucosal antiviral defenses by the oxidation of iodide. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21441383/ · DOI 10.1165/rcmb.2010-0329oc
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.