Component

Human growth hormone

Study-scoped entity; inspect species, exposure and experimental limitations on each claim.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Growth-hormone levels increased after 72 hours of fasting.

    Fasting / abstention from energy intake → Human growth hormone source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Nine obese men; randomized crossover with overnight fast, 72-hour fast, and fast plus GH blockade.
    limitations
    Hormone concentration is not a direct measure of anabolic flux.
    nutrient_topic
    Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished. · Fasting / abstention from energy intake
    plain_language
    Fasting changed hormone signaling without proving muscle growth.
    primary_references
    Substrate Metabolism and Insulin Sensitivity During Fasting in Obese Human Subjects: Impact of GH Blockade. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28324055/ · DOI 10.1210/jc.2016-3835

    Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18) · lines 208–214

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Nine obese men; randomized crossover with overnight fast, 72-hour fast, and fast plus GH blockade. · source_derived_draft · unverified_draft

    ## fast-gh-rise Fasting changed hormone signaling without proving muscle growth. Growth-hormone levels increased after 72 hours of fasting. Model: Nine obese men; randomized crossover with overnight fast, 72-hour fast, and fast plus GH blockade. Limitations: Hormone concentration is not a direct measure of anabolic flux. Evidence access: Primary abstract Substrate Metabolism and Insulin Sensitivity During Fasting in Obese Human Subjects: Impact of GH Blockade. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28324055/ · DOI 10.1210/jc.2016-3835
    Complete structured claim and evidence

  2. Arginine infusion increased GH, and its combination with GHRH produced a larger response than either stimulus alone.

    L-Arginine → Human growth hormone source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Six men; 30 g intravenous arginine and GHRH/TRH comparison tests.
    limitations
    Not an oral muscle-building outcome.
    nutrient_topic
    L-Arginine collection; tissue, species, dose and formulation distinctions retained. · L-Arginine
    plain_language
    A pharmacological infusion changed hormone release.
    primary_references
    Arginine stimulates growth hormone secretion by suppressing endogenous somatostatin secretion. · 1988 · https://pubmed.ncbi.nlm.nih.gov/2903866/ · DOI 10.1210/jcem-67-6-1186

    L-Arginine: transport, metabolic branches, nutrient interactions, availability and discovery questions (2026-09-18) · lines 326–332

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Six men; 30 g intravenous arginine and GHRH/TRH comparison tests. · source_derived_draft · unverified_draft

    ## arg-gh A pharmacological infusion changed hormone release. Arginine infusion increased GH, and its combination with GHRH produced a larger response than either stimulus alone. Model: Six men; 30 g intravenous arginine and GHRH/TRH comparison tests. Limitations: Not an oral muscle-building outcome. Evidence access: Primary abstract Arginine stimulates growth hormone secretion by suppressing endogenous somatostatin secretion. · 1988 · https://pubmed.ncbi.nlm.nih.gov/2903866/ · DOI 10.1210/jcem-67-6-1186
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. GH blockade abolished fasting-induced insulin resistance, mainly through reduced endogenous glucose production.

    Pegvisomant / growth-hormone receptor antagonist → Systemic insulin sensitivity source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Same nine-men protocol, hyperinsulinemic euglycemic clamp.
    limitations
    Acute adaptation during prolonged fasting differs from long-term diabetes outcomes.
    nutrient_topic
    Fasting physiological-state collection; human protocols, cellular deprivation and refeeding are distinguished. · Fasting / abstention from energy intake
    plain_language
    A counterregulatory hormone helped explain glucose sparing in this experiment.
    primary_references
    Substrate Metabolism and Insulin Sensitivity During Fasting in Obese Human Subjects: Impact of GH Blockade. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28324055/ · DOI 10.1210/jc.2016-3835

    Fasting: fuel switching, nutrient sensing, ketone signaling, nutrient dependencies and refeeding (2026-09-18) · lines 216–222

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Same nine-men protocol, hyperinsulinemic euglycemic clamp. · source_derived_draft · unverified_draft

    ## fast-gh-blockade A counterregulatory hormone helped explain glucose sparing in this experiment. GH blockade abolished fasting-induced insulin resistance, mainly through reduced endogenous glucose production. Model: Same nine-men protocol, hyperinsulinemic euglycemic clamp. Limitations: Acute adaptation during prolonged fasting differs from long-term diabetes outcomes. Evidence access: Primary abstract Substrate Metabolism and Insulin Sensitivity During Fasting in Obese Human Subjects: Impact of GH Blockade. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28324055/ · DOI 10.1210/jc.2016-3835
    Complete structured claim and evidence

  2. The authors inferred suppression of endogenous somatostatin from human stimulation tests and absent direct effects in rat pituitary cultures.

    L-Arginine → Somatostatin source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human challenge tests plus rat pituitary-cell experiments.
    limitations
    Somatostatin suppression was inferred, not directly measured; retained as a proposed mechanism.
    nutrient_topic
    L-Arginine collection; tissue, species, dose and formulation distinctions retained. · L-Arginine
    plain_language
    The proposed control point lies upstream of the pituitary response.
    primary_references
    Arginine stimulates growth hormone secretion by suppressing endogenous somatostatin secretion. · 1988 · https://pubmed.ncbi.nlm.nih.gov/2903866/ · DOI 10.1210/jcem-67-6-1186

    L-Arginine: transport, metabolic branches, nutrient interactions, availability and discovery questions (2026-09-18) · lines 334–340

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Human challenge tests plus rat pituitary-cell experiments. · source_derived_draft · unverified_draft

    ## arg-somatostatin The proposed control point lies upstream of the pituitary response. The authors inferred suppression of endogenous somatostatin from human stimulation tests and absent direct effects in rat pituitary cultures. Model: Human challenge tests plus rat pituitary-cell experiments. Limitations: Somatostatin suppression was inferred, not directly measured; retained as a proposed mechanism. Evidence access: Primary abstract Arginine stimulates growth hormone secretion by suppressing endogenous somatostatin secretion. · 1988 · https://pubmed.ncbi.nlm.nih.gov/2903866/ · DOI 10.1210/jcem-67-6-1186
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards