Component

Human diacylglycerol kinase eta / DGKH

Context-specific entity; species, compartment and exposure are stated on each claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. DGK-eta siRNA reduced CLA-induced IL-8 and MCP-1 expression and JNK/c-Jun activation.

    Human diacylglycerol kinase eta / DGKH → Human adipocyte CLA-associated cytokine output source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human adipocyte RNA-interference experiment.
    limitations
    Partial effects do not establish an exclusive pathway.
    nutrient_topic
    CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
    plain_language
    Gene depletion supported a contribution by a specific enzyme.
    primary_references
    Diacylglycerol kinase inhibitor R59022 attenuates conjugated linoleic acid-mediated inflammation in human adipocytes. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23264678/ · DOI 10.1194/jlr.M031211

    Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 190–196

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Human adipocyte RNA-interference experiment. · source_derived_draft · unverified_draft

    ## cla-dgkh-knockdown Gene depletion supported a contribution by a specific enzyme. DGK-eta siRNA reduced CLA-induced IL-8 and MCP-1 expression and JNK/c-Jun activation. Model: Human adipocyte RNA-interference experiment. Limitations: Partial effects do not establish an exclusive pathway. Evidence access: Primary abstract Diacylglycerol kinase inhibitor R59022 attenuates conjugated linoleic acid-mediated inflammation in human adipocytes. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23264678/ · DOI 10.1194/jlr.M031211
    Complete structured claim and evidence

What acts on it

  1. Adding t10,c12 CLA induced DGK-eta expression in primary human adipocytes.

    trans-10,cis-12 conjugated linoleic acid → Human diacylglycerol kinase eta / DGKH source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Primary human adipocyte expression study.
    limitations
    Expression alone does not demonstrate increased catalytic flux.
    nutrient_topic
    CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
    plain_language
    Another lipid-signaling enzyme responded to CLA.
    primary_references
    Diacylglycerol kinase inhibitor R59022 attenuates conjugated linoleic acid-mediated inflammation in human adipocytes. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23264678/ · DOI 10.1194/jlr.M031211

    Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 182–188

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Primary human adipocyte expression study. · source_derived_draft · unverified_draft

    ## cla-dgkh-expression Another lipid-signaling enzyme responded to CLA. Adding t10,c12 CLA induced DGK-eta expression in primary human adipocytes. Model: Primary human adipocyte expression study. Limitations: Expression alone does not demonstrate increased catalytic flux. Evidence access: Primary abstract Diacylglycerol kinase inhibitor R59022 attenuates conjugated linoleic acid-mediated inflammation in human adipocytes. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23264678/ · DOI 10.1194/jlr.M031211
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. DGK inhibitor R59022 attenuated CLA-induced calcium accumulation and reductions in glucose/fatty-acid uptake.

    R59022, pharmacological DGK inhibitor → Human adipocyte intracellular calcium response source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Primary human adipocytes, R59022 pretreatment.
    limitations
    The inhibitor does not establish DGK-eta as the calcium-controlling isoform.
    nutrient_topic
    CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
    plain_language
    Pharmacological results connected lipid signaling and calcium.
    primary_references
    Diacylglycerol kinase inhibitor R59022 attenuates conjugated linoleic acid-mediated inflammation in human adipocytes. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23264678/ · DOI 10.1194/jlr.M031211

    Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 198–204

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Primary human adipocytes, R59022 pretreatment. · source_derived_draft · unverified_draft

    ## cla-dgk-inhibitor Pharmacological results connected lipid signaling and calcium. DGK inhibitor R59022 attenuated CLA-induced calcium accumulation and reductions in glucose/fatty-acid uptake. Model: Primary human adipocytes, R59022 pretreatment. Limitations: The inhibitor does not establish DGK-eta as the calcium-controlling isoform. Evidence access: Primary abstract Diacylglycerol kinase inhibitor R59022 attenuates conjugated linoleic acid-mediated inflammation in human adipocytes. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23264678/ · DOI 10.1194/jlr.M031211
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards