{"id":"817d469a-94bc-57fb-9a57-8fd4bdf0275f","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-peritoneal-rbc","predicate":"associated_with_lower","statement":"In a later comparison, erythrocyte ergothioneine averaged 34% of control levels during peritoneal dialysis versus 10% during hemodialysis.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"3b65ff7a-cf7b-55b0-a58a-7eade47ef9ba","mechanism_event_label":"Different dialysis routes were associated with different depletion.","subject":{"id":"9091bc50-946d-5331-8df7-6412c6ec17ee","slug":"human-peritoneal-dialysis","display_name":"Human peritoneal dialysis","entity_type_key":"cellular_process"},"object":{"id":"6edb8cfd-7ddd-5cc6-8fb7-a9d4b22f8cad","slug":"human-erythrocyte-ergothioneine","display_name":"Human erythrocyte ergothioneine concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3b65ff7a-cf7b-55b0-a58a-7eade47ef9ba","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-peritoneal-rbc-event","event_type":"observed_relationship","label":"Different dialysis routes were associated with different depletion.","description":"In a later comparison, erythrocyte ergothioneine averaged 34% of control levels during peritoneal dialysis versus 10% during hemodialysis.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9091bc50-946d-5331-8df7-6412c6ec17ee","slug":"human-peritoneal-dialysis","display_name":"Human peritoneal dialysis","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6edb8cfd-7ddd-5cc6-8fb7-a9d4b22f8cad","slug":"human-erythrocyte-ergothioneine","display_name":"Human erythrocyte ergothioneine concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"939c92c3-50ea-5a4a-9654-8e3b94448132","slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"16 peritoneal dialysis, 16 hemodialysis and 15 controls.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Percentages belong to this cohort, not a contradiction of the earlier study; replacement benefits remain unknown.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Ergothioneine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Different dialysis routes were associated with different depletion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Ergothioneine Depletion in Peritoneal Dialysis. · 2026 · https://pubmed.ncbi.nlm.nih.gov/41411056/ · DOI 10.34067/KID.0000001105","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; 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