{"id":"6675bf49-c2c6-5839-a4df-0687cfb3a9d9","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-8-ileum","predicate":"inhibits","statement":"8-Gingerol reduced contractions elicited by the selective 5-HT3 agonist in isolated guinea-pig ileum.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"217a86ab-cc34-5034-af30-ded9a1ecba7b","mechanism_event_label":"8-Gingerol reduced contractions elicited by the selective 5-HT3 agonist in isolated guinea-pig ileum.","subject":{"id":"d15f1089-e355-5f5e-8c76-5021ade1dc75","slug":"8-gingerol","display_name":"8-Gingerol","entity_type_key":"small_molecule"},"object":{"id":"1f27ac50-6608-5b4c-ad5b-a92d6652c49e","slug":"guinea-pig-5ht3-ileal-contraction","display_name":"5-HT3-agonist-induced contraction of guinea-pig ileum","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"217a86ab-cc34-5034-af30-ded9a1ecba7b","stable_key":"fd7915ff-856d-56c2-a118-4989693a7644:gingerols-8-ileum-event","event_type":"observed_relationship","label":"8-Gingerol reduced contractions elicited by the selective 5-HT3 agonist in isolated guinea-pig ileum.","description":"8-Gingerol reduced contractions elicited by the selective 5-HT3 agonist in isolated guinea-pig ileum.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d15f1089-e355-5f5e-8c76-5021ade1dc75","slug":"8-gingerol","display_name":"8-Gingerol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"1f27ac50-6608-5b4c-ad5b-a92d6652c49e","slug":"guinea-pig-5ht3-ileal-contraction","display_name":"5-HT3-agonist-induced contraction of guinea-pig ileum","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Gingerols with selective 5-HT3 agonist SR57227A; exact range not in accessed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Not specified in accessed abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation, not universally established human effects","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Isolated guinea-pig ileum","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Muscarinic and substance-P-dependent downstream effects may contribute; no human antiemetic efficacy is measured.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Gingerols collection; each molecular form and experimental preparation remains explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"gingerols","display_name":"Gingerols","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Isolated guinea-pig ileum","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"8-Gingerol reduced contractions elicited by the selective 5-HT3 agonist in isolated guinea-pig ileum.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Mode of action of gingerols and shogaols on 5-HT3 receptors: binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum. (2006). https://pubmed.ncbi.nlm.nih.gov/16364290/ DOI: 10.1016/j.ejphar.2005.10.049","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Ex vivo addition","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Intestinal smooth muscle preparation","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"cc7c2c23-9f3f-58b4-8de7-9ce7b105d8bc","evidence_kind":"source_excerpt","locator":"Lines 107-116","start_line":107,"end_line":116,"excerpt":"## gingerols-8-ileum\n8-Gingerol reduced contractions elicited by the selective 5-HT3 agonist in isolated guinea-pig ileum.\nModel/species: Isolated guinea-pig ileum\nTissue: Intestinal smooth muscle preparation\nExposure: Gingerols with selective 5-HT3 agonist SR57227A; exact range not in accessed abstract\nRoute: Ex vivo addition\nDuration: Not specified in accessed abstract\nLimits: Muscarinic and substance-P-dependent downstream effects may contribute; no human antiemetic efficacy is measured.\nPrimary reference: Mode of action of gingerols and shogaols on 5-HT3 receptors: binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum. (2006). https://pubmed.ncbi.nlm.nih.gov/16364290/ DOI: 10.1016/j.ejphar.2005.10.049\nAccess: Primary PubMed abstract.","model_system":"Isolated guinea-pig ileum","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact archived synthesis span with its primary citation; original paraphrase, not a claimed publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"1107d60b-8e2d-55d7-8f5d-5612c49aa7dc","stable_key":"import-fd7915ff-856d-56c2-a118-4989693a7644","title":"Gingerols: mechanisms, molecular forms and cross-actor connections (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of thirteen primary research papers; study-specific PubMed/DOI links and limitations retained. 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