{"id":"2936a795-8ef1-59cc-b4e3-bb644fab58cc","stable_key":"1b599eb7-b22a-5fda-bcf0-9d92b5ae1311:gb-only-morning-pressure-moved","predicate":"reduces","statement":"In 39 mildly hypertensive adults divided into a test group of 22 who consumed rice with 11.2 milligrams GABA per 100 grams and a placebo group of 17 who consumed rice with 2.7 milligrams per 100 grams for 8 weeks, although the hospital blood pressure and evening blood pressure measurements of the participants showed no significant change, consumption of the GABA rice improved the morning blood pressure compared with the placebo rice after the first week and during the sixth and eighth weeks.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"5e02888c-8728-5061-96d1-52d845732194","mechanism_event_label":"Enriched rice moved the morning readings and left the clinic and evening readings alone.","subject":{"id":"2ef146a7-26e4-5546-9acf-4eddcce5db95","slug":"gaba-enriched-food","display_name":"A GABA-enriched food or supplement preparation","entity_type_key":"chemical_species"},"object":{"id":"2a29a3d2-1d4a-5ca9-bca4-236c38754959","slug":"morning-blood-pressure","display_name":"Self-measured morning blood pressure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5e02888c-8728-5061-96d1-52d845732194","stable_key":"1b599eb7-b22a-5fda-bcf0-9d92b5ae1311:gb-only-morning-pressure-moved-event","event_type":"observed_intervention","label":"Enriched rice moved the morning readings and left the clinic and evening readings alone.","description":"In 39 mildly hypertensive adults divided into a test group of 22 who consumed rice with 11.2 milligrams GABA per 100 grams and a placebo group of 17 who consumed rice with 2.7 milligrams per 100 grams for 8 weeks, although the hospital blood pressure and evening blood pressure measurements of the participants showed no significant change, consumption of the GABA rice improved the morning blood pressure compared with the placebo rice after the first week and during the sixth and eighth weeks.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8fc0ee41-c9a7-52d4-aebe-418a5307d96d","slug":"systolic-blood-pressure","display_name":"Systolic blood pressure","entity_type_key":"cellular_process"},"role":"related_measure","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2ef146a7-26e4-5546-9acf-4eddcce5db95","slug":"gaba-enriched-food","display_name":"A GABA-enriched food or supplement preparation","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2a29a3d2-1d4a-5ca9-bca4-236c38754959","slug":"morning-blood-pressure","display_name":"Self-measured morning blood pressure","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/gaba-research/26870683.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"9567c5c241e58810e0ccbf83890474aeffb6ea63198864ba199bee68708482e4\", \"start_char\": 0, \"end_char\": 1173, \"text_sha256\": \"9567c5c241e58810e0ccbf83890474aeffb6ea63198864ba199bee68708482e4\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomised double-blind placebo-controlled study with home self-measured blood pressure over eight weeks","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"White rice enriched to 11.2 milligrams GABA per 100 grams against rice with 2.7 milligrams per 100 grams, 150 grams daily","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Thirty-nine mildly hypertensive adults. Hospital and evening blood pressure did not change, so the positive result is confined to one of the three measurement settings.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"GABA research collection; topical membership is not evidence of a direct clinical effect, and the sign of a GABA response depends on the chloride gradient of the cell it was measured in.","comparator":null,"unit":null,"notes":"","entity":{"slug":"gaba","display_name":"Gamma-aminobutyric acid","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Enriched rice moved the morning readings and left the clinic and evening readings alone.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[gb-p26870683] Effects of white rice containing enriched gamma-aminobutyric acid on blood pressure. (2016). https://pubmed.ncbi.nlm.nih.gov/26870683/ DOI: 10.1016/j.jtcme.2014.11.022","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Systemic circulation","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"54f13387-ed66-57e7-ad18-bbe3c0490abc","evidence_kind":"source_excerpt","locator":"Lines 365-376","start_line":365,"end_line":376,"excerpt":"### gb-only-morning-pressure-moved\nIn 39 mildly hypertensive adults divided into a test group of 22 who consumed rice with 11.2 milligrams GABA per 100 grams and a placebo group of 17 who consumed rice with 2.7 milligrams per 100 grams for 8 weeks, although the hospital blood pressure and evening blood pressure measurements of the participants showed no significant change, consumption of the GABA rice improved the morning blood pressure compared with the placebo rice after the first week and during the sixth and eighth weeks.\nCondition category: normal\nnutrient_topic: GABA research collection; topical membership is not evidence of a direct clinical effect, and the sign of a GABA response depends on the chloride gradient of the cell it was measured in.\nplain_language: Enriched rice moved the morning readings and left the clinic and evening readings alone.\norganism: Human\ntissue_or_cell_type: Systemic circulation\nexperimental_model: Randomised double-blind placebo-controlled study with home self-measured blood pressure over eight weeks\nlimitations: Thirty-nine mildly hypertensive adults. Hospital and evening blood pressure did not change, so the positive result is confined to one of the three measurement settings.\nexposure: White rice enriched to 11.2 milligrams GABA per 100 grams against rice with 2.7 milligrams per 100 grams, 150 grams daily\nevidence_span: {\"source_cache\": \"artifacts/gaba-research/26870683.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"9567c5c241e58810e0ccbf83890474aeffb6ea63198864ba199bee68708482e4\", \"start_char\": 0, \"end_char\": 1173, \"text_sha256\": \"9567c5c241e58810e0ccbf83890474aeffb6ea63198864ba199bee68708482e4\"}\n[gb-p26870683] Effects of white rice containing enriched gamma-aminobutyric acid on blood pressure. (2016). https://pubmed.ncbi.nlm.nih.gov/26870683/ DOI: 10.1016/j.jtcme.2014.11.022","model_system":"Randomised double-blind placebo-controlled study with home self-measured blood pressure over eight weeks","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [gb-p26870683] Effects of white rice containing enriched gamma-aminobutyric acid on blood pressure. (2016). https://pubmed.ncbi.nlm.nih.gov/26870683/ DOI: 10.1016/j.jtcme.2014.11.022","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"197c25bb-45fa-5e97-b3ab-2d2eff4e0d0a","stable_key":"import-1b599eb7-b22a-5fda-bcf0-9d92b5ae1311","title":"GABA: a ligand with no sign of its own, the cofactor that limits its synthesis, the barrier that keeps it out of the brain, and the immune settings where the same molecule protects and harms (2026-09-22)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"07e36027ff70dbbe5563cddfa4758fd9b9b6eec148faecccafd476900b770456","revision_id":"a12d61de-f189-5bda-af3d-f31a1e61bccf","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}