Component

Aged garlic extract in AGE at Heart 2016

Aged garlic extract in AGE at Heart 2016. Interpret through the linked study species, preparation, exposure and measured endpoint.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. The overall diastolic difference in AGE at Heart was not significant: -1.9 +/- 1.2 mmHg, P=0.12.

    Aged garlic extract in AGE at Heart 2016 → Diastolic blood pressure in the garlic trials source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text available; selected claim-relevant methods, results, tables/figures and limitations reviewed. Supplemental proteome and all secondary findings are not exhaustively extracted.
    experimental_contrast
    {"intervention": "Specified aged garlic extract", "comparator": "Placebo", "endpoint": "The overall diastolic difference in AGE at Heart was not significant: -1.9 +/- 1.2 mmHg, P=0.12.", "effect_direction": "no_detected_change", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
    experimental_model
    Same 12-week trial and analysis group.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    Preserve alongside the systolic result; not universal lack of BP effect.
    plain_language
    The overall diastolic difference in AGE at Heart was not significant: -1.9 +/- 1.2 mmHg, P=0.12.
    primary_references
    The effect of aged garlic extract on blood pressure and other cardiovascular risk factors in uncontrolled hypertensives: the AGE at Heart trial. | 2016 | DOI 10.2147/ibpc.s93335 | PMID 26869811 | https://pubmed.ncbi.nlm.nih.gov/26869811/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC4734812/ | https://doi.org/10.2147/ibpc.s93335
    source_locator
    Reviewed reference lines 89-89; exact primary location described in quoted passage where extracted.

    Allicin: detailed mechanisms of action (reviewed 5 October 2026) · lines 89–89

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Same 12-week trial and analysis group. · source_derived_draft · unverified_draft

    **Blood pressure.** AGE at Heart tested 1.2 g/day aged garlic extract containing 1.2 mg SAC for twelve weeks. Ninety-five participants completed the trial; seven were excluded for protocol deviations, leaving eighty-eight in the full analysis. Mean placebo-adjusted systolic change was about −5.0 ± 2.1 mmHg. The overall diastolic difference was not significant (−1.9 ± 1.2 mmHg, P=0.12). Larger reductions in retrospectively defined responders do not replace the overall comparison. This was an extract trial, not purified allicin or proof of sulfide mediation. Manufacturer involvement and the analysis exclusions limit interpretation. [Ried 2016](https://pmc.ncbi.nlm.nih.gov/articles/PMC4734812/)
    Complete structured claim and evidence

  2. AGE at Heart reported an approximately 5.0 +/- 2.1 mmHg placebo-adjusted systolic reduction in the full analysis group.

    Aged garlic extract in AGE at Heart 2016 → Systolic blood pressure source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text available; selected claim-relevant methods, results, tables/figures and limitations reviewed. Supplemental proteome and all secondary findings are not exhaustively extracted.
    experimental_contrast
    {"intervention": "Specified aged garlic extract", "comparator": "Placebo", "endpoint": "AGE at Heart reported an approximately 5.0 +/- 2.1 mmHg placebo-adjusted systolic reduction in the full analysis group.", "effect_direction": "decrease", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
    experimental_model
    1.2 g/day AGE containing 1.2 mg SAC, 12 weeks; 88 analyzed after seven completer exclusions.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    Not purified allicin; selected responders are not the overall randomized comparison; no established sulfide mediator.
    plain_language
    AGE at Heart reported an approximately 5.0 +/- 2.1 mmHg placebo-adjusted systolic reduction in the full analysis group.
    primary_references
    The effect of aged garlic extract on blood pressure and other cardiovascular risk factors in uncontrolled hypertensives: the AGE at Heart trial. | 2016 | DOI 10.2147/ibpc.s93335 | PMID 26869811 | https://pubmed.ncbi.nlm.nih.gov/26869811/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC4734812/ | https://doi.org/10.2147/ibpc.s93335
    source_locator
    Reviewed reference lines 89-89; exact primary location described in quoted passage where extracted.

    Allicin: detailed mechanisms of action (reviewed 5 October 2026) · lines 89–89

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · 1.2 g/day AGE containing 1.2 mg SAC, 12 weeks; 88 analyzed after seven completer exclusions. · source_derived_draft · unverified_draft

    **Blood pressure.** AGE at Heart tested 1.2 g/day aged garlic extract containing 1.2 mg SAC for twelve weeks. Ninety-five participants completed the trial; seven were excluded for protocol deviations, leaving eighty-eight in the full analysis. Mean placebo-adjusted systolic change was about −5.0 ± 2.1 mmHg. The overall diastolic difference was not significant (−1.9 ± 1.2 mmHg, P=0.12). Larger reductions in retrospectively defined responders do not replace the overall comparison. This was an extract trial, not purified allicin or proof of sulfide mediation. Manufacturer involvement and the analysis exclusions limit interpretation. [Ried 2016](https://pmc.ncbi.nlm.nih.gov/articles/PMC4734812/)
    Complete structured claim and evidence

What acts on it

  1. The aged-garlic-ried-2016 study is a preparation-specific translation comparison; its outcomes are not assigned to purified allicin.

    Allicin → Aged garlic extract in AGE at Heart 2016 source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text available; selected claim-relevant methods, results, tables/figures and limitations reviewed. Supplemental proteome and all secondary findings are not exhaustively extracted.
    experimental_model
    Editorial study-scope relationship, not experimental causation or chemical composition.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    Unsigned navigation only. Does not assert allicin content, metabolic conversion, causation or intervention equivalence.
    plain_language
    The aged-garlic-ried-2016 study is a preparation-specific translation comparison; its outcomes are not assigned to purified allicin.
    primary_references
    The effect of aged garlic extract on blood pressure and other cardiovascular risk factors in uncontrolled hypertensives: the AGE at Heart trial. | 2016 | DOI 10.2147/ibpc.s93335 | PMID 26869811 | https://pubmed.ncbi.nlm.nih.gov/26869811/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC4734812/ | https://doi.org/10.2147/ibpc.s93335
    source_locator
    Reviewed reference lines 89-89; exact primary location described in quoted passage where extracted.

    Allicin: detailed mechanisms of action (reviewed 5 October 2026) · lines 89–89

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Editorial study-scope relationship, not experimental causation or chemical composition. · source_derived_draft · unverified_draft

    **Blood pressure.** AGE at Heart tested 1.2 g/day aged garlic extract containing 1.2 mg SAC for twelve weeks. Ninety-five participants completed the trial; seven were excluded for protocol deviations, leaving eighty-eight in the full analysis. Mean placebo-adjusted systolic change was about −5.0 ± 2.1 mmHg. The overall diastolic difference was not significant (−1.9 ± 1.2 mmHg, P=0.12). Larger reductions in retrospectively defined responders do not replace the overall comparison. This was an extract trial, not purified allicin or proof of sulfide mediation. Manufacturer involvement and the analysis exclusions limit interpretation. [Ried 2016](https://pmc.ncbi.nlm.nih.gov/articles/PMC4734812/)
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.