{"id":"5ec2b668-d163-5a4b-bdf1-c9ee1499f213","stable_key":"1b599eb7-b22a-5fda-bcf0-9d92b5ae1311:gb-an-algal-preparation-lowered-pressure","predicate":"reduces","statement":"Eighty subjects with systolic blood pressure 130 to 159 millimetres of mercury or diastolic 85 to 99 took GABA-rich Chlorella supplying 20 milligrams as gamma-aminobutyric acid or placebo twice daily for 12 weeks with follow-up for an additional 4 weeks, systolic blood pressure in the subjects given GABA-rich Chlorella significantly decreased compared with placebo, diastolic blood pressure had the tendency to decrease, neither adverse events nor abnormal laboratory findings were reported, and reduction of systolic pressure in the subjects with borderline hypertension was higher than in those with high-normal blood pressure.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"9e80f05d-6aa1-5181-acf0-534107496cdf","mechanism_event_label":"Twelve weeks of a GABA-rich algal supplement lowered the upper blood pressure reading.","subject":{"id":"2ef146a7-26e4-5546-9acf-4eddcce5db95","slug":"gaba-enriched-food","display_name":"A GABA-enriched food or supplement preparation","entity_type_key":"chemical_species"},"object":{"id":"8fc0ee41-c9a7-52d4-aebe-418a5307d96d","slug":"systolic-blood-pressure","display_name":"Systolic blood pressure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9e80f05d-6aa1-5181-acf0-534107496cdf","stable_key":"1b599eb7-b22a-5fda-bcf0-9d92b5ae1311:gb-an-algal-preparation-lowered-pressure-event","event_type":"observed_intervention","label":"Twelve weeks of a GABA-rich algal supplement lowered the upper blood pressure reading.","description":"Eighty subjects with systolic blood pressure 130 to 159 millimetres of mercury or diastolic 85 to 99 took GABA-rich Chlorella supplying 20 milligrams as gamma-aminobutyric acid or placebo twice daily for 12 weeks with follow-up for an additional 4 weeks, systolic blood pressure in the subjects given GABA-rich Chlorella significantly decreased compared with placebo, diastolic blood pressure had the tendency to decrease, neither adverse events nor abnormal laboratory findings were reported, and reduction of systolic pressure in the subjects with borderline hypertension was higher than in those with high-normal blood pressure.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d5b98fa8-0612-5a5a-aa3c-6cfd8ff88867","slug":"gaba","display_name":"Gamma-aminobutyric acid","entity_type_key":"small_molecule"},"role":"named_constituent","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2ef146a7-26e4-5546-9acf-4eddcce5db95","slug":"gaba-enriched-food","display_name":"A GABA-enriched food or supplement preparation","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8fc0ee41-c9a7-52d4-aebe-418a5307d96d","slug":"systolic-blood-pressure","display_name":"Systolic blood pressure","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/gaba-research/19811362.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"f372e3ce2c34cf5dcbac79af1c003b562d14665f547fab69748c5ee625c34886\", \"start_char\": 0, \"end_char\": 1307, \"text_sha256\": \"f372e3ce2c34cf5dcbac79af1c003b562d14665f547fab69748c5ee625c34886\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Placebo-controlled double-blind study over twelve weeks with four weeks of follow-up","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"GABA-rich Chlorella supplying 20 milligrams of GABA twice daily against placebo","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Eighty subjects with high-normal or borderline blood pressure. The intervention is a whole algal preparation, so the effect is not attributable to GABA alone.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"GABA research collection; topical membership is not evidence of a direct clinical effect, and the sign of a GABA response depends on the chloride gradient of the cell it was measured in.","comparator":null,"unit":null,"notes":"","entity":{"slug":"gaba","display_name":"Gamma-aminobutyric acid","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Twelve weeks of a GABA-rich algal supplement lowered the upper blood pressure reading.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[gb-p19811362] Anti-hypertensive effect of gamma-aminobutyric acid (GABA)-rich Chlorella on high-normal blood pressure and borderline hypertension in placebo-controlled double blind study. (2009). https://pubmed.ncbi.nlm.nih.gov/19811362/ DOI: 10.1080/10641960902977908","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Systemic circulation","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e8e39529-ec01-51a5-881a-d7615b69da23","evidence_kind":"source_excerpt","locator":"Lines 378-389","start_line":378,"end_line":389,"excerpt":"### gb-an-algal-preparation-lowered-pressure\nEighty subjects with systolic blood pressure 130 to 159 millimetres of mercury or diastolic 85 to 99 took GABA-rich Chlorella supplying 20 milligrams as gamma-aminobutyric acid or placebo twice daily for 12 weeks with follow-up for an additional 4 weeks, systolic blood pressure in the subjects given GABA-rich Chlorella significantly decreased compared with placebo, diastolic blood pressure had the tendency to decrease, neither adverse events nor abnormal laboratory findings were reported, and reduction of systolic pressure in the subjects with borderline hypertension was higher than in those with high-normal blood pressure.\nCondition category: normal\nnutrient_topic: GABA research collection; topical membership is not evidence of a direct clinical effect, and the sign of a GABA response depends on the chloride gradient of the cell it was measured in.\nplain_language: Twelve weeks of a GABA-rich algal supplement lowered the upper blood pressure reading.\norganism: Human\ntissue_or_cell_type: Systemic circulation\nexperimental_model: Placebo-controlled double-blind study over twelve weeks with four weeks of follow-up\nlimitations: Eighty subjects with high-normal or borderline blood pressure. The intervention is a whole algal preparation, so the effect is not attributable to GABA alone.\nexposure: GABA-rich Chlorella supplying 20 milligrams of GABA twice daily against placebo\nevidence_span: {\"source_cache\": \"artifacts/gaba-research/19811362.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"f372e3ce2c34cf5dcbac79af1c003b562d14665f547fab69748c5ee625c34886\", \"start_char\": 0, \"end_char\": 1307, \"text_sha256\": \"f372e3ce2c34cf5dcbac79af1c003b562d14665f547fab69748c5ee625c34886\"}\n[gb-p19811362] Anti-hypertensive effect of gamma-aminobutyric acid (GABA)-rich Chlorella on high-normal blood pressure and borderline hypertension in placebo-controlled double blind study. (2009). https://pubmed.ncbi.nlm.nih.gov/19811362/ DOI: 10.1080/10641960902977908","model_system":"Placebo-controlled double-blind study over twelve weeks with four weeks of follow-up","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [gb-p19811362] Anti-hypertensive effect of gamma-aminobutyric acid (GABA)-rich Chlorella on high-normal blood pressure and borderline hypertension in placebo-controlled double blind study. 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