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A nonsignificant trend is not a demonstrated increase in disease.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"k2","display_name":"Vitamin K2 / menaquinone family","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"68 adults with type 2 diabetes and established cardiovascular disease","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A vitamin K-related biomarker responded to treatment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[k2-p31387121] The effect of menaquinone-7 supplementation on vascular calcification in patients with diabetes: a randomized, double-blind, placebo-controlled trial. (2019). https://pubmed.ncbi.nlm.nih.gov/31387121/ DOI: 10.1093/ajcn/nqz147","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Femoral fluorine-18 NaF PET and CT","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"df64c0b7-e30d-57c8-aded-2c5c4103cc56","evidence_kind":"source_excerpt","locator":"Lines 1176-1187","start_line":1176,"end_line":1187,"excerpt":"### k2-diabetes-marker\nMK-7 reduced dp-ucMGP versus placebo by 205.6 pmol/L in the diabetes/CVD trial.\nCondition category: normal\nnutrient_topic: Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A vitamin K-related biomarker responded to treatment.\norganism: 68 adults with type 2 diabetes and established cardiovascular disease\ntissue_or_cell_type: Femoral fluorine-18 NaF PET and CT\nexperimental_model: Six-month randomized double-blind trial\nlimitations: Small trial, 60 completed; PET activity and CT calcium mass are distinct. A nonsignificant trend is not a demonstrated increase in disease.\nexposure: MK-7 360 micrograms/day\nevidence_span: {\"source_cache\": \"artifacts/k2-research/31387121.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"669c0cd660524535123c231e46bba36d26e632210055aa863a3601f3c7da9621\", \"start_char\": 0, \"end_char\": 2207, \"text_sha256\": \"669c0cd660524535123c231e46bba36d26e632210055aa863a3601f3c7da9621\"}\n[k2-p31387121] The effect of menaquinone-7 supplementation on vascular calcification in patients with diabetes: a randomized, double-blind, placebo-controlled trial. (2019). https://pubmed.ncbi.nlm.nih.gov/31387121/ DOI: 10.1093/ajcn/nqz147","model_system":"Six-month randomized double-blind trial","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [k2-p31387121] The effect of menaquinone-7 supplementation on vascular calcification in patients with diabetes: a randomized, double-blind, placebo-controlled trial. (2019). https://pubmed.ncbi.nlm.nih.gov/31387121/ DOI: 10.1093/ajcn/nqz147","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dfeae572-af3d-5042-a10e-e67596f9ab28","stable_key":"import-4fef8d72-f107-5eb5-b2fb-483ca85465e0","title":"Vitamin K2: menaquinone forms, carboxylation, recycling and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"dc31aff21110d09b025c177e03b4c5ca8349d52bf5f962285fdbfcf660c0e4f6","revision_id":"850887db-34f6-55aa-9d3e-b8fd3a4a5de3","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}