Component
Serum pepsinogen I and II
Serum pepsinogen I and II. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Serum pepsinogens I and II declined during the human intervention and recovered after it ended.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/sulforaphane-research/19349290.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d4d4cc51db00f336baa1c258bae013de96d52dfd8c2433096358bba600e6fbbd", "start_char": 0, "end_char": 1793, "text_sha256": "d4d4cc51db00f336baa1c258bae013de96d52dfd8c2433096358bba600e6fbbd"}
- experimental_model
- Randomized sprout intervention with a separate knockout-mouse experiment
- exposure
- 70 g/day broccoli sprouts containing 420 micromol precursor versus alfalfa for eight weeks
- limitations
- Whole-food intervention; reduced biomarkers did not establish durable eradication or replace antibiotic therapy.
- nutrient_topic
- Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. · Sulforaphane / SFN, stereochemistry specified per study
- organism
- Human, 48 H. pylori-infected participants; mouse study distinct
- plain_language
- Inflammation-related markers changed alongside colonization markers.
- primary_references
- [sulforaphane-p19349290] Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans. (2009). https://pubmed.ncbi.nlm.nih.gov/19349290/ DOI: 10.1158/1940-6207.capr-08-0192
- tissue_or_cell_type
- Colonization and inflammation biomarkers
Sulforaphane: formation, electrophile sensing and nutrient connections (2026-09-17) · lines 1321–1332
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized sprout intervention with a separate knockout-mouse experiment · source_derived_draft · unverified_draft
### sulforaphane-hpy-inflammation Serum pepsinogens I and II declined during the human intervention and recovered after it ended. Condition category: normal nutrient_topic: Sulforaphane research collection; topical membership is not evidence of a direct dietary effect. plain_language: Inflammation-related markers changed alongside colonization markers. organism: Human, 48 H. pylori-infected participants; mouse study distinct tissue_or_cell_type: Colonization and inflammation biomarkers experimental_model: Randomized sprout intervention with a separate knockout-mouse experiment limitations: Whole-food intervention; reduced biomarkers did not establish durable eradication or replace antibiotic therapy. exposure: 70 g/day broccoli sprouts containing 420 micromol precursor versus alfalfa for eight weeks evidence_span: {"source_cache": "artifacts/sulforaphane-research/19349290.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "d4d4cc51db00f336baa1c258bae013de96d52dfd8c2433096358bba600e6fbbd", "start_char": 0, "end_char": 1793, "text_sha256": "d4d4cc51db00f336baa1c258bae013de96d52dfd8c2433096358bba600e6fbbd"} [sulforaphane-p19349290] Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans. (2009). https://pubmed.ncbi.nlm.nih.gov/19349290/ DOI: 10.1158/1940-6207.capr-08-0192
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.