Component
Human hemodialysis
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
Hemodialysis cleared ergothioneine at 146 +/- 36 mL/min in the measured cohort, exceeding urinary removal in controls and CKD participants.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- evidence_access
- Primary abstract
- experimental_model
- 11 hemodialysis, 12 advanced CKD and 12 control participants.
- limitations
- Removal measured; clinical benefit from replacing the solute remains untested.
- nutrient_topic
- Ergothioneine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · L-Ergothioneine
- plain_language
- Dialysis can bypass the kidney retention mechanism.
- primary_references
- Depletion by Hemodialysis of the Antioxidant Ergothioneine. · 2025 · https://pubmed.ncbi.nlm.nih.gov/39869777/ · DOI 10.34067/KID.0000000645
- trigger_kind
- biomarker_context Imported condition classification; unverified.
Ergothioneine: transport, redox chemistry and cross-nutrient mechanisms (2026-09-19) · lines 528–534
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · 11 hemodialysis, 12 advanced CKD and 12 control participants. · source_derived_draft · unverified_draft
## ergothioneine-hemodialysis-clearance Dialysis can bypass the kidney retention mechanism. Hemodialysis cleared ergothioneine at 146 +/- 36 mL/min in the measured cohort, exceeding urinary removal in controls and CKD participants. Model: 11 hemodialysis, 12 advanced CKD and 12 control participants. Limitations: Removal measured; clinical benefit from replacing the solute remains untested. Evidence access: Primary abstract Depletion by Hemodialysis of the Antioxidant Ergothioneine. · 2025 · https://pubmed.ncbi.nlm.nih.gov/39869777/ · DOI 10.34067/KID.0000000645
Complete structured claim and evidenceErythrocyte ergothioneine averaged 8% of control levels in hemodialysis participants and 24% in advanced CKD participants.
Experimental context and source evidence
- availability_state
- biomarker_context Imported condition classification; unverified.
- evidence_access
- Primary abstract
- experimental_model
- Cross-group measurements plus clearance assessment.
- limitations
- Diet, disease and clearance may all contribute; no universal deficiency cutoff.
- nutrient_topic
- Ergothioneine collection; molecular form, preparation, species, exposure and manipulation remain explicit. · L-Ergothioneine
- plain_language
- The blood-cell pool was substantially lower.
- primary_references
- Depletion by Hemodialysis of the Antioxidant Ergothioneine. · 2025 · https://pubmed.ncbi.nlm.nih.gov/39869777/ · DOI 10.34067/KID.0000000645
- trigger_kind
- biomarker_context Imported condition classification; unverified.
Ergothioneine: transport, redox chemistry and cross-nutrient mechanisms (2026-09-19) · lines 536–542
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Cross-group measurements plus clearance assessment. · source_derived_draft · unverified_draft
## ergothioneine-hemodialysis-rbc The blood-cell pool was substantially lower. Erythrocyte ergothioneine averaged 8% of control levels in hemodialysis participants and 24% in advanced CKD participants. Model: Cross-group measurements plus clearance assessment. Limitations: Diet, disease and clearance may all contribute; no universal deficiency cutoff. Evidence access: Primary abstract Depletion by Hemodialysis of the Antioxidant Ergothioneine. · 2025 · https://pubmed.ncbi.nlm.nih.gov/39869777/ · DOI 10.34067/KID.0000000645
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.