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The direction changed with background iron; do not extrapolate a universal nutrient antagonism or human dose ratio.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Chromium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"chromium","display_name":"Chromium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Female Wistar rats","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Excess iron changed chromium distribution under these rat feeding conditions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[chromium-p29164513] The Combined Effects of Iron Excess in the Diet and Chromium(III) Supplementation on the Iron and Chromium Status in Female Rats. (2018). https://pubmed.ncbi.nlm.nih.gov/29164513/ DOI: 10.1007/s12011-017-1203-z","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Serum, liver and kidney metals","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"3650931a-f30b-57e6-a8bb-4cf7544897b7","evidence_kind":"source_excerpt","locator":"Lines 510-521","start_line":510,"end_line":521,"excerpt":"### chromium-iron-excess-chromium\nHigh dietary iron reduced serum, liver and kidney chromium concentrations in the study.\nCondition category: normal\nnutrient_topic: Chromium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Excess iron changed chromium distribution under these rat feeding conditions.\norganism: Female Wistar rats\ntissue_or_cell_type: Serum, liver and kidney metals\nexperimental_model: Factorial six-group iron-excess/chromium feeding experiment\nlimitations: High-dose animal study. The direction changed with background iron; do not extrapolate a universal nutrient antagonism or human dose ratio.\nexposure: Iron 45 versus 180 mg/kg diet; chromium propionate 1, 50 or 500 mg Cr/kg diet; six animals/group\nevidence_span: {\"source_cache\": \"artifacts/chromium-research/29164513.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"4d99145cb86f4110fd0087f9162fa057d87b445b9bc6a60c6467bb310f5e300b\", \"start_char\": 0, \"end_char\": 2450, \"text_sha256\": \"4d99145cb86f4110fd0087f9162fa057d87b445b9bc6a60c6467bb310f5e300b\"}\n[chromium-p29164513] The Combined Effects of Iron Excess in the Diet and Chromium(III) Supplementation on the Iron and Chromium Status in Female Rats. 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