{"id":"aee9b604-61ec-58e7-a763-c78f8a4316bb","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-ankaflavin-pparg-blockade","predicate":"when_antagonized_attenuates","statement":"GW9662 antagonism abolished tested insulin-sensitivity effects of ankaflavin in methylglyoxal-treated Wistar rats.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"fae22f32-4be5-5db3-ba62-1a8b26e997fd","mechanism_event_label":"Blocking the receptor helped test pathway involvement.","subject":{"id":"9b53298b-4b3d-5a7e-98cb-139f5d617130","slug":"rat-pparg","display_name":"Rat peroxisome proliferator-activated receptor gamma / Pparg","entity_type_key":"protein"},"object":{"id":"a3c18114-70ee-5722-ae69-96d79f60806d","slug":"rat-ankaflavin-insulin-response","display_name":"Rat insulin-response endpoints during ankaflavin treatment","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"fae22f32-4be5-5db3-ba62-1a8b26e997fd","stable_key":"4910e17b-aaec-52cd-b9e5-caca85d817ee:red-yeast-rice-ankaflavin-pparg-blockade-event","event_type":"observed_relationship","label":"Blocking the receptor helped test pathway involvement.","description":"GW9662 antagonism abolished tested insulin-sensitivity effects of ankaflavin in methylglyoxal-treated Wistar rats.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9b53298b-4b3d-5a7e-98cb-139f5d617130","slug":"rat-pparg","display_name":"Rat peroxisome proliferator-activated receptor gamma / Pparg","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a3c18114-70ee-5722-ae69-96d79f60806d","slug":"rat-ankaflavin-insulin-response","display_name":"Rat insulin-response endpoints during ankaflavin treatment","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"92939faa-84d1-52e8-a70f-deefd2486d52","slug":"ankaflavin","display_name":"Ankaflavin","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"a8efc31d-682c-5f0b-b02c-acbdf7560139","slug":"gw9662","display_name":"GW9662","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"55c17a25-868a-5496-a200-88d9ec014558","slug":"methylglyoxal","display_name":"Methylglyoxal","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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