Component

Circulating chromium concentration

Circulating chromium concentration. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. The neonatal study found no relation of measured plasma or urinary chromium to its assessed laboratory parameters or morbidity.

    Circulating chromium concentration → Neonatal morbidity measurements source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/chromium-research/39898458.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1776af33c0e684df33140b02e64d6cb2b4fa727cc167e6b17662e0f4c74275c7", "start_char": 0, "end_char": 1530, "text_sha256": "1776af33c0e684df33140b02e64d6cb2b4fa727cc167e6b17662e0f4c74275c7"}
    experimental_model
    Prospective observational study; 97 very-low-birthweight infants
    exposure
    Parenteral nutrition without added chromium from day 1; plasma days 15/30 and urine day 30
    limitations
    No added chromium does not mean zero exposure because components can contain chromium. Observational biomarker findings do not establish adequacy thresholds or universal neonatal dosing guidance.
    nutrient_topic
    Chromium research collection; topical membership is not evidence of a direct dietary effect. · Chromium
    organism
    Human premature infants
    plain_language
    The measured chromium differences were not linked to the reported clinical outcomes.
    primary_references
    [chromium-p39898458] Chromium-free parenteral nutrition and its effects on chromium levels in very low birth weight infants. (2025). https://pubmed.ncbi.nlm.nih.gov/39898458/ DOI: 10.20960/nh.05609
    tissue_or_cell_type
    Plasma and urine during neonatal nutrition
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Chromium: transport, insulin signaling, nutrient interactions and essentiality debate (2026-09-17) · lines 939–950

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Prospective observational study; 97 very-low-birthweight infants · source_derived_draft · unverified_draft

    ### chromium-neonatal-marker-outcome-null The neonatal study found no relation of measured plasma or urinary chromium to its assessed laboratory parameters or morbidity. Condition category: biomarker_context nutrient_topic: Chromium research collection; topical membership is not evidence of a direct dietary effect. plain_language: The measured chromium differences were not linked to the reported clinical outcomes. organism: Human premature infants tissue_or_cell_type: Plasma and urine during neonatal nutrition experimental_model: Prospective observational study; 97 very-low-birthweight infants limitations: No added chromium does not mean zero exposure because components can contain chromium. Observational biomarker findings do not establish adequacy thresholds or universal neonatal dosing guidance. exposure: Parenteral nutrition without added chromium from day 1; plasma days 15/30 and urine day 30 evidence_span: {"source_cache": "artifacts/chromium-research/39898458.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1776af33c0e684df33140b02e64d6cb2b4fa727cc167e6b17662e0f4c74275c7", "start_char": 0, "end_char": 1530, "text_sha256": "1776af33c0e684df33140b02e64d6cb2b4fa727cc167e6b17662e0f4c74275c7"} [chromium-p39898458] Chromium-free parenteral nutrition and its effects on chromium levels in very low birth weight infants. (2025). https://pubmed.ncbi.nlm.nih.gov/39898458/ DOI: 10.20960/nh.05609
    Complete structured claim and evidence

What acts on it

  1. High dietary iron reduced serum, liver and kidney chromium concentrations in the study.

    Iron → Circulating chromium concentration source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/chromium-research/29164513.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4d99145cb86f4110fd0087f9162fa057d87b445b9bc6a60c6467bb310f5e300b", "start_char": 0, "end_char": 2450, "text_sha256": "4d99145cb86f4110fd0087f9162fa057d87b445b9bc6a60c6467bb310f5e300b"}
    experimental_model
    Factorial six-group iron-excess/chromium feeding experiment
    exposure
    Iron 45 versus 180 mg/kg diet; chromium propionate 1, 50 or 500 mg Cr/kg diet; six animals/group
    limitations
    High-dose animal study. The direction changed with background iron; do not extrapolate a universal nutrient antagonism or human dose ratio.
    nutrient_topic
    Chromium research collection; topical membership is not evidence of a direct dietary effect. · Chromium
    organism
    Female Wistar rats
    plain_language
    Excess iron changed chromium distribution under these rat feeding conditions.
    primary_references
    [chromium-p29164513] The Combined Effects of Iron Excess in the Diet and Chromium(III) Supplementation on the Iron and Chromium Status in Female Rats. (2018). https://pubmed.ncbi.nlm.nih.gov/29164513/ DOI: 10.1007/s12011-017-1203-z
    tissue_or_cell_type
    Serum, liver and kidney metals

    Chromium: transport, insulin signaling, nutrient interactions and essentiality debate (2026-09-17) · lines 510–521

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Factorial six-group iron-excess/chromium feeding experiment · source_derived_draft · unverified_draft

    ### chromium-iron-excess-chromium High dietary iron reduced serum, liver and kidney chromium concentrations in the study. Condition category: normal nutrient_topic: Chromium research collection; topical membership is not evidence of a direct dietary effect. plain_language: Excess iron changed chromium distribution under these rat feeding conditions. organism: Female Wistar rats tissue_or_cell_type: Serum, liver and kidney metals experimental_model: Factorial six-group iron-excess/chromium feeding experiment limitations: High-dose animal study. The direction changed with background iron; do not extrapolate a universal nutrient antagonism or human dose ratio. exposure: Iron 45 versus 180 mg/kg diet; chromium propionate 1, 50 or 500 mg Cr/kg diet; six animals/group evidence_span: {"source_cache": "artifacts/chromium-research/29164513.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "4d99145cb86f4110fd0087f9162fa057d87b445b9bc6a60c6467bb310f5e300b", "start_char": 0, "end_char": 2450, "text_sha256": "4d99145cb86f4110fd0087f9162fa057d87b445b9bc6a60c6467bb310f5e300b"} [chromium-p29164513] The Combined Effects of Iron Excess in the Diet and Chromium(III) Supplementation on the Iron and Chromium Status in Female Rats. (2018). https://pubmed.ncbi.nlm.nih.gov/29164513/ DOI: 10.1007/s12011-017-1203-z
    Complete structured claim and evidence

  2. Plasma chromium increased with longer parenteral-nutrition exposure even when the trace-mineral supplement contained no chromium.

    Chromium → Circulating chromium concentration source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    evidence_span
    {"source_cache": "artifacts/chromium-research/39898458.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1776af33c0e684df33140b02e64d6cb2b4fa727cc167e6b17662e0f4c74275c7", "start_char": 0, "end_char": 1530, "text_sha256": "1776af33c0e684df33140b02e64d6cb2b4fa727cc167e6b17662e0f4c74275c7"}
    experimental_model
    Prospective observational study; 97 very-low-birthweight infants
    exposure
    Parenteral nutrition without added chromium from day 1; plasma days 15/30 and urine day 30
    limitations
    No added chromium does not mean zero exposure because components can contain chromium. Observational biomarker findings do not establish adequacy thresholds or universal neonatal dosing guidance.
    nutrient_topic
    Chromium research collection; topical membership is not evidence of a direct dietary effect. · Chromium
    organism
    Human premature infants
    plain_language
    The infants were still exposed to chromium through the nutrition system.
    primary_references
    [chromium-p39898458] Chromium-free parenteral nutrition and its effects on chromium levels in very low birth weight infants. (2025). https://pubmed.ncbi.nlm.nih.gov/39898458/ DOI: 10.20960/nh.05609
    tissue_or_cell_type
    Plasma and urine during neonatal nutrition
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Chromium: transport, insulin signaling, nutrient interactions and essentiality debate (2026-09-17) · lines 926–937

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Prospective observational study; 97 very-low-birthweight infants · source_derived_draft · unverified_draft

    ### chromium-neonatal-pn-exposure Plasma chromium increased with longer parenteral-nutrition exposure even when the trace-mineral supplement contained no chromium. Condition category: biomarker_context nutrient_topic: Chromium research collection; topical membership is not evidence of a direct dietary effect. plain_language: The infants were still exposed to chromium through the nutrition system. organism: Human premature infants tissue_or_cell_type: Plasma and urine during neonatal nutrition experimental_model: Prospective observational study; 97 very-low-birthweight infants limitations: No added chromium does not mean zero exposure because components can contain chromium. Observational biomarker findings do not establish adequacy thresholds or universal neonatal dosing guidance. exposure: Parenteral nutrition without added chromium from day 1; plasma days 15/30 and urine day 30 evidence_span: {"source_cache": "artifacts/chromium-research/39898458.abstract.txt", "locator": "Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "1776af33c0e684df33140b02e64d6cb2b4fa727cc167e6b17662e0f4c74275c7", "start_char": 0, "end_char": 1530, "text_sha256": "1776af33c0e684df33140b02e64d6cb2b4fa727cc167e6b17662e0f4c74275c7"} [chromium-p39898458] Chromium-free parenteral nutrition and its effects on chromium levels in very low birth weight infants. (2025). https://pubmed.ncbi.nlm.nih.gov/39898458/ DOI: 10.20960/nh.05609
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards