Component
Human trefoil factor 3 / TFF3
Context-specific entity; species, compartment and exposure are stated on each claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
CLA increased TFF3 in human SW480 cells; PPAR-gamma antagonist GW9662 prevented this induction.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Human colorectal cell line, 0–2.5 micromolar CLA.
- limitations
- Pharmacological support does not identify the active isomer or prove human mucosal healing.
- nutrient_topic
- CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
- plain_language
- A mucosal-repair protein responded through a receptor-sensitive pathway.
- primary_references
- Dietary conjugated linoleic acid activates PPARγ and the intestinal trefoil factor in SW480 cells and mice with dextran sulfate sodium-induced colitis. · 2012 · https://pubmed.ncbi.nlm.nih.gov/23077197/ · DOI 10.3945/jn.112.163931
Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 374–380
AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Human colorectal cell line, 0–2.5 micromolar CLA. · source_derived_draft · unverified_draft
## cla-tff3 A mucosal-repair protein responded through a receptor-sensitive pathway. CLA increased TFF3 in human SW480 cells; PPAR-gamma antagonist GW9662 prevented this induction. Model: Human colorectal cell line, 0–2.5 micromolar CLA. Limitations: Pharmacological support does not identify the active isomer or prove human mucosal healing. Evidence access: Primary abstract Dietary conjugated linoleic acid activates PPARγ and the intestinal trefoil factor in SW480 cells and mice with dextran sulfate sodium-induced colitis. · 2012 · https://pubmed.ncbi.nlm.nih.gov/23077197/ · DOI 10.3945/jn.112.163931
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.