Component

GW9662

GW9662. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. GW9662 reversed the anti-inflammatory effect of mangiferin in the chondrocyte study.

    GW9662 → Inflammatory response in human osteoarthritis chondrocytes source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/mangiferin-research/27734234.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1b9924d15171028fb1006c5e72c7b0dc6742d96f6873a292e6f5741061ad2f44", "start_char": 0, "end_char": 1007, "text_sha256": "1b9924d15171028fb1006c5e72c7b0dc6742d96f6873a292e6f5741061ad2f44"}
    experimental_model
    IL-1beta-stimulated osteoarthritis chondrocytes with inhibitor perturbation
    exposure
    Mangiferin with IL-1beta; PPAR-gamma inhibitor GW9662
    limitations
    The indexed abstract reports reversal of anti-inflammatory effects collectively; endpoint-specific magnitude is unresolved.
    nutrient_topic
    Mangiferin research collection; topical membership is not evidence of a direct dietary effect. · Mangiferin
    organism
    Homo sapiens
    plain_language
    Blocking related machinery weakened the response.
    primary_references
    [mangiferin-p27734234] Mangiferin Inhibits IL-1β-Induced Inflammatory Response by Activating PPAR-γ in Human Osteoarthritis Chondrocytes. (2017). https://pubmed.ncbi.nlm.nih.gov/27734234/ DOI: 10.1007/s10753-016-0451-y
    tissue_or_cell_type
    Cultured chondrocytes
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Mangiferin: metabolism, signaling and nutrient connections (2026-09-17) · lines 1342–1353

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · IL-1beta-stimulated osteoarthritis chondrocytes with inhibitor perturbation · source_derived_draft · unverified_draft

    ### mangiferin-pparg-loss GW9662 reversed the anti-inflammatory effect of mangiferin in the chondrocyte study. Condition category: machinery_impairment nutrient_topic: Mangiferin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Blocking related machinery weakened the response. organism: Homo sapiens tissue_or_cell_type: Cultured chondrocytes experimental_model: IL-1beta-stimulated osteoarthritis chondrocytes with inhibitor perturbation limitations: The indexed abstract reports reversal of anti-inflammatory effects collectively; endpoint-specific magnitude is unresolved. exposure: Mangiferin with IL-1beta; PPAR-gamma inhibitor GW9662 evidence_span: {"source_cache": "artifacts/mangiferin-research/27734234.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1b9924d15171028fb1006c5e72c7b0dc6742d96f6873a292e6f5741061ad2f44", "start_char": 0, "end_char": 1007, "text_sha256": "1b9924d15171028fb1006c5e72c7b0dc6742d96f6873a292e6f5741061ad2f44"} [mangiferin-p27734234] Mangiferin Inhibits IL-1β-Induced Inflammatory Response by Activating PPAR-γ in Human Osteoarthritis Chondrocytes. (2017). https://pubmed.ncbi.nlm.nih.gov/27734234/ DOI: 10.1007/s10753-016-0451-y
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. GW9662 antagonism abolished tested insulin-sensitivity effects of ankaflavin in methylglyoxal-treated Wistar rats.

    Rat peroxisome proliferator-activated receptor gamma / Pparg → Rat insulin-response endpoints during ankaflavin treatment source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary abstract
    experimental_model
    Four-week rat model; methylglyoxal 600 mg/kg and ankaflavin 10 mg/kg as reported.
    limitations
    Drug-induced rodent model; not an established treatment for human diabetes.
    nutrient_topic
    Red yeast rice collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Red yeast rice
    plain_language
    Blocking the receptor helped test pathway involvement.
    primary_references
    [23022408] Ankaflavin: a natural novel PPARγ agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo. · 2012 · https://pubmed.ncbi.nlm.nih.gov/23022408/ · DOI 10.1016/j.freeradbiomed.2012.09.025
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Red yeast rice: constituents, mevalonate, CoQ and product-specific interactions (2026-09-20) · lines 236–242

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Four-week rat model; methylglyoxal 600 mg/kg and ankaflavin 10 mg/kg as reported. · source_derived_draft · unverified_draft

    ## red-yeast-rice-ankaflavin-pparg-blockade Blocking the receptor helped test pathway involvement. GW9662 antagonism abolished tested insulin-sensitivity effects of ankaflavin in methylglyoxal-treated Wistar rats. Model: Four-week rat model; methylglyoxal 600 mg/kg and ankaflavin 10 mg/kg as reported. Limitations: Drug-induced rodent model; not an established treatment for human diabetes. Evidence access: Primary abstract [23022408] Ankaflavin: a natural novel PPARγ agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo. · 2012 · https://pubmed.ncbi.nlm.nih.gov/23022408/ · DOI 10.1016/j.freeradbiomed.2012.09.025
    Complete structured claim and evidence

  2. CLA increased TFF3 in human SW480 cells; PPAR-gamma antagonist GW9662 prevented this induction.

    Study-specific mixed-isomer CLA preparations → Human trefoil factor 3 / TFF3 source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human colorectal cell line, 0–2.5 micromolar CLA.
    limitations
    Pharmacological support does not identify the active isomer or prove human mucosal healing.
    nutrient_topic
    CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
    plain_language
    A mucosal-repair protein responded through a receptor-sensitive pathway.
    primary_references
    Dietary conjugated linoleic acid activates PPARγ and the intestinal trefoil factor in SW480 cells and mice with dextran sulfate sodium-induced colitis. · 2012 · https://pubmed.ncbi.nlm.nih.gov/23077197/ · DOI 10.3945/jn.112.163931

    Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 374–380

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Human colorectal cell line, 0–2.5 micromolar CLA. · source_derived_draft · unverified_draft

    ## cla-tff3 A mucosal-repair protein responded through a receptor-sensitive pathway. CLA increased TFF3 in human SW480 cells; PPAR-gamma antagonist GW9662 prevented this induction. Model: Human colorectal cell line, 0–2.5 micromolar CLA. Limitations: Pharmacological support does not identify the active isomer or prove human mucosal healing. Evidence access: Primary abstract Dietary conjugated linoleic acid activates PPARγ and the intestinal trefoil factor in SW480 cells and mice with dextran sulfate sodium-induced colitis. · 2012 · https://pubmed.ncbi.nlm.nih.gov/23077197/ · DOI 10.3945/jn.112.163931
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards