{"id":"50ac86e4-c24b-5644-8f77-b4f2efbe4aa6","stable_key":"18100170-a014-51c3-adeb-9dab4162b8cc:endocrine-growth-hormone","predicate":"increases_in_recorded_experiment","statement":"GH stimulated thymulin production in TEC preparations; IGF-I or IGF-I-receptor blockade inhibited the GH response.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"b9278db8-3d10-55cf-8d00-9a9f1bdcd4ae","mechanism_event_label":"GH stimulated thymulin production in TEC preparations; IGF-I or IGF-I-receptor blockade inhibited the GH response.","subject":{"id":"e71d7c2b-eba7-5167-91b7-df74dbca061a","slug":"growth-hormone","display_name":"Human growth hormone","entity_type_key":"protein"},"object":{"id":"23819462-9bdf-5856-beac-68b3dca9cf85","slug":"thymulin","display_name":"Thymulin","entity_type_key":"peptide"},"evidence_count":1,"mechanism_event":{"id":"b9278db8-3d10-55cf-8d00-9a9f1bdcd4ae","stable_key":"18100170-a014-51c3-adeb-9dab4162b8cc:endocrine-growth-hormone-event","event_type":"experimental_observation","label":"GH stimulated thymulin production in TEC preparations; IGF-I or IGF-I-receptor blockade inhibited the GH response.","description":"| GH and IGF-I | Both stimulated production in TEC preparations. Blocking IGF-I or its receptor inhibited the GH response, supporting a local IGF-mediated component. The associated human endocrine observations do not isolate that mechanism in vivo. [1992 study](https://pubmed.ncbi.nlm.nih.gov/1619008/) |","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e71d7c2b-eba7-5167-91b7-df74dbca061a","slug":"growth-hormone","display_name":"Human growth hormone","entity_type_key":"protein"},"role":"tested factor","stoichiometry":null,"state_label":"growth-hormone exposure","sequence_order":0,"notes":""},{"entity":{"id":"23819462-9bdf-5856-beac-68b3dca9cf85","slug":"thymulin","display_name":"Thymulin","entity_type_key":"peptide"},"role":"measured outcome","stoichiometry":null,"state_label":"increase","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary bibliographic record and abstract checked; full methods/figures not comprehensively reviewed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"growth-hormone exposure\", \"comparator\": \"Matched experimental control\", \"endpoint\": \"GH stimulated thymulin production in TEC preparations; IGF-I or IGF-I-receptor blockade inhibited the GH response.\", \"effect_direction\": \"increase\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; source-derived draft.","entity":null},{"dimension":"experimental_model","value_text":"Preparations and species as specified in statement and source; no direct iodine/selenium cofactor requirement inferred.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Interpret only within the recorded preparation, exposure and comparator. 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No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"GH stimulated thymulin production in TEC preparations; IGF-I or IGF-I-receptor blockade inhibited the GH response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Growth hormone and insulin-like growth factor-I stimulate hormonal function and proliferation of thymic epithelial cells. | 1992 | DOI 10.1210/jcem.75.1.1619008 | PMID 1619008 | https://pubmed.ncbi.nlm.nih.gov/1619008/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 93-93; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ef71f04e-93a4-58b8-bf2f-13dda506fc65","evidence_kind":"source_excerpt","locator":"Lines 93-93","start_line":93,"end_line":93,"excerpt":"| GH and IGF-I | Both stimulated production in TEC preparations. Blocking IGF-I or its receptor inhibited the GH response, supporting a local IGF-mediated component. The associated human endocrine observations do not isolate that mechanism in vivo. [1992 study](https://pubmed.ncbi.nlm.nih.gov/1619008/) |","model_system":"Preparations and species as specified in statement and source; no direct iodine/selenium cofactor requirement inferred.","directness":"reported_statement","verification_status":"source_recorded","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. 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