Component

Human CAT1-mediated arginine uptake

Study-scoped entity; inspect species, exposure and experimental limitations on each claim.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. ADMA produced a competitive inhibition pattern for CAT1-mediated arginine uptake.

    Asymmetric dimethylarginine / ADMA → Human CAT1-mediated arginine uptake source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Full-text methods/results/discussion, Europe PMC PMC9217908.
    experimental_model
    HEK cells expressing human CAT1, compared with vector controls; radiolabeled substrate uptake.
    limitations
    Transport competition is distinct from direct NOS inhibition.
    nutrient_topic
    L-Arginine collection; tissue, species, dose and formulation distinctions retained. · L-Arginine
    plain_language
    An endogenous arginine derivative can compete at the entry step.
    primary_references
    Screening of commonly prescribed drugs for effects on the CAT1-mediated transport of L-arginine and arginine derivatives. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35377022/ · DOI 10.1007/s00726-022-03156-2

    L-Arginine: transport, metabolic branches, nutrient interactions, availability and discovery questions (2026-09-18) · lines 30–36

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · HEK cells expressing human CAT1, compared with vector controls; radiolabeled substrate uptake. · source_derived_draft · unverified_draft

    ## arg-adma-transport An endogenous arginine derivative can compete at the entry step. ADMA produced a competitive inhibition pattern for CAT1-mediated arginine uptake. Model: HEK cells expressing human CAT1, compared with vector controls; radiolabeled substrate uptake. Limitations: Transport competition is distinct from direct NOS inhibition. Evidence access: Full-text methods/results/discussion, Europe PMC PMC9217908. Screening of commonly prescribed drugs for effects on the CAT1-mediated transport of L-arginine and arginine derivatives. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35377022/ · DOI 10.1007/s00726-022-03156-2
    Complete structured claim and evidence

  2. Homoarginine produced a competitive inhibition pattern for CAT1-mediated arginine uptake.

    Homoarginine → Human CAT1-mediated arginine uptake source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Full-text methods/results/discussion, Europe PMC PMC9217908.
    experimental_model
    HEK cells expressing human CAT1, compared with vector controls; radiolabeled substrate uptake.
    limitations
    No clinical benefit or harm follows from the assay alone.
    nutrient_topic
    L-Arginine collection; tissue, species, dose and formulation distinctions retained. · L-Arginine
    plain_language
    A related amino acid shares transport machinery.
    primary_references
    Screening of commonly prescribed drugs for effects on the CAT1-mediated transport of L-arginine and arginine derivatives. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35377022/ · DOI 10.1007/s00726-022-03156-2

    L-Arginine: transport, metabolic branches, nutrient interactions, availability and discovery questions (2026-09-18) · lines 38–44

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · HEK cells expressing human CAT1, compared with vector controls; radiolabeled substrate uptake. · source_derived_draft · unverified_draft

    ## arg-homoarg-transport A related amino acid shares transport machinery. Homoarginine produced a competitive inhibition pattern for CAT1-mediated arginine uptake. Model: HEK cells expressing human CAT1, compared with vector controls; radiolabeled substrate uptake. Limitations: No clinical benefit or harm follows from the assay alone. Evidence access: Full-text methods/results/discussion, Europe PMC PMC9217908. Screening of commonly prescribed drugs for effects on the CAT1-mediated transport of L-arginine and arginine derivatives. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35377022/ · DOI 10.1007/s00726-022-03156-2
    Complete structured claim and evidence

  3. Verapamil inhibited CAT1 arginine uptake with IC50 85.3 micromolar and an uncompetitive pattern.

    Verapamil → Human CAT1-mediated arginine uptake source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Full-text methods/results/discussion, Europe PMC PMC9217908.
    experimental_model
    HEK cells expressing human CAT1, compared with vector controls; radiolabeled substrate uptake.
    limitations
    Far above free therapeutic plasma exposure; the authors considered a significant clinical transport interaction unlikely.
    nutrient_topic
    L-Arginine collection; tissue, species, dose and formulation distinctions retained. · L-Arginine
    plain_language
    A laboratory drug effect acts at the transport step.
    primary_references
    Screening of commonly prescribed drugs for effects on the CAT1-mediated transport of L-arginine and arginine derivatives. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35377022/ · DOI 10.1007/s00726-022-03156-2

    L-Arginine: transport, metabolic branches, nutrient interactions, availability and discovery questions (2026-09-18) · lines 46–52

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · HEK cells expressing human CAT1, compared with vector controls; radiolabeled substrate uptake. · source_derived_draft · unverified_draft

    ## arg-verapamil A laboratory drug effect acts at the transport step. Verapamil inhibited CAT1 arginine uptake with IC50 85.3 micromolar and an uncompetitive pattern. Model: HEK cells expressing human CAT1, compared with vector controls; radiolabeled substrate uptake. Limitations: Far above free therapeutic plasma exposure; the authors considered a significant clinical transport interaction unlikely. Evidence access: Full-text methods/results/discussion, Europe PMC PMC9217908. Screening of commonly prescribed drugs for effects on the CAT1-mediated transport of L-arginine and arginine derivatives. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35377022/ · DOI 10.1007/s00726-022-03156-2
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. CAT1 expression supported measurable uptake of arginine in the transporter assay.

    CAT1 / SLC7A1 → L-Arginine source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Full-text methods/results/discussion, Europe PMC PMC9217908.
    experimental_model
    HEK cells expressing human CAT1, compared with vector controls; radiolabeled substrate uptake.
    limitations
    An expression system does not measure every tissue flux.
    nutrient_topic
    L-Arginine collection; tissue, species, dose and formulation distinctions retained. · L-Arginine
    plain_language
    A membrane transporter controls entry into the cell.
    primary_references
    Screening of commonly prescribed drugs for effects on the CAT1-mediated transport of L-arginine and arginine derivatives. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35377022/ · DOI 10.1007/s00726-022-03156-2
    transport_effect
    raises Expression supported measurable uptake of arginine.
    transport_pool
    the expressing cell Expression supported measurable uptake of arginine.

    L-Arginine: transport, metabolic branches, nutrient interactions, availability and discovery questions (2026-09-18) · lines 22–28

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · HEK cells expressing human CAT1, compared with vector controls; radiolabeled substrate uptake. · source_derived_draft · unverified_draft

    ## arg-cat1 A membrane transporter controls entry into the cell. CAT1 expression supported measurable uptake of arginine in the transporter assay. Model: HEK cells expressing human CAT1, compared with vector controls; radiolabeled substrate uptake. Limitations: An expression system does not measure every tissue flux. Evidence access: Full-text methods/results/discussion, Europe PMC PMC9217908. Screening of commonly prescribed drugs for effects on the CAT1-mediated transport of L-arginine and arginine derivatives. · 2022 · https://pubmed.ncbi.nlm.nih.gov/35377022/ · DOI 10.1007/s00726-022-03156-2
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards