Component

Human erythrocyte ergothioneine concentration

Context-specific entity; species, compartment and exposure are stated on each claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Erythrocyte ergothioneine averaged 8% of control levels in hemodialysis participants and 24% in advanced CKD participants.

    Human hemodialysis → Human erythrocyte ergothioneine concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    evidence_access
    Primary abstract
    experimental_model
    Cross-group measurements plus clearance assessment.
    limitations
    Diet, disease and clearance may all contribute; no universal deficiency cutoff.
    nutrient_topic
    Ergothioneine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · L-Ergothioneine
    plain_language
    The blood-cell pool was substantially lower.
    primary_references
    Depletion by Hemodialysis of the Antioxidant Ergothioneine. · 2025 · https://pubmed.ncbi.nlm.nih.gov/39869777/ · DOI 10.34067/KID.0000000645
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Ergothioneine: transport, redox chemistry and cross-nutrient mechanisms (2026-09-19) · lines 536–542

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Cross-group measurements plus clearance assessment. · source_derived_draft · unverified_draft

    ## ergothioneine-hemodialysis-rbc The blood-cell pool was substantially lower. Erythrocyte ergothioneine averaged 8% of control levels in hemodialysis participants and 24% in advanced CKD participants. Model: Cross-group measurements plus clearance assessment. Limitations: Diet, disease and clearance may all contribute; no universal deficiency cutoff. Evidence access: Primary abstract Depletion by Hemodialysis of the Antioxidant Ergothioneine. · 2025 · https://pubmed.ncbi.nlm.nih.gov/39869777/ · DOI 10.34067/KID.0000000645
    Complete structured claim and evidence

  2. In a 10-man crossover study, mushroom meals containing 8 or 16 grams of mushroom powder produced postprandial erythrocyte ergothioneine uptake.

    Agaricus bisporus mushroom test meal → Human erythrocyte ergothioneine concentration source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Acute human mushroom-meal study.
    limitations
    Grams refer to mushroom powder, not pure ergothioneine; food-matrix effects cannot be assigned to this compound alone.
    nutrient_topic
    Ergothioneine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · L-Ergothioneine
    plain_language
    Food-derived ergothioneine reaches the blood-cell pool.
    primary_references
    The bioavailability of ergothioneine from mushrooms (Agaricus bisporus) and the acute effects on antioxidant capacity and biomarkers of inflammation. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22230474/ · DOI 10.1016/j.ypmed.2011.12.028

    Ergothioneine: transport, redox chemistry and cross-nutrient mechanisms (2026-09-19) · lines 456–462

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Acute human mushroom-meal study. · source_derived_draft · unverified_draft

    ## ergothioneine-mushroom-bioavailability Food-derived ergothioneine reaches the blood-cell pool. In a 10-man crossover study, mushroom meals containing 8 or 16 grams of mushroom powder produced postprandial erythrocyte ergothioneine uptake. Model: Acute human mushroom-meal study. Limitations: Grams refer to mushroom powder, not pure ergothioneine; food-matrix effects cannot be assigned to this compound alone. Evidence access: Primary abstract The bioavailability of ergothioneine from mushrooms (Agaricus bisporus) and the acute effects on antioxidant capacity and biomarkers of inflammation. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22230474/ · DOI 10.1016/j.ypmed.2011.12.028
    Complete structured claim and evidence

  3. In a later comparison, erythrocyte ergothioneine averaged 34% of control levels during peritoneal dialysis versus 10% during hemodialysis.

    Human peritoneal dialysis → Human erythrocyte ergothioneine concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    evidence_access
    Primary abstract
    experimental_model
    16 peritoneal dialysis, 16 hemodialysis and 15 controls.
    limitations
    Percentages belong to this cohort, not a contradiction of the earlier study; replacement benefits remain unknown.
    nutrient_topic
    Ergothioneine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · L-Ergothioneine
    plain_language
    Different dialysis routes were associated with different depletion.
    primary_references
    Ergothioneine Depletion in Peritoneal Dialysis. · 2026 · https://pubmed.ncbi.nlm.nih.gov/41411056/ · DOI 10.34067/KID.0000001105
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Ergothioneine: transport, redox chemistry and cross-nutrient mechanisms (2026-09-19) · lines 544–550

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · 16 peritoneal dialysis, 16 hemodialysis and 15 controls. · source_derived_draft · unverified_draft

    ## ergothioneine-peritoneal-rbc Different dialysis routes were associated with different depletion. In a later comparison, erythrocyte ergothioneine averaged 34% of control levels during peritoneal dialysis versus 10% during hemodialysis. Model: 16 peritoneal dialysis, 16 hemodialysis and 15 controls. Limitations: Percentages belong to this cohort, not a contradiction of the earlier study; replacement benefits remain unknown. Evidence access: Primary abstract Ergothioneine Depletion in Peritoneal Dialysis. · 2026 · https://pubmed.ncbi.nlm.nih.gov/41411056/ · DOI 10.34067/KID.0000001105
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards