Component

A GABA-enriched food or supplement preparation

A GABA-enriched food or supplement preparation. Species, exposure and limitations are retained in each linked claim.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Eighty subjects with systolic blood pressure 130 to 159 millimetres of mercury or diastolic 85 to 99 took GABA-rich Chlorella supplying 20 milligrams as gamma-aminobutyric acid or placebo twice daily for 12 weeks with follow-up for an additional 4 weeks, systolic blood pressure in the subjects given GABA-rich Chlorella significantly decreased compared with placebo, diastolic blood pressure had the tendency to decrease, neither adverse events nor abnormal laboratory findings were reported, and reduction of systolic pressure in the subjects with borderline hypertension was higher than in those with high-normal blood pressure.

    A GABA-enriched food or supplement preparation → Systolic blood pressure source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/gaba-research/19811362.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f372e3ce2c34cf5dcbac79af1c003b562d14665f547fab69748c5ee625c34886", "start_char": 0, "end_char": 1307, "text_sha256": "f372e3ce2c34cf5dcbac79af1c003b562d14665f547fab69748c5ee625c34886"}
    experimental_model
    Placebo-controlled double-blind study over twelve weeks with four weeks of follow-up
    exposure
    GABA-rich Chlorella supplying 20 milligrams of GABA twice daily against placebo
    limitations
    Eighty subjects with high-normal or borderline blood pressure. The intervention is a whole algal preparation, so the effect is not attributable to GABA alone.
    nutrient_topic
    GABA research collection; topical membership is not evidence of a direct clinical effect, and the sign of a GABA response depends on the chloride gradient of the cell it was measured in. · Gamma-aminobutyric acid
    organism
    Human
    plain_language
    Twelve weeks of a GABA-rich algal supplement lowered the upper blood pressure reading.
    primary_references
    [gb-p19811362] Anti-hypertensive effect of gamma-aminobutyric acid (GABA)-rich Chlorella on high-normal blood pressure and borderline hypertension in placebo-controlled double blind study. (2009). https://pubmed.ncbi.nlm.nih.gov/19811362/ DOI: 10.1080/10641960902977908
    tissue_or_cell_type
    Systemic circulation

    GABA: a ligand with no sign of its own, the cofactor that limits its synthesis, the barrier that keeps it out of the brain, and the immune settings where the same molecule protects and harms (2026-09-22) · lines 378–389

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Placebo-controlled double-blind study over twelve weeks with four weeks of follow-up · source_derived_draft · unverified_draft

    ### gb-an-algal-preparation-lowered-pressure Eighty subjects with systolic blood pressure 130 to 159 millimetres of mercury or diastolic 85 to 99 took GABA-rich Chlorella supplying 20 milligrams as gamma-aminobutyric acid or placebo twice daily for 12 weeks with follow-up for an additional 4 weeks, systolic blood pressure in the subjects given GABA-rich Chlorella significantly decreased compared with placebo, diastolic blood pressure had the tendency to decrease, neither adverse events nor abnormal laboratory findings were reported, and reduction of systolic pressure in the subjects with borderline hypertension was higher than in those with high-normal blood pressure. Condition category: normal nutrient_topic: GABA research collection; topical membership is not evidence of a direct clinical effect, and the sign of a GABA response depends on the chloride gradient of the cell it was measured in. plain_language: Twelve weeks of a GABA-rich algal supplement lowered the upper blood pressure reading. organism: Human tissue_or_cell_type: Systemic circulation experimental_model: Placebo-controlled double-blind study over twelve weeks with four weeks of follow-up limitations: Eighty subjects with high-normal or borderline blood pressure. The intervention is a whole algal preparation, so the effect is not attributable to GABA alone. exposure: GABA-rich Chlorella supplying 20 milligrams of GABA twice daily against placebo evidence_span: {"source_cache": "artifacts/gaba-research/19811362.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f372e3ce2c34cf5dcbac79af1c003b562d14665f547fab69748c5ee625c34886", "start_char": 0, "end_char": 1307, "text_sha256": "f372e3ce2c34cf5dcbac79af1c003b562d14665f547fab69748c5ee625c34886"} [gb-p19811362] Anti-hypertensive effect of gamma-aminobutyric acid (GABA)-rich Chlorella on high-normal blood pressure and borderline hypertension in placebo-controlled double blind study. (2009). https://pubmed.ncbi.nlm.nih.gov/19811362/ DOI: 10.1080/10641960902977908
    Complete structured claim and evidence

  2. In 39 mildly hypertensive adults divided into a test group of 22 who consumed rice with 11.2 milligrams GABA per 100 grams and a placebo group of 17 who consumed rice with 2.7 milligrams per 100 grams for 8 weeks, although the hospital blood pressure and evening blood pressure measurements of the participants showed no significant change, consumption of the GABA rice improved the morning blood pressure compared with the placebo rice after the first week and during the sixth and eighth weeks.

    A GABA-enriched food or supplement preparation → Self-measured morning blood pressure source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/gaba-research/26870683.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9567c5c241e58810e0ccbf83890474aeffb6ea63198864ba199bee68708482e4", "start_char": 0, "end_char": 1173, "text_sha256": "9567c5c241e58810e0ccbf83890474aeffb6ea63198864ba199bee68708482e4"}
    experimental_model
    Randomised double-blind placebo-controlled study with home self-measured blood pressure over eight weeks
    exposure
    White rice enriched to 11.2 milligrams GABA per 100 grams against rice with 2.7 milligrams per 100 grams, 150 grams daily
    limitations
    Thirty-nine mildly hypertensive adults. Hospital and evening blood pressure did not change, so the positive result is confined to one of the three measurement settings.
    nutrient_topic
    GABA research collection; topical membership is not evidence of a direct clinical effect, and the sign of a GABA response depends on the chloride gradient of the cell it was measured in. · Gamma-aminobutyric acid
    organism
    Human
    plain_language
    Enriched rice moved the morning readings and left the clinic and evening readings alone.
    primary_references
    [gb-p26870683] Effects of white rice containing enriched gamma-aminobutyric acid on blood pressure. (2016). https://pubmed.ncbi.nlm.nih.gov/26870683/ DOI: 10.1016/j.jtcme.2014.11.022
    tissue_or_cell_type
    Systemic circulation

    GABA: a ligand with no sign of its own, the cofactor that limits its synthesis, the barrier that keeps it out of the brain, and the immune settings where the same molecule protects and harms (2026-09-22) · lines 365–376

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomised double-blind placebo-controlled study with home self-measured blood pressure over eight weeks · source_derived_draft · unverified_draft

    ### gb-only-morning-pressure-moved In 39 mildly hypertensive adults divided into a test group of 22 who consumed rice with 11.2 milligrams GABA per 100 grams and a placebo group of 17 who consumed rice with 2.7 milligrams per 100 grams for 8 weeks, although the hospital blood pressure and evening blood pressure measurements of the participants showed no significant change, consumption of the GABA rice improved the morning blood pressure compared with the placebo rice after the first week and during the sixth and eighth weeks. Condition category: normal nutrient_topic: GABA research collection; topical membership is not evidence of a direct clinical effect, and the sign of a GABA response depends on the chloride gradient of the cell it was measured in. plain_language: Enriched rice moved the morning readings and left the clinic and evening readings alone. organism: Human tissue_or_cell_type: Systemic circulation experimental_model: Randomised double-blind placebo-controlled study with home self-measured blood pressure over eight weeks limitations: Thirty-nine mildly hypertensive adults. Hospital and evening blood pressure did not change, so the positive result is confined to one of the three measurement settings. exposure: White rice enriched to 11.2 milligrams GABA per 100 grams against rice with 2.7 milligrams per 100 grams, 150 grams daily evidence_span: {"source_cache": "artifacts/gaba-research/26870683.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "9567c5c241e58810e0ccbf83890474aeffb6ea63198864ba199bee68708482e4", "start_char": 0, "end_char": 1173, "text_sha256": "9567c5c241e58810e0ccbf83890474aeffb6ea63198864ba199bee68708482e4"} [gb-p26870683] Effects of white rice containing enriched gamma-aminobutyric acid on blood pressure. (2016). https://pubmed.ncbi.nlm.nih.gov/26870683/ DOI: 10.1016/j.jtcme.2014.11.022
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. The first study evaluated the effect of GABA intake by 13 subjects on their brain waves, with electroencephalograms obtained after three tests on each volunteer taking only water, GABA, or L-theanine, and after 60 minutes of administration GABA significantly increased alpha waves and decreased beta waves compared to water or L-theanine, while in a second study eight acrophobic subjects crossing a suspended bridge as a stressful stimulus showed a marked decrease of salivary immunoglobulin A in the placebo group while the GABA group showed significantly higher levels.

    Gamma-aminobutyric acid → Electroencephalographic alpha and beta wave power source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/gaba-research/16971751.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f0958495814a3c685efcafef73349d34248a2648872afa7e4a92c93132d9b631", "start_char": 0, "end_char": 1322, "text_sha256": "f0958495814a3c685efcafef73349d34248a2648872afa7e4a92c93132d9b631"}
    experimental_model
    Two small studies: electroencephalography after a single intake, and salivary immunoglobulin during a stressor
    exposure
    Orally administered GABA against water and against L-theanine, and GABA against placebo in acrophobic subjects crossing a suspended bridge
    limitations
    Thirteen subjects in the first study and eight in the second, with no correction for multiple comparisons reported. The immunity claim rests on salivary immunoglobulin A in eight people.
    nutrient_topic
    GABA research collection; topical membership is not evidence of a direct clinical effect, and the sign of a GABA response depends on the chloride gradient of the cell it was measured in. · Gamma-aminobutyric acid
    organism
    Human
    plain_language
    A gram taken by mouth changed the pattern of brain waves within an hour in thirteen people.
    primary_references
    [gb-p16971751] Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans. (2006). https://pubmed.ncbi.nlm.nih.gov/16971751/ DOI: 10.1002/biof.5520260305
    tissue_or_cell_type
    Brain electrical activity and saliva

    GABA: a ligand with no sign of its own, the cofactor that limits its synthesis, the barrier that keeps it out of the brain, and the immune settings where the same molecule protects and harms (2026-09-22) · lines 352–363

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Two small studies: electroencephalography after a single intake, and salivary immunoglobulin during a stressor · source_derived_draft · unverified_draft

    ### gb-oral-gaba-shifts-the-eeg The first study evaluated the effect of GABA intake by 13 subjects on their brain waves, with electroencephalograms obtained after three tests on each volunteer taking only water, GABA, or L-theanine, and after 60 minutes of administration GABA significantly increased alpha waves and decreased beta waves compared to water or L-theanine, while in a second study eight acrophobic subjects crossing a suspended bridge as a stressful stimulus showed a marked decrease of salivary immunoglobulin A in the placebo group while the GABA group showed significantly higher levels. Condition category: normal nutrient_topic: GABA research collection; topical membership is not evidence of a direct clinical effect, and the sign of a GABA response depends on the chloride gradient of the cell it was measured in. plain_language: A gram taken by mouth changed the pattern of brain waves within an hour in thirteen people. organism: Human tissue_or_cell_type: Brain electrical activity and saliva experimental_model: Two small studies: electroencephalography after a single intake, and salivary immunoglobulin during a stressor limitations: Thirteen subjects in the first study and eight in the second, with no correction for multiple comparisons reported. The immunity claim rests on salivary immunoglobulin A in eight people. exposure: Orally administered GABA against water and against L-theanine, and GABA against placebo in acrophobic subjects crossing a suspended bridge evidence_span: {"source_cache": "artifacts/gaba-research/16971751.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "f0958495814a3c685efcafef73349d34248a2648872afa7e4a92c93132d9b631", "start_char": 0, "end_char": 1322, "text_sha256": "f0958495814a3c685efcafef73349d34248a2648872afa7e4a92c93132d9b631"} [gb-p16971751] Relaxation and immunity enhancement effects of gamma-aminobutyric acid (GABA) administration in humans. (2006). https://pubmed.ncbi.nlm.nih.gov/16971751/ DOI: 10.1002/biof.5520260305
    Complete structured claim and evidence

  2. In volunteers with mildly or moderately high blood pressure, both the fermented drinking water containing gamma-aminobutyric acid and the placebo drink of vinegar and dried bonito without GABA significantly decreased systolic blood pressure by 7.6 plus or minus 4.0 and 5.5 plus or minus 1.5 millimetres of mercury respectively and diastolic by 10.6 plus or minus 4.0 and 7.6 plus or minus 1.7 millimetres of mercury respectively compared to baseline at 12 weeks, there were no abnormal changes in haematological or blood chemistry variables, and these findings indicated that vinegar and dried bonito with or without GABA might have an effect on blood pressure.

    The fermented vinegar and dried bonito drink without added GABA → Systolic blood pressure source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/gaba-research/19590713.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "cf28abaa2c4005e26679a43d2ee25123d4ca6fb7184943a6b8c7e0529e560e4a", "start_char": 0, "end_char": 1206, "text_sha256": "cf28abaa2c4005e26679a43d2ee25123d4ca6fb7184943a6b8c7e0529e560e4a"}
    experimental_model
    Double-blind placebo-controlled randomised study with the same fermented drink prepared with and without GABA
    exposure
    Fermented drinking water from sodium glutamate, vinegar and dried bonito, against the identical drink without GABA
    limitations
    The control is the same food matrix minus the GABA, which is the comparison the other blood-pressure studies lack.
    nutrient_topic
    GABA research collection; topical membership is not evidence of a direct clinical effect, and the sign of a GABA response depends on the chloride gradient of the cell it was measured in. · Gamma-aminobutyric acid
    organism
    Human
    plain_language
    The drink without any GABA in it lowered blood pressure too, which is what the other trials had no way of detecting.
    primary_references
    [gb-p19590713] The Effects of gamma-Aminobutyric Acid, Vinegar, and Dried Bonito on Blood Pressure in Normotensive and Mildly or Moderately Hypertensive Volunteers. (2009). https://pubmed.ncbi.nlm.nih.gov/19590713/ DOI: 10.3164/jcbn.09-04
    tissue_or_cell_type
    Systemic circulation

    GABA: a ligand with no sign of its own, the cofactor that limits its synthesis, the barrier that keeps it out of the brain, and the immune settings where the same molecule protects and harms (2026-09-22) · lines 391–402

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Double-blind placebo-controlled randomised study with the same fermented drink prepared with and without GABA · source_derived_draft · unverified_draft

    ### gb-the-control-worked-too In volunteers with mildly or moderately high blood pressure, both the fermented drinking water containing gamma-aminobutyric acid and the placebo drink of vinegar and dried bonito without GABA significantly decreased systolic blood pressure by 7.6 plus or minus 4.0 and 5.5 plus or minus 1.5 millimetres of mercury respectively and diastolic by 10.6 plus or minus 4.0 and 7.6 plus or minus 1.7 millimetres of mercury respectively compared to baseline at 12 weeks, there were no abnormal changes in haematological or blood chemistry variables, and these findings indicated that vinegar and dried bonito with or without GABA might have an effect on blood pressure. Condition category: normal nutrient_topic: GABA research collection; topical membership is not evidence of a direct clinical effect, and the sign of a GABA response depends on the chloride gradient of the cell it was measured in. plain_language: The drink without any GABA in it lowered blood pressure too, which is what the other trials had no way of detecting. organism: Human tissue_or_cell_type: Systemic circulation experimental_model: Double-blind placebo-controlled randomised study with the same fermented drink prepared with and without GABA limitations: The control is the same food matrix minus the GABA, which is the comparison the other blood-pressure studies lack. exposure: Fermented drinking water from sodium glutamate, vinegar and dried bonito, against the identical drink without GABA evidence_span: {"source_cache": "artifacts/gaba-research/19590713.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "cf28abaa2c4005e26679a43d2ee25123d4ca6fb7184943a6b8c7e0529e560e4a", "start_char": 0, "end_char": 1206, "text_sha256": "cf28abaa2c4005e26679a43d2ee25123d4ca6fb7184943a6b8c7e0529e560e4a"} [gb-p19590713] The Effects of gamma-Aminobutyric Acid, Vinegar, and Dried Bonito on Blood Pressure in Normotensive and Mildly or Moderately Hypertensive Volunteers. (2009). https://pubmed.ncbi.nlm.nih.gov/19590713/ DOI: 10.3164/jcbn.09-04
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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