{"id":"e1fb4557-d5b7-557e-ad18-126ac46a9abd","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-hemodialysis-rbc","predicate":"associated_with_lower","statement":"Erythrocyte ergothioneine averaged 8% of control levels in hemodialysis participants and 24% in advanced CKD participants.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"a20f110b-4560-57ff-99c3-975e1b6e9d5e","mechanism_event_label":"The blood-cell pool was substantially lower.","subject":{"id":"1040b68e-da1e-5408-8387-3a96b928d2df","slug":"human-hemodialysis","display_name":"Human hemodialysis","entity_type_key":"cellular_process"},"object":{"id":"6edb8cfd-7ddd-5cc6-8fb7-a9d4b22f8cad","slug":"human-erythrocyte-ergothioneine","display_name":"Human erythrocyte ergothioneine concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a20f110b-4560-57ff-99c3-975e1b6e9d5e","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-hemodialysis-rbc-event","event_type":"observed_relationship","label":"The blood-cell pool was substantially lower.","description":"Erythrocyte ergothioneine averaged 8% of control levels in hemodialysis participants and 24% in advanced CKD participants.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1040b68e-da1e-5408-8387-3a96b928d2df","slug":"human-hemodialysis","display_name":"Human hemodialysis","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6edb8cfd-7ddd-5cc6-8fb7-a9d4b22f8cad","slug":"human-erythrocyte-ergothioneine","display_name":"Human erythrocyte ergothioneine concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"939c92c3-50ea-5a4a-9654-8e3b94448132","slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Cross-group measurements plus clearance assessment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Diet, disease and clearance may all contribute; no universal deficiency cutoff.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Ergothioneine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The blood-cell pool was substantially lower.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Depletion by Hemodialysis of the Antioxidant Ergothioneine. · 2025 · https://pubmed.ncbi.nlm.nih.gov/39869777/ · DOI 10.34067/KID.0000000645","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"da75c0fb-f2d9-5510-b1e8-134d619cbc4d","evidence_kind":"source_excerpt","locator":"Lines 536-542","start_line":536,"end_line":542,"excerpt":"## ergothioneine-hemodialysis-rbc\nThe blood-cell pool was substantially lower.\nErythrocyte ergothioneine averaged 8% of control levels in hemodialysis participants and 24% in advanced CKD participants.\nModel: Cross-group measurements plus clearance assessment.\nLimitations: Diet, disease and clearance may all contribute; no universal deficiency cutoff.\nEvidence access: Primary abstract\nDepletion by Hemodialysis of the Antioxidant Ergothioneine. · 2025 · https://pubmed.ncbi.nlm.nih.gov/39869777/ · DOI 10.34067/KID.0000000645","model_system":"Cross-group measurements plus clearance assessment.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2f037d98-f3d0-5dbe-80d8-90b738f130d6","stable_key":"import-59b18080-c560-563d-abc5-bac4ee82a27c","title":"Ergothioneine: transport, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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