{"id":"a771909b-82a9-5395-879c-903e1a026117","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-somatostatin","predicate":"proposed_to_suppress","statement":"The authors inferred suppression of endogenous somatostatin from human stimulation tests and absent direct effects in rat pituitary cultures.","claim_class":"hypothesis_link","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"8c63a9ee-8b95-5df9-a553-ed2185ce98fb","mechanism_event_label":"The proposed control point lies upstream of the pituitary response.","subject":{"id":"eeca3c9e-7749-5677-b7bd-37fe8f7c228d","slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"},"object":{"id":"2fafc373-8aca-5bb3-aa12-4569c400b65c","slug":"somatostatin","display_name":"Somatostatin","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"8c63a9ee-8b95-5df9-a553-ed2185ce98fb","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-somatostatin-event","event_type":"observed_relationship","label":"The proposed control point lies upstream of the pituitary response.","description":"The authors inferred suppression of endogenous somatostatin from human stimulation tests and absent direct effects in rat pituitary cultures.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"eeca3c9e-7749-5677-b7bd-37fe8f7c228d","slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2fafc373-8aca-5bb3-aa12-4569c400b65c","slug":"somatostatin","display_name":"Somatostatin","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e71d7c2b-eba7-5167-91b7-df74dbca061a","slug":"growth-hormone","display_name":"Human growth hormone","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"db6459b5-095f-503c-b64d-11da0a9fd15b","slug":"ghrh","display_name":"Human growth hormone-releasing hormone","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human challenge tests plus rat pituitary-cell experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Somatostatin suppression was inferred, not directly measured; retained as a proposed mechanism.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Arginine collection; tissue, species, dose and formulation distinctions retained.","comparator":null,"unit":null,"notes":"","entity":{"slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The proposed control point lies upstream of the pituitary response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Arginine stimulates growth hormone secretion by suppressing endogenous somatostatin secretion. · 1988 · https://pubmed.ncbi.nlm.nih.gov/2903866/ · DOI 10.1210/jcem-67-6-1186","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"58ff7812-78c3-5bf4-94f6-5ff887f1162d","evidence_kind":"source_excerpt","locator":"Lines 334-340","start_line":334,"end_line":340,"excerpt":"## arg-somatostatin\nThe proposed control point lies upstream of the pituitary response.\nThe authors inferred suppression of endogenous somatostatin from human stimulation tests and absent direct effects in rat pituitary cultures.\nModel: Human challenge tests plus rat pituitary-cell experiments.\nLimitations: Somatostatin suppression was inferred, not directly measured; retained as a proposed mechanism.\nEvidence access: Primary abstract\nArginine stimulates growth hormone secretion by suppressing endogenous somatostatin secretion. · 1988 · https://pubmed.ncbi.nlm.nih.gov/2903866/ · DOI 10.1210/jcem-67-6-1186","model_system":"Human challenge tests plus rat pituitary-cell experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; primary evidence access stated per claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"bb9a67ea-904f-5b8a-93a4-459081212bdd","stable_key":"import-fd37d270-3395-56d6-9f1c-ddda56e606f6","title":"L-Arginine: transport, metabolic branches, nutrient interactions, availability and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"ec0e9a3fb72b7485534e4372a074ac7624a399ff962e55690eb462217b5149ec","revision_id":"af027270-5535-51ae-85ff-9c76c518c962","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}