{"id":"695ea611-9f60-50ef-b685-a09aad348dac","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-hemodialysis-clearance","predicate":"removes","statement":"Hemodialysis cleared ergothioneine at 146 +/- 36 mL/min in the measured cohort, exceeding urinary removal in controls and CKD participants.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"02c2c88e-b122-5c6d-b8fe-7aa6951dbb1d","mechanism_event_label":"Dialysis can bypass the kidney retention mechanism.","subject":{"id":"1040b68e-da1e-5408-8387-3a96b928d2df","slug":"human-hemodialysis","display_name":"Human hemodialysis","entity_type_key":"cellular_process"},"object":{"id":"939c92c3-50ea-5a4a-9654-8e3b94448132","slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"02c2c88e-b122-5c6d-b8fe-7aa6951dbb1d","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-hemodialysis-clearance-event","event_type":"observed_relationship","label":"Dialysis can bypass the kidney retention mechanism.","description":"Hemodialysis cleared ergothioneine at 146 +/- 36 mL/min in the measured cohort, exceeding urinary removal in controls and CKD participants.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1040b68e-da1e-5408-8387-3a96b928d2df","slug":"human-hemodialysis","display_name":"Human hemodialysis","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"939c92c3-50ea-5a4a-9654-8e3b94448132","slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"11 hemodialysis, 12 advanced CKD and 12 control participants.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Removal measured; clinical benefit from replacing the solute remains untested.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Ergothioneine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Dialysis can bypass the kidney retention mechanism.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Depletion by Hemodialysis of the Antioxidant Ergothioneine. · 2025 · https://pubmed.ncbi.nlm.nih.gov/39869777/ · DOI 10.34067/KID.0000000645","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"b37d2919-390b-5db7-af91-98f3ab99e2f1","evidence_kind":"source_excerpt","locator":"Lines 528-534","start_line":528,"end_line":534,"excerpt":"## ergothioneine-hemodialysis-clearance\nDialysis can bypass the kidney retention mechanism.\nHemodialysis cleared ergothioneine at 146 +/- 36 mL/min in the measured cohort, exceeding urinary removal in controls and CKD participants.\nModel: 11 hemodialysis, 12 advanced CKD and 12 control participants.\nLimitations: Removal measured; clinical benefit from replacing the solute remains untested.\nEvidence access: Primary abstract\nDepletion by Hemodialysis of the Antioxidant Ergothioneine. · 2025 · https://pubmed.ncbi.nlm.nih.gov/39869777/ · DOI 10.34067/KID.0000000645","model_system":"11 hemodialysis, 12 advanced CKD and 12 control participants.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2f037d98-f3d0-5dbe-80d8-90b738f130d6","stable_key":"import-59b18080-c560-563d-abc5-bac4ee82a27c","title":"Ergothioneine: transport, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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