Component

5-HT3-agonist-induced contraction of guinea-pig ileum

Experimental species, exposure and limitations are retained on each claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. 10-Gingerol reduced contractions elicited by the selective 5-HT3 agonist in isolated guinea-pig ileum.

    10-Gingerol → 5-HT3-agonist-induced contraction of guinea-pig ileum source_derived_draftungraded
    Experimental context and source evidence
    dose
    Gingerols with selective 5-HT3 agonist SR57227A; exact range not in accessed abstract
    duration
    Not specified in accessed abstract
    evidence_access
    Primary PubMed abstract.
    evidence_scope
    literature_reviewed; model-specific source-derived curation, not universally established human effects
    experimental_model
    Isolated guinea-pig ileum
    limitations
    Muscarinic and substance-P-dependent downstream effects may contribute; no human antiemetic efficacy is measured.
    nutrient_topic
    Gingerols collection; each molecular form and experimental preparation remains explicit. · Gingerols
    organism
    Isolated guinea-pig ileum
    plain_language
    10-Gingerol reduced contractions elicited by the selective 5-HT3 agonist in isolated guinea-pig ileum.
    primary_references
    Mode of action of gingerols and shogaols on 5-HT3 receptors: binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum. (2006). https://pubmed.ncbi.nlm.nih.gov/16364290/ DOI: 10.1016/j.ejphar.2005.10.049
    route
    Ex vivo addition
    tissue
    Intestinal smooth muscle preparation

    Gingerols: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 140–149

    Original AI-assisted curation of thirteen primary research papers; study-specific PubMed/DOI links and limitations retained. Not publisher full text. · supports · Isolated guinea-pig ileum · source_derived_draft · unverified_draft

    ## gingerols-10-ileum 10-Gingerol reduced contractions elicited by the selective 5-HT3 agonist in isolated guinea-pig ileum. Model/species: Isolated guinea-pig ileum Tissue: Intestinal smooth muscle preparation Exposure: Gingerols with selective 5-HT3 agonist SR57227A; exact range not in accessed abstract Route: Ex vivo addition Duration: Not specified in accessed abstract Limits: Muscarinic and substance-P-dependent downstream effects may contribute; no human antiemetic efficacy is measured. Primary reference: Mode of action of gingerols and shogaols on 5-HT3 receptors: binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum. (2006). https://pubmed.ncbi.nlm.nih.gov/16364290/ DOI: 10.1016/j.ejphar.2005.10.049 Access: Primary PubMed abstract.
    Complete structured claim and evidence

  2. 6-Gingerol reduced contractions elicited by the selective 5-HT3 agonist in isolated guinea-pig ileum.

    6-Gingerol → 5-HT3-agonist-induced contraction of guinea-pig ileum source_derived_draftungraded
    Experimental context and source evidence
    dose
    Gingerols with selective 5-HT3 agonist SR57227A; exact range not in accessed abstract
    duration
    Not specified in accessed abstract
    evidence_access
    Primary PubMed abstract.
    evidence_scope
    literature_reviewed; model-specific source-derived curation, not universally established human effects
    experimental_model
    Isolated guinea-pig ileum
    limitations
    Muscarinic and substance-P-dependent downstream effects may contribute; no human antiemetic efficacy is measured.
    nutrient_topic
    Gingerols collection; each molecular form and experimental preparation remains explicit. · Gingerols
    organism
    Isolated guinea-pig ileum
    plain_language
    6-Gingerol reduced contractions elicited by the selective 5-HT3 agonist in isolated guinea-pig ileum.
    primary_references
    Mode of action of gingerols and shogaols on 5-HT3 receptors: binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum. (2006). https://pubmed.ncbi.nlm.nih.gov/16364290/ DOI: 10.1016/j.ejphar.2005.10.049
    route
    Ex vivo addition
    tissue
    Intestinal smooth muscle preparation

    Gingerols: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 74–83

    Original AI-assisted curation of thirteen primary research papers; study-specific PubMed/DOI links and limitations retained. Not publisher full text. · supports · Isolated guinea-pig ileum · source_derived_draft · unverified_draft

    ## gingerols-6-ileum 6-Gingerol reduced contractions elicited by the selective 5-HT3 agonist in isolated guinea-pig ileum. Model/species: Isolated guinea-pig ileum Tissue: Intestinal smooth muscle preparation Exposure: Gingerols with selective 5-HT3 agonist SR57227A; exact range not in accessed abstract Route: Ex vivo addition Duration: Not specified in accessed abstract Limits: Muscarinic and substance-P-dependent downstream effects may contribute; no human antiemetic efficacy is measured. Primary reference: Mode of action of gingerols and shogaols on 5-HT3 receptors: binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum. (2006). https://pubmed.ncbi.nlm.nih.gov/16364290/ DOI: 10.1016/j.ejphar.2005.10.049 Access: Primary PubMed abstract.
    Complete structured claim and evidence

  3. 8-Gingerol reduced contractions elicited by the selective 5-HT3 agonist in isolated guinea-pig ileum.

    8-Gingerol → 5-HT3-agonist-induced contraction of guinea-pig ileum source_derived_draftungraded
    Experimental context and source evidence
    dose
    Gingerols with selective 5-HT3 agonist SR57227A; exact range not in accessed abstract
    duration
    Not specified in accessed abstract
    evidence_access
    Primary PubMed abstract.
    evidence_scope
    literature_reviewed; model-specific source-derived curation, not universally established human effects
    experimental_model
    Isolated guinea-pig ileum
    limitations
    Muscarinic and substance-P-dependent downstream effects may contribute; no human antiemetic efficacy is measured.
    nutrient_topic
    Gingerols collection; each molecular form and experimental preparation remains explicit. · Gingerols
    organism
    Isolated guinea-pig ileum
    plain_language
    8-Gingerol reduced contractions elicited by the selective 5-HT3 agonist in isolated guinea-pig ileum.
    primary_references
    Mode of action of gingerols and shogaols on 5-HT3 receptors: binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum. (2006). https://pubmed.ncbi.nlm.nih.gov/16364290/ DOI: 10.1016/j.ejphar.2005.10.049
    route
    Ex vivo addition
    tissue
    Intestinal smooth muscle preparation

    Gingerols: mechanisms, molecular forms and cross-actor connections (2026-09-20) · lines 107–116

    Original AI-assisted curation of thirteen primary research papers; study-specific PubMed/DOI links and limitations retained. Not publisher full text. · supports · Isolated guinea-pig ileum · source_derived_draft · unverified_draft

    ## gingerols-8-ileum 8-Gingerol reduced contractions elicited by the selective 5-HT3 agonist in isolated guinea-pig ileum. Model/species: Isolated guinea-pig ileum Tissue: Intestinal smooth muscle preparation Exposure: Gingerols with selective 5-HT3 agonist SR57227A; exact range not in accessed abstract Route: Ex vivo addition Duration: Not specified in accessed abstract Limits: Muscarinic and substance-P-dependent downstream effects may contribute; no human antiemetic efficacy is measured. Primary reference: Mode of action of gingerols and shogaols on 5-HT3 receptors: binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum. (2006). https://pubmed.ncbi.nlm.nih.gov/16364290/ DOI: 10.1016/j.ejphar.2005.10.049 Access: Primary PubMed abstract.
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards