Component

Ferret beta-carotene oxygenase 2 / BCO2

Ferret beta-carotene oxygenase 2 / BCO2. Species, exposure and limitations are retained in each linked claim.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Ferret BCO2 also cleaved 13-cis lycopene to apo-10-prime-lycopenal.

    Ferret beta-carotene oxygenase 2 / BCO2 → Apo-10-prime-lycopenal source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/lycopene-research/16672231.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "135695c9d3106469d8d64ec0806ba5bf048f0f1df6f3e3cd53e838e50b960445", "start_char": 0, "end_char": 1967, "text_sha256": "135695c9d3106469d8d64ec0806ba5bf048f0f1df6f3e3cd53e838e50b960445"}
    experimental_model
    Recombinant ferret enzyme and tissue-fraction metabolism
    exposure
    5-cis, 13-cis and all-trans lycopene; iron; NAD+ or NADH
    limitations
    Ferret experiments do not quantify human cleavage flux or predict supplement response.
    nutrient_topic
    Lycopene research collection; topical membership is not evidence of a direct dietary effect. · Lycopene
    organism
    Ferret
    plain_language
    Another cis form entered the same measured cleavage route.
    primary_references
    [lycopene-p16672231] The biochemical characterization of ferret carotene-9',10'-monooxygenase catalyzing cleavage of carotenoids in vitro and in vivo. (2006). https://pubmed.ncbi.nlm.nih.gov/16672231/ DOI: 10.1074/jbc.m512095200
    tissue_or_cell_type
    BCO2 enzyme; hepatic fractions and lung

    Lycopene: absorption, metabolism, nutrient connections and human outcomes (2026-09-17) · lines 299–310

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Recombinant ferret enzyme and tissue-fraction metabolism · source_derived_draft · unverified_draft

    ### lycopene-bco2-13cis Ferret BCO2 also cleaved 13-cis lycopene to apo-10-prime-lycopenal. Condition category: normal nutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect. plain_language: Another cis form entered the same measured cleavage route. organism: Ferret tissue_or_cell_type: BCO2 enzyme; hepatic fractions and lung experimental_model: Recombinant ferret enzyme and tissue-fraction metabolism limitations: Ferret experiments do not quantify human cleavage flux or predict supplement response. exposure: 5-cis, 13-cis and all-trans lycopene; iron; NAD+ or NADH evidence_span: {"source_cache": "artifacts/lycopene-research/16672231.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "135695c9d3106469d8d64ec0806ba5bf048f0f1df6f3e3cd53e838e50b960445", "start_char": 0, "end_char": 1967, "text_sha256": "135695c9d3106469d8d64ec0806ba5bf048f0f1df6f3e3cd53e838e50b960445"} [lycopene-p16672231] The biochemical characterization of ferret carotene-9',10'-monooxygenase catalyzing cleavage of carotenoids in vitro and in vivo. (2006). https://pubmed.ncbi.nlm.nih.gov/16672231/ DOI: 10.1074/jbc.m512095200
    Complete structured claim and evidence

  2. Ferret BCO2 cleaved 5-cis lycopene at the 9-prime,10-prime bond to apo-10-prime-lycopenal.

    Ferret beta-carotene oxygenase 2 / BCO2 → Apo-10-prime-lycopenal source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/lycopene-research/16672231.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "135695c9d3106469d8d64ec0806ba5bf048f0f1df6f3e3cd53e838e50b960445", "start_char": 0, "end_char": 1967, "text_sha256": "135695c9d3106469d8d64ec0806ba5bf048f0f1df6f3e3cd53e838e50b960445"}
    experimental_model
    Recombinant ferret enzyme and tissue-fraction metabolism
    exposure
    5-cis, 13-cis and all-trans lycopene; iron; NAD+ or NADH
    limitations
    Ferret experiments do not quantify human cleavage flux or predict supplement response.
    nutrient_topic
    Lycopene research collection; topical membership is not evidence of a direct dietary effect. · Lycopene
    organism
    Ferret
    plain_language
    An enzyme can cut a bent lycopene molecule into a smaller signaling candidate.
    primary_references
    [lycopene-p16672231] The biochemical characterization of ferret carotene-9',10'-monooxygenase catalyzing cleavage of carotenoids in vitro and in vivo. (2006). https://pubmed.ncbi.nlm.nih.gov/16672231/ DOI: 10.1074/jbc.m512095200
    tissue_or_cell_type
    BCO2 enzyme; hepatic fractions and lung

    Lycopene: absorption, metabolism, nutrient connections and human outcomes (2026-09-17) · lines 286–297

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Recombinant ferret enzyme and tissue-fraction metabolism · source_derived_draft · unverified_draft

    ### lycopene-bco2-5cis Ferret BCO2 cleaved 5-cis lycopene at the 9-prime,10-prime bond to apo-10-prime-lycopenal. Condition category: normal nutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect. plain_language: An enzyme can cut a bent lycopene molecule into a smaller signaling candidate. organism: Ferret tissue_or_cell_type: BCO2 enzyme; hepatic fractions and lung experimental_model: Recombinant ferret enzyme and tissue-fraction metabolism limitations: Ferret experiments do not quantify human cleavage flux or predict supplement response. exposure: 5-cis, 13-cis and all-trans lycopene; iron; NAD+ or NADH evidence_span: {"source_cache": "artifacts/lycopene-research/16672231.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "135695c9d3106469d8d64ec0806ba5bf048f0f1df6f3e3cd53e838e50b960445", "start_char": 0, "end_char": 1967, "text_sha256": "135695c9d3106469d8d64ec0806ba5bf048f0f1df6f3e3cd53e838e50b960445"} [lycopene-p16672231] The biochemical characterization of ferret carotene-9',10'-monooxygenase catalyzing cleavage of carotenoids in vitro and in vivo. (2006). https://pubmed.ncbi.nlm.nih.gov/16672231/ DOI: 10.1074/jbc.m512095200
    Complete structured claim and evidence

  3. All-trans lycopene was not cleaved by ferret BCO2 under the reported conditions.

    Ferret beta-carotene oxygenase 2 / BCO2 → All-trans-lycopene / all-E-lycopene source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/lycopene-research/16672231.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "135695c9d3106469d8d64ec0806ba5bf048f0f1df6f3e3cd53e838e50b960445", "start_char": 0, "end_char": 1967, "text_sha256": "135695c9d3106469d8d64ec0806ba5bf048f0f1df6f3e3cd53e838e50b960445"}
    experimental_model
    Recombinant ferret enzyme and tissue-fraction metabolism
    exposure
    5-cis, 13-cis and all-trans lycopene; iron; NAD+ or NADH
    limitations
    Ferret experiments do not quantify human cleavage flux or predict supplement response.
    nutrient_topic
    Lycopene research collection; topical membership is not evidence of a direct dietary effect. · Lycopene
    organism
    Ferret
    plain_language
    The straight form did not behave like the cis forms in this enzyme assay.
    primary_references
    [lycopene-p16672231] The biochemical characterization of ferret carotene-9',10'-monooxygenase catalyzing cleavage of carotenoids in vitro and in vivo. (2006). https://pubmed.ncbi.nlm.nih.gov/16672231/ DOI: 10.1074/jbc.m512095200
    tissue_or_cell_type
    BCO2 enzyme; hepatic fractions and lung

    Lycopene: absorption, metabolism, nutrient connections and human outcomes (2026-09-17) · lines 312–323

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Recombinant ferret enzyme and tissue-fraction metabolism · source_derived_draft · unverified_draft

    ### lycopene-bco2-trans-null All-trans lycopene was not cleaved by ferret BCO2 under the reported conditions. Condition category: normal nutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect. plain_language: The straight form did not behave like the cis forms in this enzyme assay. organism: Ferret tissue_or_cell_type: BCO2 enzyme; hepatic fractions and lung experimental_model: Recombinant ferret enzyme and tissue-fraction metabolism limitations: Ferret experiments do not quantify human cleavage flux or predict supplement response. exposure: 5-cis, 13-cis and all-trans lycopene; iron; NAD+ or NADH evidence_span: {"source_cache": "artifacts/lycopene-research/16672231.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "135695c9d3106469d8d64ec0806ba5bf048f0f1df6f3e3cd53e838e50b960445", "start_char": 0, "end_char": 1967, "text_sha256": "135695c9d3106469d8d64ec0806ba5bf048f0f1df6f3e3cd53e838e50b960445"} [lycopene-p16672231] The biochemical characterization of ferret carotene-9',10'-monooxygenase catalyzing cleavage of carotenoids in vitro and in vivo. (2006). https://pubmed.ncbi.nlm.nih.gov/16672231/ DOI: 10.1074/jbc.m512095200
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Iron was an essential cofactor for lycopene cleavage by recombinant ferret BCO2.

    Ferrous iron → Ferret BCO2 lycopene cleavage activity source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/lycopene-research/16672231.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "135695c9d3106469d8d64ec0806ba5bf048f0f1df6f3e3cd53e838e50b960445", "start_char": 0, "end_char": 1967, "text_sha256": "135695c9d3106469d8d64ec0806ba5bf048f0f1df6f3e3cd53e838e50b960445"}
    experimental_model
    Recombinant ferret enzyme and tissue-fraction metabolism
    exposure
    5-cis, 13-cis and all-trans lycopene; iron; NAD+ or NADH
    limitations
    Ferret experiments do not quantify human cleavage flux or predict supplement response.
    nutrient_topic
    Lycopene research collection; topical membership is not evidence of a direct dietary effect. · Lycopene
    organism
    Ferret
    plain_language
    The cleavage machinery has a mineral requirement.
    primary_references
    [lycopene-p16672231] The biochemical characterization of ferret carotene-9',10'-monooxygenase catalyzing cleavage of carotenoids in vitro and in vivo. (2006). https://pubmed.ncbi.nlm.nih.gov/16672231/ DOI: 10.1074/jbc.m512095200
    tissue_or_cell_type
    BCO2 enzyme; hepatic fractions and lung

    Lycopene: absorption, metabolism, nutrient connections and human outcomes (2026-09-17) · lines 325–336

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Recombinant ferret enzyme and tissue-fraction metabolism · source_derived_draft · unverified_draft

    ### lycopene-bco2-iron Iron was an essential cofactor for lycopene cleavage by recombinant ferret BCO2. Condition category: normal nutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect. plain_language: The cleavage machinery has a mineral requirement. organism: Ferret tissue_or_cell_type: BCO2 enzyme; hepatic fractions and lung experimental_model: Recombinant ferret enzyme and tissue-fraction metabolism limitations: Ferret experiments do not quantify human cleavage flux or predict supplement response. exposure: 5-cis, 13-cis and all-trans lycopene; iron; NAD+ or NADH evidence_span: {"source_cache": "artifacts/lycopene-research/16672231.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "135695c9d3106469d8d64ec0806ba5bf048f0f1df6f3e3cd53e838e50b960445", "start_char": 0, "end_char": 1967, "text_sha256": "135695c9d3106469d8d64ec0806ba5bf048f0f1df6f3e3cd53e838e50b960445"} [lycopene-p16672231] The biochemical characterization of ferret carotene-9',10'-monooxygenase catalyzing cleavage of carotenoids in vitro and in vivo. (2006). https://pubmed.ncbi.nlm.nih.gov/16672231/ DOI: 10.1074/jbc.m512095200
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards