{"id":"cb2d6944-b859-59aa-a3fb-f0a459b160b3","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-saliva-null","predicate":"no_detected_change","statement":"Salivary thiocyanate and hypothiocyanite did not significantly change after contrast exposure.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"e5914264-0968-5fc3-bd3b-e2023f35e422","mechanism_event_label":"Not every component of the defence system increased.","subject":{"id":"46466f17-36bd-5b59-a646-a91814566209","slug":"iodinated-contrast-media","display_name":"Iodinated contrast media, study mixture","entity_type_key":"chemical_species"},"object":{"id":"3e27fd96-b277-54f3-bb7e-35b48f9622c6","slug":"hypothiocyanite","display_name":"Hypothiocyanite / OSCN−","entity_type_key":"chemical_species"},"evidence_count":1,"mechanism_event":{"id":"e5914264-0968-5fc3-bd3b-e2023f35e422","stable_key":"79018983-9179-5c1a-8e7a-d6f47a13582b:ki-saliva-null-event","event_type":"observed_relationship","label":"Not every component of the defence system increased.","description":"Salivary thiocyanate and hypothiocyanite did not significantly change after contrast exposure.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"46466f17-36bd-5b59-a646-a91814566209","slug":"iodinated-contrast-media","display_name":"Iodinated contrast media, study mixture","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3e27fd96-b277-54f3-bb7e-35b48f9622c6","slug":"hypothiocyanite","display_name":"Hypothiocyanite / OSCN−","entity_type_key":"chemical_species"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5d54e0a3-869f-5132-82c9-4c0ff47cd400","slug":"thiocyanate-ion","display_name":"Thiocyanate ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Paired saliva measurements in 40 coronary-angiography patients exposed to iodinated contrast.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure_category","value_text":"Study-specific exposure, including pharmacological and in-vitro conditions; normal is the schema fallback outside the three availability categories.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Contrast exposure is not oral KI; observational chemistry endpoints do not establish infection prevention or a safe effective supplement dose.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium iodide research collection; shared-anion and comparator studies are not all KI interventions.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium-iodide","display_name":"Potassium iodide","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Not every component of the defence system increased.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Excess iodine exposure acutely increases salivary iodide and antimicrobial hypoiodous acid concentrations in humans. · 2022 · https://pubmed.ncbi.nlm.nih.gov/36463312/ · DOI 10.1038/s41598-022-23803-8","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"2debbda2-6554-52da-8348-14297c9fd261","evidence_kind":"source_excerpt","locator":"Lines 176-182","start_line":176,"end_line":182,"excerpt":"## ki-saliva-null\nNot every component of the defence system increased.\nSalivary thiocyanate and hypothiocyanite did not significantly change after contrast exposure.\nModel: Paired saliva measurements in 40 coronary-angiography patients exposed to iodinated contrast.\nLimitations: Contrast exposure is not oral KI; observational chemistry endpoints do not establish infection prevention or a safe effective supplement dose.\nEvidence location: Primary abstract\nExcess iodine exposure acutely increases salivary iodide and antimicrobial hypoiodous acid concentrations in humans. · 2022 · https://pubmed.ncbi.nlm.nih.gov/36463312/ · DOI 10.1038/s41598-022-23803-8","model_system":"Paired saliva measurements in 40 coronary-angiography patients exposed to iodinated contrast.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Curation paraphrase; primary evidence location and source kind retained above.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc3ce411-f68f-5eb8-87c1-1592665f9cb6","stable_key":"import-79018983-9179-5c1a-8e7a-d6f47a13582b","title":"Potassium iodide: thyroid and non-thyroid mechanisms, interactions and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-study references, chemical references and label statements individually identified. 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