{"id":"4fa5a7e1-759a-5a43-af3d-a365e5bb5e57","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-mushroom-bioavailability","predicate":"increases","statement":"In a 10-man crossover study, mushroom meals containing 8 or 16 grams of mushroom powder produced postprandial erythrocyte ergothioneine uptake.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"20c504b5-d867-5cc3-bae6-d6e986008d1f","mechanism_event_label":"Food-derived ergothioneine reaches the blood-cell pool.","subject":{"id":"15ad9eb9-fba4-5e2f-a3ae-c9637a9c558b","slug":"agaricus-bisporus-meal","display_name":"Agaricus bisporus mushroom test meal","entity_type_key":"cellular_process"},"object":{"id":"6edb8cfd-7ddd-5cc6-8fb7-a9d4b22f8cad","slug":"human-erythrocyte-ergothioneine","display_name":"Human erythrocyte ergothioneine concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"20c504b5-d867-5cc3-bae6-d6e986008d1f","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-mushroom-bioavailability-event","event_type":"observed_relationship","label":"Food-derived ergothioneine reaches the blood-cell pool.","description":"In a 10-man crossover study, mushroom meals containing 8 or 16 grams of mushroom powder produced postprandial erythrocyte ergothioneine uptake.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"15ad9eb9-fba4-5e2f-a3ae-c9637a9c558b","slug":"agaricus-bisporus-meal","display_name":"Agaricus bisporus mushroom test meal","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6edb8cfd-7ddd-5cc6-8fb7-a9d4b22f8cad","slug":"human-erythrocyte-ergothioneine","display_name":"Human erythrocyte ergothioneine concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"939c92c3-50ea-5a4a-9654-8e3b94448132","slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Acute human mushroom-meal study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Grams refer to mushroom powder, not pure ergothioneine; food-matrix effects cannot be assigned to this compound alone.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Ergothioneine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Food-derived ergothioneine reaches the blood-cell pool.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The bioavailability of ergothioneine from mushrooms (Agaricus bisporus) and the acute effects on antioxidant capacity and biomarkers of inflammation. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22230474/ · DOI 10.1016/j.ypmed.2011.12.028","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"999fb0da-cf94-5520-8507-cbe24389ee11","evidence_kind":"source_excerpt","locator":"Lines 456-462","start_line":456,"end_line":462,"excerpt":"## ergothioneine-mushroom-bioavailability\nFood-derived ergothioneine reaches the blood-cell pool.\nIn a 10-man crossover study, mushroom meals containing 8 or 16 grams of mushroom powder produced postprandial erythrocyte ergothioneine uptake.\nModel: Acute human mushroom-meal study.\nLimitations: Grams refer to mushroom powder, not pure ergothioneine; food-matrix effects cannot be assigned to this compound alone.\nEvidence access: Primary abstract\nThe bioavailability of ergothioneine from mushrooms (Agaricus bisporus) and the acute effects on antioxidant capacity and biomarkers of inflammation. · 2012 · https://pubmed.ncbi.nlm.nih.gov/22230474/ · DOI 10.1016/j.ypmed.2011.12.028","model_system":"Acute human mushroom-meal study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2f037d98-f3d0-5dbe-80d8-90b738f130d6","stable_key":"import-59b18080-c560-563d-abc5-bac4ee82a27c","title":"Ergothioneine: transport, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b6def8119f03cfabeec2fb55ba924340dc612e1dd42f05404201fa2b7ced5259","revision_id":"f88c38e6-ffb5-5a68-83ca-4610ca2c2df4","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}