{"id":"ac9aad5f-8be1-5fe5-aa7a-09d471a757e4","stable_key":"4d8e4781-3878-5818-8d0a-7dbd6e024555:chromium-neonatal-marker-outcome-null","predicate":"no_detected_association_with","statement":"The neonatal study found no relation of measured plasma or urinary chromium to its assessed laboratory parameters or morbidity.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"e1351d65-daad-582a-af85-18260be3085a","mechanism_event_label":"The measured chromium differences were not linked to the reported clinical outcomes.","subject":{"id":"2de8ae1c-5a5b-50f2-85af-302f77368c37","slug":"circulating-chromium-concentration","display_name":"Circulating chromium concentration","entity_type_key":"cellular_process"},"object":{"id":"61b811c8-ada2-56b8-8f5d-337f3605b6dc","slug":"neonatal-morbidity","display_name":"Neonatal morbidity measurements","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e1351d65-daad-582a-af85-18260be3085a","stable_key":"4d8e4781-3878-5818-8d0a-7dbd6e024555:chromium-neonatal-marker-outcome-null-event","event_type":"observed_intervention","label":"The measured chromium differences were not linked to the reported clinical outcomes.","description":"The neonatal study found no relation of measured plasma or urinary chromium to its assessed laboratory parameters or morbidity.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1772161b-6891-5d30-a5bb-3c7616208b84","slug":"urinary-chromium-excretion","display_name":"Urinary chromium excretion","entity_type_key":"cellular_process"},"role":"measured_marker","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2de8ae1c-5a5b-50f2-85af-302f77368c37","slug":"circulating-chromium-concentration","display_name":"Circulating chromium concentration","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"61b811c8-ada2-56b8-8f5d-337f3605b6dc","slug":"neonatal-morbidity","display_name":"Neonatal morbidity measurements","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/chromium-research/39898458.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"1776af33c0e684df33140b02e64d6cb2b4fa727cc167e6b17662e0f4c74275c7\", \"start_char\": 0, \"end_char\": 1530, \"text_sha256\": \"1776af33c0e684df33140b02e64d6cb2b4fa727cc167e6b17662e0f4c74275c7\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Prospective observational study; 97 very-low-birthweight infants","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Parenteral nutrition without added chromium from day 1; plasma days 15/30 and urine day 30","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No added chromium does not mean zero exposure because components can contain chromium. 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(2025). https://pubmed.ncbi.nlm.nih.gov/39898458/ DOI: 10.20960/nh.05609","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma and urine during neonatal nutrition","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"5cd7e342-9c6e-5c82-9f0f-b1524885dded","evidence_kind":"source_excerpt","locator":"Lines 939-950","start_line":939,"end_line":950,"excerpt":"### chromium-neonatal-marker-outcome-null\nThe neonatal study found no relation of measured plasma or urinary chromium to its assessed laboratory parameters or morbidity.\nCondition category: biomarker_context\nnutrient_topic: Chromium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The measured chromium differences were not linked to the reported clinical outcomes.\norganism: Human premature infants\ntissue_or_cell_type: Plasma and urine during neonatal nutrition\nexperimental_model: Prospective observational study; 97 very-low-birthweight infants\nlimitations: No added chromium does not mean zero exposure because components can contain chromium. Observational biomarker findings do not establish adequacy thresholds or universal neonatal dosing guidance.\nexposure: Parenteral nutrition without added chromium from day 1; plasma days 15/30 and urine day 30\nevidence_span: {\"source_cache\": \"artifacts/chromium-research/39898458.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"1776af33c0e684df33140b02e64d6cb2b4fa727cc167e6b17662e0f4c74275c7\", \"start_char\": 0, \"end_char\": 1530, \"text_sha256\": \"1776af33c0e684df33140b02e64d6cb2b4fa727cc167e6b17662e0f4c74275c7\"}\n[chromium-p39898458] Chromium-free parenteral nutrition and its effects on chromium levels in very low birth weight infants. 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