Component

Dephosphorylated uncarboxylated matrix Gla protein

Dephosphorylated uncarboxylated matrix Gla protein. Species, exposure and limitations are retained in each linked claim.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. dp-ucMGP changed by -212 pmol/L with MK-7 plus vitamin D versus +45 pmol/L with placebo.

    Menaquinone-7 / MK-7 → Dephosphorylated uncarboxylated matrix Gla protein source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/k2-research/35465686.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0bd565b58d0e78923a55d154f6a341de560d5674c63989d36042543e0ddc295c", "start_char": 0, "end_char": 2233, "text_sha256": "0bd565b58d0e78923a55d154f6a341de560d5674c63989d36042543e0ddc295c"}
    experimental_model
    Two-year randomized double-blind AVADEC trial
    exposure
    MK-7 720 micrograms plus vitamin D 25 micrograms/day versus placebo
    limitations
    Combined intervention, valve-disease population; neither K2-only effects nor universal prevention claims follow.
    nutrient_topic
    Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin K2 / menaquinone family
    organism
    365 men, mean age 71, with aortic-valve calcium score above 300
    plain_language
    A biochemical response coexisted with a null valve-imaging result.
    primary_references
    [k2-p35465686] Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial. (2022). https://pubmed.ncbi.nlm.nih.gov/35465686/ DOI: 10.1161/circulationaha.121.057008
    tissue_or_cell_type
    Valve CT, echocardiography and dp-ucMGP

    Vitamin K2: menaquinone forms, carboxylation, recycling and nutrient interactions (2026-09-17) · lines 1215–1226

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Two-year randomized double-blind AVADEC trial · source_derived_draft · unverified_draft

    ### k2-avadec-marker dp-ucMGP changed by -212 pmol/L with MK-7 plus vitamin D versus +45 pmol/L with placebo. Condition category: normal nutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. plain_language: A biochemical response coexisted with a null valve-imaging result. organism: 365 men, mean age 71, with aortic-valve calcium score above 300 tissue_or_cell_type: Valve CT, echocardiography and dp-ucMGP experimental_model: Two-year randomized double-blind AVADEC trial limitations: Combined intervention, valve-disease population; neither K2-only effects nor universal prevention claims follow. exposure: MK-7 720 micrograms plus vitamin D 25 micrograms/day versus placebo evidence_span: {"source_cache": "artifacts/k2-research/35465686.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0bd565b58d0e78923a55d154f6a341de560d5674c63989d36042543e0ddc295c", "start_char": 0, "end_char": 2233, "text_sha256": "0bd565b58d0e78923a55d154f6a341de560d5674c63989d36042543e0ddc295c"} [k2-p35465686] Vitamin K2 and D in Patients With Aortic Valve Calcification: A Randomized Double-Blinded Clinical Trial. (2022). https://pubmed.ncbi.nlm.nih.gov/35465686/ DOI: 10.1161/circulationaha.121.057008
    Complete structured claim and evidence

  2. MK-7 reduced dp-ucMGP versus placebo by 205.6 pmol/L in the diabetes/CVD trial.

    Menaquinone-7 / MK-7 → Dephosphorylated uncarboxylated matrix Gla protein source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/k2-research/31387121.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "669c0cd660524535123c231e46bba36d26e632210055aa863a3601f3c7da9621", "start_char": 0, "end_char": 2207, "text_sha256": "669c0cd660524535123c231e46bba36d26e632210055aa863a3601f3c7da9621"}
    experimental_model
    Six-month randomized double-blind trial
    exposure
    MK-7 360 micrograms/day
    limitations
    Small trial, 60 completed; PET activity and CT calcium mass are distinct. A nonsignificant trend is not a demonstrated increase in disease.
    nutrient_topic
    Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin K2 / menaquinone family
    organism
    68 adults with type 2 diabetes and established cardiovascular disease
    plain_language
    A vitamin K-related biomarker responded to treatment.
    primary_references
    [k2-p31387121] The effect of menaquinone-7 supplementation on vascular calcification in patients with diabetes: a randomized, double-blind, placebo-controlled trial. (2019). https://pubmed.ncbi.nlm.nih.gov/31387121/ DOI: 10.1093/ajcn/nqz147
    tissue_or_cell_type
    Femoral fluorine-18 NaF PET and CT

    Vitamin K2: menaquinone forms, carboxylation, recycling and nutrient interactions (2026-09-17) · lines 1176–1187

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Six-month randomized double-blind trial · source_derived_draft · unverified_draft

    ### k2-diabetes-marker MK-7 reduced dp-ucMGP versus placebo by 205.6 pmol/L in the diabetes/CVD trial. Condition category: normal nutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. plain_language: A vitamin K-related biomarker responded to treatment. organism: 68 adults with type 2 diabetes and established cardiovascular disease tissue_or_cell_type: Femoral fluorine-18 NaF PET and CT experimental_model: Six-month randomized double-blind trial limitations: Small trial, 60 completed; PET activity and CT calcium mass are distinct. A nonsignificant trend is not a demonstrated increase in disease. exposure: MK-7 360 micrograms/day evidence_span: {"source_cache": "artifacts/k2-research/31387121.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "669c0cd660524535123c231e46bba36d26e632210055aa863a3601f3c7da9621", "start_char": 0, "end_char": 2207, "text_sha256": "669c0cd660524535123c231e46bba36d26e632210055aa863a3601f3c7da9621"} [k2-p31387121] The effect of menaquinone-7 supplementation on vascular calcification in patients with diabetes: a randomized, double-blind, placebo-controlled trial. (2019). https://pubmed.ncbi.nlm.nih.gov/31387121/ DOI: 10.1093/ajcn/nqz147
    Complete structured claim and evidence

  3. MK-7 reduced dp-ucMGP by about 50% but did not change the measured acute-phase or endothelial-dysfunction markers.

    Menaquinone-7 / MK-7 → Dephosphorylated uncarboxylated matrix Gla protein source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/k2-research/25694037.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "744049d613c87cb18fd3fe9cf3d7242e3c424a8d463900701bee102d4072b8e3", "start_char": 0, "end_char": 1822, "text_sha256": "744049d613c87cb18fd3fe9cf3d7242e3c424a8d463900701bee102d4072b8e3"}
    experimental_model
    Three-year randomized double-blind trial
    exposure
    MK-7 180 micrograms/day
    limitations
    Same cohort as the bone publication; stiffness is not CT calcification or cardiovascular-event incidence.
    nutrient_topic
    Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin K2 / menaquinone family
    organism
    244 healthy postmenopausal women
    plain_language
    Different blood markers responded differently.
    primary_references
    [k2-p25694037] Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial. (2015). https://pubmed.ncbi.nlm.nih.gov/25694037/ DOI: 10.1160/th14-08-0675
    tissue_or_cell_type
    Arterial stiffness and circulating proteins

    Vitamin K2: menaquinone forms, carboxylation, recycling and nutrient interactions (2026-09-17) · lines 1163–1174

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Three-year randomized double-blind trial · source_derived_draft · unverified_draft

    ### k2-mk7-dpucmgp MK-7 reduced dp-ucMGP by about 50% but did not change the measured acute-phase or endothelial-dysfunction markers. Condition category: normal nutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. plain_language: Different blood markers responded differently. organism: 244 healthy postmenopausal women tissue_or_cell_type: Arterial stiffness and circulating proteins experimental_model: Three-year randomized double-blind trial limitations: Same cohort as the bone publication; stiffness is not CT calcification or cardiovascular-event incidence. exposure: MK-7 180 micrograms/day evidence_span: {"source_cache": "artifacts/k2-research/25694037.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "744049d613c87cb18fd3fe9cf3d7242e3c424a8d463900701bee102d4072b8e3", "start_char": 0, "end_char": 1822, "text_sha256": "744049d613c87cb18fd3fe9cf3d7242e3c424a8d463900701bee102d4072b8e3"} [k2-p25694037] Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. A double-blind randomised clinical trial. (2015). https://pubmed.ncbi.nlm.nih.gov/25694037/ DOI: 10.1160/th14-08-0675
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Acenocoumarol increased uncarboxylated factor II, osteocalcin and dp-ucMGP and reduced endogenous thrombin generation.

    Acenocoumarol → Undercarboxylated prothrombin / PIVKA-II source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/k2-research/23530987.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "95455ea6f2fc6de10ed4d46cad9c1587c004ccd445d7b08066108261f161e6af", "start_char": 0, "end_char": 1740, "text_sha256": "95455ea6f2fc6de10ed4d46cad9c1587c004ccd445d7b08066108261f161e6af"}
    experimental_model
    Sequential dose-response intervention during anticoagulation
    exposure
    Acenocoumarol followed by MK-7 10, 20 and 45 micrograms/day
    limitations
    Small pharmacological study; no dose here is a recommended safe self-adjustment. Drug was acenocoumarol, not warfarin.
    nutrient_topic
    Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. · Vitamin K2 / menaquinone family
    organism
    18 healthy adults; 15 attained target INR
    plain_language
    The drug changed several proteins that share the same vitamin K cycle.
    primary_references
    [k2-p23530987] Effect of low-dose supplements of menaquinone-7 (vitamin K2 ) on the stability of oral anticoagulant treatment: dose-response relationship in healthy volunteers. (2013). https://pubmed.ncbi.nlm.nih.gov/23530987/ DOI: 10.1111/jth.12203
    tissue_or_cell_type
    Coagulation, osteocalcin and MGP markers
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Vitamin K2: menaquinone forms, carboxylation, recycling and nutrient interactions (2026-09-17) · lines 1033–1044

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Sequential dose-response intervention during anticoagulation · source_derived_draft · unverified_draft

    ### k2-acenocoumarol-markers Acenocoumarol increased uncarboxylated factor II, osteocalcin and dp-ucMGP and reduced endogenous thrombin generation. Condition category: machinery_impairment nutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect. plain_language: The drug changed several proteins that share the same vitamin K cycle. organism: 18 healthy adults; 15 attained target INR tissue_or_cell_type: Coagulation, osteocalcin and MGP markers experimental_model: Sequential dose-response intervention during anticoagulation limitations: Small pharmacological study; no dose here is a recommended safe self-adjustment. Drug was acenocoumarol, not warfarin. exposure: Acenocoumarol followed by MK-7 10, 20 and 45 micrograms/day evidence_span: {"source_cache": "artifacts/k2-research/23530987.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "95455ea6f2fc6de10ed4d46cad9c1587c004ccd445d7b08066108261f161e6af", "start_char": 0, "end_char": 1740, "text_sha256": "95455ea6f2fc6de10ed4d46cad9c1587c004ccd445d7b08066108261f161e6af"} [k2-p23530987] Effect of low-dose supplements of menaquinone-7 (vitamin K2 ) on the stability of oral anticoagulant treatment: dose-response relationship in healthy volunteers. (2013). https://pubmed.ncbi.nlm.nih.gov/23530987/ DOI: 10.1111/jth.12203
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards