{"id":"03ad92a5-1d99-5fc8-b565-a23089bbd266","stable_key":"4d8e4781-3878-5818-8d0a-7dbd6e024555:chromium-neonatal-pn-exposure","predicate":"unintentional_exposure_associated_with","statement":"Plasma chromium increased with longer parenteral-nutrition exposure even when the trace-mineral supplement contained no chromium.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"3fabdfd2-9847-598c-8e13-ff70f9844fea","mechanism_event_label":"The infants were still exposed to chromium through the nutrition system.","subject":{"id":"1d98d864-31cb-5d4f-a587-2b0eb692faa0","slug":"chromium","display_name":"Chromium","entity_type_key":"nutrient_element"},"object":{"id":"2de8ae1c-5a5b-50f2-85af-302f77368c37","slug":"circulating-chromium-concentration","display_name":"Circulating chromium concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3fabdfd2-9847-598c-8e13-ff70f9844fea","stable_key":"4d8e4781-3878-5818-8d0a-7dbd6e024555:chromium-neonatal-pn-exposure-event","event_type":"observed_intervention","label":"The infants were still exposed to chromium through the nutrition system.","description":"Plasma chromium increased with longer parenteral-nutrition exposure even when the trace-mineral supplement contained no chromium.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1d98d864-31cb-5d4f-a587-2b0eb692faa0","slug":"chromium","display_name":"Chromium","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2de8ae1c-5a5b-50f2-85af-302f77368c37","slug":"circulating-chromium-concentration","display_name":"Circulating chromium concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/chromium-research/39898458.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"1776af33c0e684df33140b02e64d6cb2b4fa727cc167e6b17662e0f4c74275c7\", \"start_char\": 0, \"end_char\": 1530, \"text_sha256\": \"1776af33c0e684df33140b02e64d6cb2b4fa727cc167e6b17662e0f4c74275c7\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Prospective observational study; 97 very-low-birthweight infants","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Parenteral nutrition without added chromium from day 1; plasma days 15/30 and urine day 30","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No added chromium does not mean zero exposure because components can contain chromium. Observational biomarker findings do not establish adequacy thresholds or universal neonatal dosing guidance.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Chromium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"chromium","display_name":"Chromium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human premature infants","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The infants were still exposed to chromium through the nutrition system.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[chromium-p39898458] Chromium-free parenteral nutrition and its effects on chromium levels in very low birth weight infants. (2025). https://pubmed.ncbi.nlm.nih.gov/39898458/ DOI: 10.20960/nh.05609","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma and urine during neonatal nutrition","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"d93f6929-d88c-5ae3-a399-d44a9c0b4f23","evidence_kind":"source_excerpt","locator":"Lines 926-937","start_line":926,"end_line":937,"excerpt":"### chromium-neonatal-pn-exposure\nPlasma chromium increased with longer parenteral-nutrition exposure even when the trace-mineral supplement contained no chromium.\nCondition category: biomarker_context\nnutrient_topic: Chromium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The infants were still exposed to chromium through the nutrition system.\norganism: Human premature infants\ntissue_or_cell_type: Plasma and urine during neonatal nutrition\nexperimental_model: Prospective observational study; 97 very-low-birthweight infants\nlimitations: No added chromium does not mean zero exposure because components can contain chromium. Observational biomarker findings do not establish adequacy thresholds or universal neonatal dosing guidance.\nexposure: Parenteral nutrition without added chromium from day 1; plasma days 15/30 and urine day 30\nevidence_span: {\"source_cache\": \"artifacts/chromium-research/39898458.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"1776af33c0e684df33140b02e64d6cb2b4fa727cc167e6b17662e0f4c74275c7\", \"start_char\": 0, \"end_char\": 1530, \"text_sha256\": \"1776af33c0e684df33140b02e64d6cb2b4fa727cc167e6b17662e0f4c74275c7\"}\n[chromium-p39898458] Chromium-free parenteral nutrition and its effects on chromium levels in very low birth weight infants. (2025). https://pubmed.ncbi.nlm.nih.gov/39898458/ DOI: 10.20960/nh.05609","model_system":"Prospective observational study; 97 very-low-birthweight infants","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [chromium-p39898458] Chromium-free parenteral nutrition and its effects on chromium levels in very low birth weight infants. (2025). https://pubmed.ncbi.nlm.nih.gov/39898458/ DOI: 10.20960/nh.05609","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"fa96342a-ca01-5425-98d9-d50e29bf0abd","stable_key":"import-4d8e4781-3878-5818-8d0a-7dbd6e024555","title":"Chromium: transport, insulin signaling, nutrient interactions and essentiality debate (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"6cae22f9104c6de041b25c23b0fd2884cc57707ac0c9a87c20b0e665d16de5ab","revision_id":"22893798-8329-5295-9c9d-82169032fc79","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}