Component
Inflammatory response in human osteoarthritis chondrocytes
Inflammatory response in human osteoarthritis chondrocytes. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
GW9662 reversed the anti-inflammatory effect of mangiferin in the chondrocyte study.
Experimental context and source evidence
- availability_state
- machinery_impairment Imported condition classification; unverified.
- evidence_span
- {"source_cache": "artifacts/mangiferin-research/27734234.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1b9924d15171028fb1006c5e72c7b0dc6742d96f6873a292e6f5741061ad2f44", "start_char": 0, "end_char": 1007, "text_sha256": "1b9924d15171028fb1006c5e72c7b0dc6742d96f6873a292e6f5741061ad2f44"}
- experimental_model
- IL-1beta-stimulated osteoarthritis chondrocytes with inhibitor perturbation
- exposure
- Mangiferin with IL-1beta; PPAR-gamma inhibitor GW9662
- limitations
- The indexed abstract reports reversal of anti-inflammatory effects collectively; endpoint-specific magnitude is unresolved.
- nutrient_topic
- Mangiferin research collection; topical membership is not evidence of a direct dietary effect. · Mangiferin
- organism
- Homo sapiens
- plain_language
- Blocking related machinery weakened the response.
- primary_references
- [mangiferin-p27734234] Mangiferin Inhibits IL-1β-Induced Inflammatory Response by Activating PPAR-γ in Human Osteoarthritis Chondrocytes. (2017). https://pubmed.ncbi.nlm.nih.gov/27734234/ DOI: 10.1007/s10753-016-0451-y
- tissue_or_cell_type
- Cultured chondrocytes
- trigger_kind
- machinery_impairment Imported condition classification; unverified.
Mangiferin: metabolism, signaling and nutrient connections (2026-09-17) · lines 1342–1353
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · IL-1beta-stimulated osteoarthritis chondrocytes with inhibitor perturbation · source_derived_draft · unverified_draft
### mangiferin-pparg-loss GW9662 reversed the anti-inflammatory effect of mangiferin in the chondrocyte study. Condition category: machinery_impairment nutrient_topic: Mangiferin research collection; topical membership is not evidence of a direct dietary effect. plain_language: Blocking related machinery weakened the response. organism: Homo sapiens tissue_or_cell_type: Cultured chondrocytes experimental_model: IL-1beta-stimulated osteoarthritis chondrocytes with inhibitor perturbation limitations: The indexed abstract reports reversal of anti-inflammatory effects collectively; endpoint-specific magnitude is unresolved. exposure: Mangiferin with IL-1beta; PPAR-gamma inhibitor GW9662 evidence_span: {"source_cache": "artifacts/mangiferin-research/27734234.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1b9924d15171028fb1006c5e72c7b0dc6742d96f6873a292e6f5741061ad2f44", "start_char": 0, "end_char": 1007, "text_sha256": "1b9924d15171028fb1006c5e72c7b0dc6742d96f6873a292e6f5741061ad2f44"} [mangiferin-p27734234] Mangiferin Inhibits IL-1β-Induced Inflammatory Response by Activating PPAR-γ in Human Osteoarthritis Chondrocytes. (2017). https://pubmed.ncbi.nlm.nih.gov/27734234/ DOI: 10.1007/s10753-016-0451-y
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.