{"id":"176c62a9-ff34-5803-9a8e-93264610e665","stable_key":"44eaeae5-557a-552b-8998-884f30462e2a:sulforaphane-thyroid-markers","predicate":"did_not_change","statement":"TSH, free thyroxine, thyroglobulin and thyroid autoimmunity status were not affected in this 84-day analysis.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"528d06c8-8675-5f06-8b99-b07e0aef6709","mechanism_event_label":"This preparation showed no thyroid signal under the conditions tested; that is not universal thyroid safety proof.","subject":{"id":"2586cbe4-fa07-5be1-8a37-8e48b3835c42","slug":"broccoli-sprout-preparation","display_name":"Broccoli sprout preparation, composition specified per study","entity_type_key":"chemical_species"},"object":{"id":"5ddb4b12-3564-5514-9e6a-cd8451d8fe6f","slug":"thyroid-autoimmunity-status","display_name":"Thyroid autoimmunity markers, trial specified","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"528d06c8-8675-5f06-8b99-b07e0aef6709","stable_key":"44eaeae5-557a-552b-8998-884f30462e2a:sulforaphane-thyroid-markers-event","event_type":"biochemical_relationship","label":"This preparation showed no thyroid signal under the conditions tested; that is not universal thyroid safety proof.","description":"TSH, free thyroxine, thyroglobulin and thyroid autoimmunity status were not affected in this 84-day analysis.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f2b25f38-ec94-57d0-a46d-dd0fee45f01e","slug":"thyroxine","display_name":"T4","entity_type_key":"small_molecule"},"role":"measured_hormone","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ab42f761-f2c0-52e6-876b-12df0d1d03d7","slug":"thyroglobulin","display_name":"Human thyroglobulin","entity_type_key":"protein"},"role":"measured_protein","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2586cbe4-fa07-5be1-8a37-8e48b3835c42","slug":"broccoli-sprout-preparation","display_name":"Broccoli sprout preparation, composition specified per study","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"5ddb4b12-3564-5514-9e6a-cd8451d8fe6f","slug":"thyroid-autoimmunity-status","display_name":"Thyroid autoimmunity markers, trial specified","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/sulforaphane-research/30735751.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0797bbf31c4a1fa8cf002b8752410e80a92e8a351c44273335bc52f19e66b2ea\", \"start_char\": 0, \"end_char\": 1494, \"text_sha256\": \"0797bbf31c4a1fa8cf002b8752410e80a92e8a351c44273335bc52f19e66b2ea\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Thyroid safety analysis within a randomized beverage trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Baseline and 84 days of glucoraphanin/sulforaphane-rich beverage","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Subsample safety analysis; not all populations, iodine-deficient states, products, doses or lifelong exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Sulforaphane research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"sulforaphane","display_name":"Sulforaphane / SFN, stereochemistry specified per study","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human, 45 women","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"This preparation showed no thyroid signal under the conditions tested; that is not universal thyroid safety proof.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[sulforaphane-p30735751] Broccoli sprout beverage is safe for thyroid hormonal and autoimmune status: Results of a 12-week randomized trial. (2019). https://pubmed.ncbi.nlm.nih.gov/30735751/ DOI: 10.1016/j.fct.2019.02.004","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Serum thyroid hormones, thyroglobulin and autoimmunity","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f5e5bd2e-8556-5241-9a8d-30e997d2857a","evidence_kind":"source_excerpt","locator":"Lines 1217-1228","start_line":1217,"end_line":1228,"excerpt":"### sulforaphane-thyroid-markers\nTSH, free thyroxine, thyroglobulin and thyroid autoimmunity status were not affected in this 84-day analysis.\nCondition category: normal\nnutrient_topic: Sulforaphane research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: This preparation showed no thyroid signal under the conditions tested; that is not universal thyroid safety proof.\norganism: Human, 45 women\ntissue_or_cell_type: Serum thyroid hormones, thyroglobulin and autoimmunity\nexperimental_model: Thyroid safety analysis within a randomized beverage trial\nlimitations: Subsample safety analysis; not all populations, iodine-deficient states, products, doses or lifelong exposure.\nexposure: Baseline and 84 days of glucoraphanin/sulforaphane-rich beverage\nevidence_span: {\"source_cache\": \"artifacts/sulforaphane-research/30735751.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0797bbf31c4a1fa8cf002b8752410e80a92e8a351c44273335bc52f19e66b2ea\", \"start_char\": 0, \"end_char\": 1494, \"text_sha256\": \"0797bbf31c4a1fa8cf002b8752410e80a92e8a351c44273335bc52f19e66b2ea\"}\n[sulforaphane-p30735751] Broccoli sprout beverage is safe for thyroid hormonal and autoimmune status: Results of a 12-week randomized trial. (2019). https://pubmed.ncbi.nlm.nih.gov/30735751/ DOI: 10.1016/j.fct.2019.02.004","model_system":"Thyroid safety analysis within a randomized beverage trial","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [sulforaphane-p30735751] Broccoli sprout beverage is safe for thyroid hormonal and autoimmune status: Results of a 12-week randomized trial. (2019). https://pubmed.ncbi.nlm.nih.gov/30735751/ DOI: 10.1016/j.fct.2019.02.004","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"a4bafbf7-f117-53c9-a6d7-8fb25e4aca72","stable_key":"import-44eaeae5-557a-552b-8998-884f30462e2a","title":"Sulforaphane: formation, electrophile sensing and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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