Component
Diastolic blood pressure in the garlic trials
Diastolic blood pressure in the garlic trials. Interpret through the linked study species, preparation, exposure and measured endpoint.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
The overall diastolic difference in AGE at Heart was not significant: -1.9 +/- 1.2 mmHg, P=0.12.
Experimental context and source evidence
- evidence_access
- Primary full text available; selected claim-relevant methods, results, tables/figures and limitations reviewed. Supplemental proteome and all secondary findings are not exhaustively extracted.
- experimental_contrast
- {"intervention": "Specified aged garlic extract", "comparator": "Placebo", "endpoint": "The overall diastolic difference in AGE at Heart was not significant: -1.9 +/- 1.2 mmHg, P=0.12.", "effect_direction": "no_detected_change", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
- experimental_model
- Same 12-week trial and analysis group.
- interpretation_status
- Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
- limitations
- Preserve alongside the systolic result; not universal lack of BP effect.
- plain_language
- The overall diastolic difference in AGE at Heart was not significant: -1.9 +/- 1.2 mmHg, P=0.12.
- primary_references
- The effect of aged garlic extract on blood pressure and other cardiovascular risk factors in uncontrolled hypertensives: the AGE at Heart trial. | 2016 | DOI 10.2147/ibpc.s93335 | PMID 26869811 | https://pubmed.ncbi.nlm.nih.gov/26869811/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC4734812/ | https://doi.org/10.2147/ibpc.s93335
- source_locator
- Reviewed reference lines 89-89; exact primary location described in quoted passage where extracted.
Allicin: detailed mechanisms of action (reviewed 5 October 2026) · lines 89–89
Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Same 12-week trial and analysis group. · source_derived_draft · unverified_draft
**Blood pressure.** AGE at Heart tested 1.2 g/day aged garlic extract containing 1.2 mg SAC for twelve weeks. Ninety-five participants completed the trial; seven were excluded for protocol deviations, leaving eighty-eight in the full analysis. Mean placebo-adjusted systolic change was about −5.0 ± 2.1 mmHg. The overall diastolic difference was not significant (−1.9 ± 1.2 mmHg, P=0.12). Larger reductions in retrospectively defined responders do not replace the overall comparison. This was an extract trial, not purified allicin or proof of sulfide mediation. Manufacturer involvement and the analysis exclusions limit interpretation. [Ried 2016](https://pmc.ncbi.nlm.nih.gov/articles/PMC4734812/)
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.