Component

Broccoli sprout preparation, composition specified per study

Broccoli sprout preparation, composition specified per study. Species, exposure and limitations are retained in each linked claim.

10 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Urinary acrolein-derived conjugate excretion increased by 23%.

    Broccoli sprout preparation, composition specified per study → Urinary acrolein-derived mercapturic acid source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/sulforaphane-research/24913818.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dabcc8a48260f668232ae3ab528fbf08e7b8b814ad9959d709fcd4702bbda7dd", "start_char": 0, "end_char": 1710, "text_sha256": "dabcc8a48260f668232ae3ab528fbf08e7b8b814ad9959d709fcd4702bbda7dd"}
    experimental_model
    Randomized placebo-controlled beverage trial
    exposure
    600 micromol glucoraphanin plus 40 micromol sulforaphane daily for 12 weeks
    limitations
    Urinary conjugate excretion is not proof of reduced cancer incidence, removal of every toxin or a clinical detoxification indication.
    nutrient_topic
    Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. · Sulforaphane / SFN, stereochemistry specified per study
    organism
    Human, 291 recruited adults in Qidong
    plain_language
    The result extended to a second measured pollutant.
    primary_references
    [sulforaphane-p24913818] Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China. (2014). https://pubmed.ncbi.nlm.nih.gov/24913818/ DOI: 10.1158/1940-6207.capr-14-0103
    tissue_or_cell_type
    Urinary pollutant mercapturates

    Sulforaphane: formation, electrophile sensing and nutrient connections (2026-09-17) · lines 1061–1072

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized placebo-controlled beverage trial · source_derived_draft · unverified_draft

    ### sulforaphane-acrolein-excretion Urinary acrolein-derived conjugate excretion increased by 23%. Condition category: normal nutrient_topic: Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. plain_language: The result extended to a second measured pollutant. organism: Human, 291 recruited adults in Qidong tissue_or_cell_type: Urinary pollutant mercapturates experimental_model: Randomized placebo-controlled beverage trial limitations: Urinary conjugate excretion is not proof of reduced cancer incidence, removal of every toxin or a clinical detoxification indication. exposure: 600 micromol glucoraphanin plus 40 micromol sulforaphane daily for 12 weeks evidence_span: {"source_cache": "artifacts/sulforaphane-research/24913818.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dabcc8a48260f668232ae3ab528fbf08e7b8b814ad9959d709fcd4702bbda7dd", "start_char": 0, "end_char": 1710, "text_sha256": "dabcc8a48260f668232ae3ab528fbf08e7b8b814ad9959d709fcd4702bbda7dd"} [sulforaphane-p24913818] Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China. (2014). https://pubmed.ncbi.nlm.nih.gov/24913818/ DOI: 10.1158/1940-6207.capr-14-0103
    Complete structured claim and evidence

  2. The intervention increased urinary benzene-derived conjugate excretion by 61% compared with placebo.

    Broccoli sprout preparation, composition specified per study → Urinary benzene-derived mercapturic acid source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/sulforaphane-research/24913818.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dabcc8a48260f668232ae3ab528fbf08e7b8b814ad9959d709fcd4702bbda7dd", "start_char": 0, "end_char": 1710, "text_sha256": "dabcc8a48260f668232ae3ab528fbf08e7b8b814ad9959d709fcd4702bbda7dd"}
    experimental_model
    Randomized placebo-controlled beverage trial
    exposure
    600 micromol glucoraphanin plus 40 micromol sulforaphane daily for 12 weeks
    limitations
    Urinary conjugate excretion is not proof of reduced cancer incidence, removal of every toxin or a clinical detoxification indication.
    nutrient_topic
    Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. · Sulforaphane / SFN, stereochemistry specified per study
    organism
    Human, 291 recruited adults in Qidong
    plain_language
    A specific exposure-processing marker increased.
    primary_references
    [sulforaphane-p24913818] Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China. (2014). https://pubmed.ncbi.nlm.nih.gov/24913818/ DOI: 10.1158/1940-6207.capr-14-0103
    tissue_or_cell_type
    Urinary pollutant mercapturates

    Sulforaphane: formation, electrophile sensing and nutrient connections (2026-09-17) · lines 1048–1059

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized placebo-controlled beverage trial · source_derived_draft · unverified_draft

    ### sulforaphane-benzene-excretion The intervention increased urinary benzene-derived conjugate excretion by 61% compared with placebo. Condition category: normal nutrient_topic: Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. plain_language: A specific exposure-processing marker increased. organism: Human, 291 recruited adults in Qidong tissue_or_cell_type: Urinary pollutant mercapturates experimental_model: Randomized placebo-controlled beverage trial limitations: Urinary conjugate excretion is not proof of reduced cancer incidence, removal of every toxin or a clinical detoxification indication. exposure: 600 micromol glucoraphanin plus 40 micromol sulforaphane daily for 12 weeks evidence_span: {"source_cache": "artifacts/sulforaphane-research/24913818.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dabcc8a48260f668232ae3ab528fbf08e7b8b814ad9959d709fcd4702bbda7dd", "start_char": 0, "end_char": 1710, "text_sha256": "dabcc8a48260f668232ae3ab528fbf08e7b8b814ad9959d709fcd4702bbda7dd"} [sulforaphane-p24913818] Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China. (2014). https://pubmed.ncbi.nlm.nih.gov/24913818/ DOI: 10.1158/1940-6207.capr-14-0103
    Complete structured claim and evidence

  3. Crotonaldehyde-derived conjugate excretion did not show the intervention increase observed for benzene and acrolein.

    Broccoli sprout preparation, composition specified per study → Urinary crotonaldehyde-derived mercapturic acid source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/sulforaphane-research/24913818.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dabcc8a48260f668232ae3ab528fbf08e7b8b814ad9959d709fcd4702bbda7dd", "start_char": 0, "end_char": 1710, "text_sha256": "dabcc8a48260f668232ae3ab528fbf08e7b8b814ad9959d709fcd4702bbda7dd"}
    experimental_model
    Randomized placebo-controlled beverage trial
    exposure
    600 micromol glucoraphanin plus 40 micromol sulforaphane daily for 12 weeks
    limitations
    Urinary conjugate excretion is not proof of reduced cancer incidence, removal of every toxin or a clinical detoxification indication.
    nutrient_topic
    Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. · Sulforaphane / SFN, stereochemistry specified per study
    organism
    Human, 291 recruited adults in Qidong
    plain_language
    The response was selective rather than a universal detoxification boost.
    primary_references
    [sulforaphane-p24913818] Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China. (2014). https://pubmed.ncbi.nlm.nih.gov/24913818/ DOI: 10.1158/1940-6207.capr-14-0103
    tissue_or_cell_type
    Urinary pollutant mercapturates

    Sulforaphane: formation, electrophile sensing and nutrient connections (2026-09-17) · lines 1074–1085

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized placebo-controlled beverage trial · source_derived_draft · unverified_draft

    ### sulforaphane-crotonaldehyde-null Crotonaldehyde-derived conjugate excretion did not show the intervention increase observed for benzene and acrolein. Condition category: normal nutrient_topic: Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. plain_language: The response was selective rather than a universal detoxification boost. organism: Human, 291 recruited adults in Qidong tissue_or_cell_type: Urinary pollutant mercapturates experimental_model: Randomized placebo-controlled beverage trial limitations: Urinary conjugate excretion is not proof of reduced cancer incidence, removal of every toxin or a clinical detoxification indication. exposure: 600 micromol glucoraphanin plus 40 micromol sulforaphane daily for 12 weeks evidence_span: {"source_cache": "artifacts/sulforaphane-research/24913818.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dabcc8a48260f668232ae3ab528fbf08e7b8b814ad9959d709fcd4702bbda7dd", "start_char": 0, "end_char": 1710, "text_sha256": "dabcc8a48260f668232ae3ab528fbf08e7b8b814ad9959d709fcd4702bbda7dd"} [sulforaphane-p24913818] Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China. (2014). https://pubmed.ncbi.nlm.nih.gov/24913818/ DOI: 10.1158/1940-6207.capr-14-0103
    Complete structured claim and evidence

  4. Concentrated broccoli sprout extract lowered fasting glucose in obese patients with dysregulated type 2 diabetes in the reported subgroup.

    Broccoli sprout preparation, composition specified per study → Fasting plasma glucose source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/sulforaphane-research/28615356.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "65f64f5fa5e84a03d3ba4b647ce94a815fd3bd345486b726e7a54f1a813cab0e", "start_char": 0, "end_char": 1106, "text_sha256": "65f64f5fa5e84a03d3ba4b647ce94a815fd3bd345486b726e7a54f1a813cab0e"}
    experimental_model
    Network-guided preclinical work with a human intervention
    exposure
    Concentrated broccoli sprout extract; obese dysregulated-diabetes subgroup
    limitations
    Model-based mechanism and clinical subgroup outcomes are distinct; no equivalence to metformin in patients is claimed.
    nutrient_topic
    Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. · Sulforaphane / SFN, stereochemistry specified per study
    organism
    Hepatic cell/animal models and humans with type 2 diabetes
    plain_language
    The clinical response depended on the studied metabolic population.
    primary_references
    [sulforaphane-p28615356] Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes. (2017). https://pubmed.ncbi.nlm.nih.gov/28615356/ DOI: 10.1126/scitranslmed.aah4477
    tissue_or_cell_type
    Glucose production and clinical glucose control

    Sulforaphane: formation, electrophile sensing and nutrient connections (2026-09-17) · lines 1152–1163

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Network-guided preclinical work with a human intervention · source_derived_draft · unverified_draft

    ### sulforaphane-diabetes-glucose Concentrated broccoli sprout extract lowered fasting glucose in obese patients with dysregulated type 2 diabetes in the reported subgroup. Condition category: normal nutrient_topic: Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. plain_language: The clinical response depended on the studied metabolic population. organism: Hepatic cell/animal models and humans with type 2 diabetes tissue_or_cell_type: Glucose production and clinical glucose control experimental_model: Network-guided preclinical work with a human intervention limitations: Model-based mechanism and clinical subgroup outcomes are distinct; no equivalence to metformin in patients is claimed. exposure: Concentrated broccoli sprout extract; obese dysregulated-diabetes subgroup evidence_span: {"source_cache": "artifacts/sulforaphane-research/28615356.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "65f64f5fa5e84a03d3ba4b647ce94a815fd3bd345486b726e7a54f1a813cab0e", "start_char": 0, "end_char": 1106, "text_sha256": "65f64f5fa5e84a03d3ba4b647ce94a815fd3bd345486b726e7a54f1a813cab0e"} [sulforaphane-p28615356] Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes. (2017). https://pubmed.ncbi.nlm.nih.gov/28615356/ DOI: 10.1126/scitranslmed.aah4477
    Complete structured claim and evidence

  5. HbA1c decreased in the reported obese dysregulated-diabetes subgroup.

    Broccoli sprout preparation, composition specified per study → Glycated hemoglobin / HbA1c concentration source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/sulforaphane-research/28615356.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "65f64f5fa5e84a03d3ba4b647ce94a815fd3bd345486b726e7a54f1a813cab0e", "start_char": 0, "end_char": 1106, "text_sha256": "65f64f5fa5e84a03d3ba4b647ce94a815fd3bd345486b726e7a54f1a813cab0e"}
    experimental_model
    Network-guided preclinical work with a human intervention
    exposure
    Concentrated broccoli sprout extract; obese dysregulated-diabetes subgroup
    limitations
    Model-based mechanism and clinical subgroup outcomes are distinct; no equivalence to metformin in patients is claimed.
    nutrient_topic
    Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. · Sulforaphane / SFN, stereochemistry specified per study
    organism
    Hepatic cell/animal models and humans with type 2 diabetes
    plain_language
    A longer-term glucose marker also changed in that subgroup.
    primary_references
    [sulforaphane-p28615356] Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes. (2017). https://pubmed.ncbi.nlm.nih.gov/28615356/ DOI: 10.1126/scitranslmed.aah4477
    tissue_or_cell_type
    Glucose production and clinical glucose control

    Sulforaphane: formation, electrophile sensing and nutrient connections (2026-09-17) · lines 1165–1176

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Network-guided preclinical work with a human intervention · source_derived_draft · unverified_draft

    ### sulforaphane-diabetes-hba1c HbA1c decreased in the reported obese dysregulated-diabetes subgroup. Condition category: normal nutrient_topic: Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. plain_language: A longer-term glucose marker also changed in that subgroup. organism: Hepatic cell/animal models and humans with type 2 diabetes tissue_or_cell_type: Glucose production and clinical glucose control experimental_model: Network-guided preclinical work with a human intervention limitations: Model-based mechanism and clinical subgroup outcomes are distinct; no equivalence to metformin in patients is claimed. exposure: Concentrated broccoli sprout extract; obese dysregulated-diabetes subgroup evidence_span: {"source_cache": "artifacts/sulforaphane-research/28615356.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "65f64f5fa5e84a03d3ba4b647ce94a815fd3bd345486b726e7a54f1a813cab0e", "start_char": 0, "end_char": 1106, "text_sha256": "65f64f5fa5e84a03d3ba4b647ce94a815fd3bd345486b726e7a54f1a813cab0e"} [sulforaphane-p28615356] Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes. (2017). https://pubmed.ncbi.nlm.nih.gov/28615356/ DOI: 10.1126/scitranslmed.aah4477
    Complete structured claim and evidence

  6. Urea breath-test and stool-antigen measures declined during broccoli sprout treatment and returned toward baseline after discontinuation.

    Broccoli sprout preparation, composition specified per study → Urea breath test and stool H. pylori antigen source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/sulforaphane-research/19349290.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d4d4cc51db00f336baa1c258bae013de96d52dfd8c2433096358bba600e6fbbd", "start_char": 0, "end_char": 1793, "text_sha256": "d4d4cc51db00f336baa1c258bae013de96d52dfd8c2433096358bba600e6fbbd"}
    experimental_model
    Randomized sprout intervention with a separate knockout-mouse experiment
    exposure
    70 g/day broccoli sprouts containing 420 micromol precursor versus alfalfa for eight weeks
    limitations
    Whole-food intervention; reduced biomarkers did not establish durable eradication or replace antibiotic therapy.
    nutrient_topic
    Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. · Sulforaphane / SFN, stereochemistry specified per study
    organism
    Human, 48 H. pylori-infected participants; mouse study distinct
    plain_language
    The effect was temporary and was not proof of durable eradication.
    primary_references
    [sulforaphane-p19349290] Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans. (2009). https://pubmed.ncbi.nlm.nih.gov/19349290/ DOI: 10.1158/1940-6207.capr-08-0192
    tissue_or_cell_type
    Colonization and inflammation biomarkers

    Sulforaphane: formation, electrophile sensing and nutrient connections (2026-09-17) · lines 1308–1319

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized sprout intervention with a separate knockout-mouse experiment · source_derived_draft · unverified_draft

    ### sulforaphane-hpy-biomarkers Urea breath-test and stool-antigen measures declined during broccoli sprout treatment and returned toward baseline after discontinuation. Condition category: normal nutrient_topic: Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. plain_language: The effect was temporary and was not proof of durable eradication. organism: Human, 48 H. pylori-infected participants; mouse study distinct tissue_or_cell_type: Colonization and inflammation biomarkers experimental_model: Randomized sprout intervention with a separate knockout-mouse experiment limitations: Whole-food intervention; reduced biomarkers did not establish durable eradication or replace antibiotic therapy. exposure: 70 g/day broccoli sprouts containing 420 micromol precursor versus alfalfa for eight weeks evidence_span: {"source_cache": "artifacts/sulforaphane-research/19349290.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d4d4cc51db00f336baa1c258bae013de96d52dfd8c2433096358bba600e6fbbd", "start_char": 0, "end_char": 1793, "text_sha256": "d4d4cc51db00f336baa1c258bae013de96d52dfd8c2433096358bba600e6fbbd"} [sulforaphane-p19349290] Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans. (2009). https://pubmed.ncbi.nlm.nih.gov/19349290/ DOI: 10.1158/1940-6207.capr-08-0192
    Complete structured claim and evidence

  7. Serum pepsinogens I and II declined during the human intervention and recovered after it ended.

    Broccoli sprout preparation, composition specified per study → Serum pepsinogen I and II source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/sulforaphane-research/19349290.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d4d4cc51db00f336baa1c258bae013de96d52dfd8c2433096358bba600e6fbbd", "start_char": 0, "end_char": 1793, "text_sha256": "d4d4cc51db00f336baa1c258bae013de96d52dfd8c2433096358bba600e6fbbd"}
    experimental_model
    Randomized sprout intervention with a separate knockout-mouse experiment
    exposure
    70 g/day broccoli sprouts containing 420 micromol precursor versus alfalfa for eight weeks
    limitations
    Whole-food intervention; reduced biomarkers did not establish durable eradication or replace antibiotic therapy.
    nutrient_topic
    Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. · Sulforaphane / SFN, stereochemistry specified per study
    organism
    Human, 48 H. pylori-infected participants; mouse study distinct
    plain_language
    Inflammation-related markers changed alongside colonization markers.
    primary_references
    [sulforaphane-p19349290] Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans. (2009). https://pubmed.ncbi.nlm.nih.gov/19349290/ DOI: 10.1158/1940-6207.capr-08-0192
    tissue_or_cell_type
    Colonization and inflammation biomarkers

    Sulforaphane: formation, electrophile sensing and nutrient connections (2026-09-17) · lines 1321–1332

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized sprout intervention with a separate knockout-mouse experiment · source_derived_draft · unverified_draft

    ### sulforaphane-hpy-inflammation Serum pepsinogens I and II declined during the human intervention and recovered after it ended. Condition category: normal nutrient_topic: Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. plain_language: Inflammation-related markers changed alongside colonization markers. organism: Human, 48 H. pylori-infected participants; mouse study distinct tissue_or_cell_type: Colonization and inflammation biomarkers experimental_model: Randomized sprout intervention with a separate knockout-mouse experiment limitations: Whole-food intervention; reduced biomarkers did not establish durable eradication or replace antibiotic therapy. exposure: 70 g/day broccoli sprouts containing 420 micromol precursor versus alfalfa for eight weeks evidence_span: {"source_cache": "artifacts/sulforaphane-research/19349290.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d4d4cc51db00f336baa1c258bae013de96d52dfd8c2433096358bba600e6fbbd", "start_char": 0, "end_char": 1793, "text_sha256": "d4d4cc51db00f336baa1c258bae013de96d52dfd8c2433096358bba600e6fbbd"} [sulforaphane-p19349290] Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans. (2009). https://pubmed.ncbi.nlm.nih.gov/19349290/ DOI: 10.1158/1940-6207.capr-08-0192
    Complete structured claim and evidence

  8. Gastrointestinal side effects occurred; no severe adverse events were reported in the trial.

    Broccoli sprout preparation, composition specified per study → Gastrointestinal adverse events source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/sulforaphane-research/39929977.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "525674c523bafc5e583bea8f2402f9e6dcf792c93b5af0c0f19d3aee15393a92", "start_char": 0, "end_char": 1849, "text_sha256": "525674c523bafc5e583bea8f2402f9e6dcf792c93b5af0c0f19d3aee15393a92"}
    experimental_model
    Randomized double-blind placebo-controlled trial with exploratory microbiome analysis
    exposure
    Daily broccoli sprout extract for 12 weeks
    limitations
    Primary target was 0.3 mmol/L; subgroup and microbiome results were exploratory and need confirmation.
    nutrient_topic
    Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. · Sulforaphane / SFN, stereochemistry specified per study
    organism
    Human prediabetes; 35 extract and 39 placebo participants analyzed
    plain_language
    Tolerability and efficacy are separate outcomes.
    primary_references
    [sulforaphane-p39929977] Effect of broccoli sprout extract and baseline gut microbiota on fasting blood glucose in prediabetes: a randomized, placebo-controlled trial. (2025). https://pubmed.ncbi.nlm.nih.gov/39929977/ DOI: 10.1038/s41564-025-01932-w
    tissue_or_cell_type
    Fasting glucose and serum exposure

    Sulforaphane: formation, electrophile sensing and nutrient connections (2026-09-17) · lines 1204–1215

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized double-blind placebo-controlled trial with exploratory microbiome analysis · source_derived_draft · unverified_draft

    ### sulforaphane-prediabetes-gi Gastrointestinal side effects occurred; no severe adverse events were reported in the trial. Condition category: normal nutrient_topic: Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. plain_language: Tolerability and efficacy are separate outcomes. organism: Human prediabetes; 35 extract and 39 placebo participants analyzed tissue_or_cell_type: Fasting glucose and serum exposure experimental_model: Randomized double-blind placebo-controlled trial with exploratory microbiome analysis limitations: Primary target was 0.3 mmol/L; subgroup and microbiome results were exploratory and need confirmation. exposure: Daily broccoli sprout extract for 12 weeks evidence_span: {"source_cache": "artifacts/sulforaphane-research/39929977.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "525674c523bafc5e583bea8f2402f9e6dcf792c93b5af0c0f19d3aee15393a92", "start_char": 0, "end_char": 1849, "text_sha256": "525674c523bafc5e583bea8f2402f9e6dcf792c93b5af0c0f19d3aee15393a92"} [sulforaphane-p39929977] Effect of broccoli sprout extract and baseline gut microbiota on fasting blood glucose in prediabetes: a randomized, placebo-controlled trial. (2025). https://pubmed.ncbi.nlm.nih.gov/39929977/ DOI: 10.1038/s41564-025-01932-w
    Complete structured claim and evidence

  9. The mean glucose reduction versus placebo was 0.2 mmol/L (95% CI -0.44 to -0.01; P=0.04), below the prespecified 0.3 mmol/L target.

    Broccoli sprout preparation, composition specified per study → Fasting plasma glucose source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/sulforaphane-research/39929977.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "525674c523bafc5e583bea8f2402f9e6dcf792c93b5af0c0f19d3aee15393a92", "start_char": 0, "end_char": 1849, "text_sha256": "525674c523bafc5e583bea8f2402f9e6dcf792c93b5af0c0f19d3aee15393a92"}
    experimental_model
    Randomized double-blind placebo-controlled trial with exploratory microbiome analysis
    exposure
    Daily broccoli sprout extract for 12 weeks
    limitations
    Primary target was 0.3 mmol/L; subgroup and microbiome results were exploratory and need confirmation.
    nutrient_topic
    Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. · Sulforaphane / SFN, stereochemistry specified per study
    organism
    Human prediabetes; 35 extract and 39 placebo participants analyzed
    plain_language
    A small statistical signal did not meet the trial's planned target.
    primary_references
    [sulforaphane-p39929977] Effect of broccoli sprout extract and baseline gut microbiota on fasting blood glucose in prediabetes: a randomized, placebo-controlled trial. (2025). https://pubmed.ncbi.nlm.nih.gov/39929977/ DOI: 10.1038/s41564-025-01932-w
    tissue_or_cell_type
    Fasting glucose and serum exposure

    Sulforaphane: formation, electrophile sensing and nutrient connections (2026-09-17) · lines 1178–1189

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized double-blind placebo-controlled trial with exploratory microbiome analysis · source_derived_draft · unverified_draft

    ### sulforaphane-prediabetes-primary The mean glucose reduction versus placebo was 0.2 mmol/L (95% CI -0.44 to -0.01; P=0.04), below the prespecified 0.3 mmol/L target. Condition category: normal nutrient_topic: Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. plain_language: A small statistical signal did not meet the trial's planned target. organism: Human prediabetes; 35 extract and 39 placebo participants analyzed tissue_or_cell_type: Fasting glucose and serum exposure experimental_model: Randomized double-blind placebo-controlled trial with exploratory microbiome analysis limitations: Primary target was 0.3 mmol/L; subgroup and microbiome results were exploratory and need confirmation. exposure: Daily broccoli sprout extract for 12 weeks evidence_span: {"source_cache": "artifacts/sulforaphane-research/39929977.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "525674c523bafc5e583bea8f2402f9e6dcf792c93b5af0c0f19d3aee15393a92", "start_char": 0, "end_char": 1849, "text_sha256": "525674c523bafc5e583bea8f2402f9e6dcf792c93b5af0c0f19d3aee15393a92"} [sulforaphane-p39929977] Effect of broccoli sprout extract and baseline gut microbiota on fasting blood glucose in prediabetes: a randomized, placebo-controlled trial. (2025). https://pubmed.ncbi.nlm.nih.gov/39929977/ DOI: 10.1038/s41564-025-01932-w
    Complete structured claim and evidence

  10. TSH, free thyroxine, thyroglobulin and thyroid autoimmunity status were not affected in this 84-day analysis.

    Broccoli sprout preparation, composition specified per study → Thyroid autoimmunity markers, trial specified source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/sulforaphane-research/30735751.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0797bbf31c4a1fa8cf002b8752410e80a92e8a351c44273335bc52f19e66b2ea", "start_char": 0, "end_char": 1494, "text_sha256": "0797bbf31c4a1fa8cf002b8752410e80a92e8a351c44273335bc52f19e66b2ea"}
    experimental_model
    Thyroid safety analysis within a randomized beverage trial
    exposure
    Baseline and 84 days of glucoraphanin/sulforaphane-rich beverage
    limitations
    Subsample safety analysis; not all populations, iodine-deficient states, products, doses or lifelong exposure.
    nutrient_topic
    Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. · Sulforaphane / SFN, stereochemistry specified per study
    organism
    Human, 45 women
    plain_language
    This preparation showed no thyroid signal under the conditions tested; that is not universal thyroid safety proof.
    primary_references
    [sulforaphane-p30735751] Broccoli sprout beverage is safe for thyroid hormonal and autoimmune status: Results of a 12-week randomized trial. (2019). https://pubmed.ncbi.nlm.nih.gov/30735751/ DOI: 10.1016/j.fct.2019.02.004
    tissue_or_cell_type
    Serum thyroid hormones, thyroglobulin and autoimmunity

    Sulforaphane: formation, electrophile sensing and nutrient connections (2026-09-17) · lines 1217–1228

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Thyroid safety analysis within a randomized beverage trial · source_derived_draft · unverified_draft

    ### sulforaphane-thyroid-markers TSH, free thyroxine, thyroglobulin and thyroid autoimmunity status were not affected in this 84-day analysis. Condition category: normal nutrient_topic: Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. plain_language: This preparation showed no thyroid signal under the conditions tested; that is not universal thyroid safety proof. organism: Human, 45 women tissue_or_cell_type: Serum thyroid hormones, thyroglobulin and autoimmunity experimental_model: Thyroid safety analysis within a randomized beverage trial limitations: Subsample safety analysis; not all populations, iodine-deficient states, products, doses or lifelong exposure. exposure: Baseline and 84 days of glucoraphanin/sulforaphane-rich beverage evidence_span: {"source_cache": "artifacts/sulforaphane-research/30735751.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "0797bbf31c4a1fa8cf002b8752410e80a92e8a351c44273335bc52f19e66b2ea", "start_char": 0, "end_char": 1494, "text_sha256": "0797bbf31c4a1fa8cf002b8752410e80a92e8a351c44273335bc52f19e66b2ea"} [sulforaphane-p30735751] Broccoli sprout beverage is safe for thyroid hormonal and autoimmune status: Results of a 12-week randomized trial. (2019). https://pubmed.ncbi.nlm.nih.gov/30735751/ DOI: 10.1016/j.fct.2019.02.004
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards