{"id":"36cc9be6-a677-5cc6-8aca-59df9a26c449","stable_key":"4fef8d72-f107-5eb5-b2fb-483ca85465e0:k2-mk7-dpucmgp","predicate":"reduces","statement":"MK-7 reduced dp-ucMGP by about 50% but did not change the measured acute-phase or endothelial-dysfunction markers.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2658e19b-69a3-55a3-8e0a-c38b696530ca","mechanism_event_label":"Different blood markers responded differently.","subject":{"id":"a3ff2a7b-69f3-5098-8fac-fb8d7668397b","slug":"menaquinone-7","display_name":"Menaquinone-7 / MK-7","entity_type_key":"small_molecule"},"object":{"id":"ec71ae5c-0e8f-5bc4-b80c-06306e7663fd","slug":"dp-ucmgp","display_name":"Dephosphorylated uncarboxylated matrix Gla protein","entity_type_key":"protein_state"},"evidence_count":1,"mechanism_event":{"id":"2658e19b-69a3-55a3-8e0a-c38b696530ca","stable_key":"4fef8d72-f107-5eb5-b2fb-483ca85465e0:k2-mk7-dpucmgp-event","event_type":"observed_intervention","label":"Different blood markers responded differently.","description":"MK-7 reduced dp-ucMGP by about 50% but did not change the measured acute-phase or endothelial-dysfunction markers.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a3ff2a7b-69f3-5098-8fac-fb8d7668397b","slug":"menaquinone-7","display_name":"Menaquinone-7 / MK-7","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ec71ae5c-0e8f-5bc4-b80c-06306e7663fd","slug":"dp-ucmgp","display_name":"Dephosphorylated uncarboxylated matrix Gla protein","entity_type_key":"protein_state"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/k2-research/25694037.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"744049d613c87cb18fd3fe9cf3d7242e3c424a8d463900701bee102d4072b8e3\", \"start_char\": 0, \"end_char\": 1822, \"text_sha256\": \"744049d613c87cb18fd3fe9cf3d7242e3c424a8d463900701bee102d4072b8e3\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Three-year randomized double-blind trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"MK-7 180 micrograms/day","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Same cohort as the bone publication; stiffness is not CT calcification or cardiovascular-event incidence.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin K2 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"k2","display_name":"Vitamin K2 / menaquinone family","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"244 healthy postmenopausal women","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Different blood markers responded differently.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[k2-p25694037] Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women. 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