Component
The fermented vinegar and dried bonito drink without added GABA
The fermented vinegar and dried bonito drink without added GABA. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What it acts on
In volunteers with mildly or moderately high blood pressure, both the fermented drinking water containing gamma-aminobutyric acid and the placebo drink of vinegar and dried bonito without GABA significantly decreased systolic blood pressure by 7.6 plus or minus 4.0 and 5.5 plus or minus 1.5 millimetres of mercury respectively and diastolic by 10.6 plus or minus 4.0 and 7.6 plus or minus 1.7 millimetres of mercury respectively compared to baseline at 12 weeks, there were no abnormal changes in haematological or blood chemistry variables, and these findings indicated that vinegar and dried bonito with or without GABA might have an effect on blood pressure.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/gaba-research/19590713.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "cf28abaa2c4005e26679a43d2ee25123d4ca6fb7184943a6b8c7e0529e560e4a", "start_char": 0, "end_char": 1206, "text_sha256": "cf28abaa2c4005e26679a43d2ee25123d4ca6fb7184943a6b8c7e0529e560e4a"}
- experimental_model
- Double-blind placebo-controlled randomised study with the same fermented drink prepared with and without GABA
- exposure
- Fermented drinking water from sodium glutamate, vinegar and dried bonito, against the identical drink without GABA
- limitations
- The control is the same food matrix minus the GABA, which is the comparison the other blood-pressure studies lack.
- nutrient_topic
- GABA research collection; topical membership is not evidence of a direct clinical effect, and the sign of a GABA response depends on the chloride gradient of the cell it was measured in. · Gamma-aminobutyric acid
- organism
- Human
- plain_language
- The drink without any GABA in it lowered blood pressure too, which is what the other trials had no way of detecting.
- primary_references
- [gb-p19590713] The Effects of gamma-Aminobutyric Acid, Vinegar, and Dried Bonito on Blood Pressure in Normotensive and Mildly or Moderately Hypertensive Volunteers. (2009). https://pubmed.ncbi.nlm.nih.gov/19590713/ DOI: 10.3164/jcbn.09-04
- tissue_or_cell_type
- Systemic circulation
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Double-blind placebo-controlled randomised study with the same fermented drink prepared with and without GABA · source_derived_draft · unverified_draft
### gb-the-control-worked-too In volunteers with mildly or moderately high blood pressure, both the fermented drinking water containing gamma-aminobutyric acid and the placebo drink of vinegar and dried bonito without GABA significantly decreased systolic blood pressure by 7.6 plus or minus 4.0 and 5.5 plus or minus 1.5 millimetres of mercury respectively and diastolic by 10.6 plus or minus 4.0 and 7.6 plus or minus 1.7 millimetres of mercury respectively compared to baseline at 12 weeks, there were no abnormal changes in haematological or blood chemistry variables, and these findings indicated that vinegar and dried bonito with or without GABA might have an effect on blood pressure. Condition category: normal nutrient_topic: GABA research collection; topical membership is not evidence of a direct clinical effect, and the sign of a GABA response depends on the chloride gradient of the cell it was measured in. plain_language: The drink without any GABA in it lowered blood pressure too, which is what the other trials had no way of detecting. organism: Human tissue_or_cell_type: Systemic circulation experimental_model: Double-blind placebo-controlled randomised study with the same fermented drink prepared with and without GABA limitations: The control is the same food matrix minus the GABA, which is the comparison the other blood-pressure studies lack. exposure: Fermented drinking water from sodium glutamate, vinegar and dried bonito, against the identical drink without GABA evidence_span: {"source_cache": "artifacts/gaba-research/19590713.abstract.txt", "locator": "Indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "cf28abaa2c4005e26679a43d2ee25123d4ca6fb7184943a6b8c7e0529e560e4a", "start_char": 0, "end_char": 1206, "text_sha256": "cf28abaa2c4005e26679a43d2ee25123d4ca6fb7184943a6b8c7e0529e560e4a"} [gb-p19590713] The Effects of gamma-Aminobutyric Acid, Vinegar, and Dried Bonito on Blood Pressure in Normotensive and Mildly or Moderately Hypertensive Volunteers. (2009). https://pubmed.ncbi.nlm.nih.gov/19590713/ DOI: 10.3164/jcbn.09-04
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.