{"id":"69b0ee6f-b959-581b-abbd-d03f6b612e1a","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-gh","predicate":"increases","statement":"Arginine infusion increased GH, and its combination with GHRH produced a larger response than either stimulus alone.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"59892206-ac58-5be8-8cb5-0750578d5918","mechanism_event_label":"A pharmacological infusion changed hormone release.","subject":{"id":"eeca3c9e-7749-5677-b7bd-37fe8f7c228d","slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"},"object":{"id":"e71d7c2b-eba7-5167-91b7-df74dbca061a","slug":"growth-hormone","display_name":"Human growth hormone","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"59892206-ac58-5be8-8cb5-0750578d5918","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-gh-event","event_type":"observed_relationship","label":"A pharmacological infusion changed hormone release.","description":"Arginine infusion increased GH, and its combination with GHRH produced a larger response than either stimulus alone.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"eeca3c9e-7749-5677-b7bd-37fe8f7c228d","slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e71d7c2b-eba7-5167-91b7-df74dbca061a","slug":"growth-hormone","display_name":"Human growth hormone","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"db6459b5-095f-503c-b64d-11da0a9fd15b","slug":"ghrh","display_name":"Human growth hormone-releasing hormone","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Six men; 30 g intravenous arginine and GHRH/TRH comparison tests.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not an oral muscle-building outcome.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Arginine collection; tissue, species, dose and formulation distinctions retained.","comparator":null,"unit":null,"notes":"","entity":{"slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A pharmacological infusion changed hormone release.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Arginine stimulates growth hormone secretion by suppressing endogenous somatostatin secretion. · 1988 · https://pubmed.ncbi.nlm.nih.gov/2903866/ · DOI 10.1210/jcem-67-6-1186","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"390f2406-ff00-57d1-b2f9-be8c0e91aa87","evidence_kind":"source_excerpt","locator":"Lines 326-332","start_line":326,"end_line":332,"excerpt":"## arg-gh\nA pharmacological infusion changed hormone release.\nArginine infusion increased GH, and its combination with GHRH produced a larger response than either stimulus alone.\nModel: Six men; 30 g intravenous arginine and GHRH/TRH comparison tests.\nLimitations: Not an oral muscle-building outcome.\nEvidence access: Primary abstract\nArginine stimulates growth hormone secretion by suppressing endogenous somatostatin secretion. · 1988 · https://pubmed.ncbi.nlm.nih.gov/2903866/ · DOI 10.1210/jcem-67-6-1186","model_system":"Six men; 30 g intravenous arginine and GHRH/TRH comparison tests.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; primary evidence access stated per claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"bb9a67ea-904f-5b8a-93a4-459081212bdd","stable_key":"import-fd37d270-3395-56d6-9f1c-ddda56e606f6","title":"L-Arginine: transport, metabolic branches, nutrient interactions, availability and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"ec0e9a3fb72b7485534e4372a074ac7624a399ff962e55690eb462217b5149ec","revision_id":"af027270-5535-51ae-85ff-9c76c518c962","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}