{"id":"2b871f4e-4048-5f66-a50e-4dbb84e72cc7","stable_key":"c836a883-ac18-5eb2-9971-2f0b542feba8:age-systolic","predicate":"decreases_in_recorded_experiment","statement":"AGE at Heart reported an approximately 5.0 +/- 2.1 mmHg placebo-adjusted systolic reduction in the full analysis group.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"00ea2678-70d6-5c18-bf15-ece85830d56a","mechanism_event_label":"AGE at Heart reported an approximately 5.0 +/- 2.1 mmHg placebo-adjusted systolic reduction in the full analysis group.","subject":{"id":"796cbdcd-f137-5539-a095-c92a7e1267db","slug":"aged-garlic-ried-2016","display_name":"Aged garlic extract in AGE at Heart 2016","entity_type_key":"botanical"},"object":{"id":"8fc0ee41-c9a7-52d4-aebe-418a5307d96d","slug":"systolic-blood-pressure","display_name":"Systolic blood pressure","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"00ea2678-70d6-5c18-bf15-ece85830d56a","stable_key":"c836a883-ac18-5eb2-9971-2f0b542feba8:age-systolic-event","event_type":"experimental_observation","label":"AGE at Heart reported an approximately 5.0 +/- 2.1 mmHg placebo-adjusted systolic reduction in the full analysis group.","description":"**Blood pressure.** AGE at Heart tested 1.2 g/day aged garlic extract containing 1.2 mg SAC for twelve weeks. Ninety-five participants completed the trial; seven were excluded for protocol deviations, leaving eighty-eight in the full analysis. Mean placebo-adjusted systolic change was about −5.0 ± 2.1 mmHg. The overall diastolic difference was not significant (−1.9 ± 1.2 mmHg, P=0.12). Larger reductions in retrospectively defined responders do not replace the overall comparison. This was an extract trial, not purified allicin or proof of sulfide mediation. Manufacturer involvement and the analysis exclusions limit interpretation. [Ried 2016](https://pmc.ncbi.nlm.nih.gov/articles/PMC4734812/)","status":"provisional","compartment":null,"participants":[{"entity":{"id":"796cbdcd-f137-5539-a095-c92a7e1267db","slug":"aged-garlic-ried-2016","display_name":"Aged garlic extract in AGE at Heart 2016","entity_type_key":"botanical"},"role":"tested factor","stoichiometry":null,"state_label":"Specified aged garlic extract","sequence_order":0,"notes":""},{"entity":{"id":"8fc0ee41-c9a7-52d4-aebe-418a5307d96d","slug":"systolic-blood-pressure","display_name":"Systolic blood pressure","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"decrease","sequence_order":1,"notes":""},{"entity":{"id":"8c2c295d-68b3-5e62-b1a7-00fcf915e3cc","slug":"s-allylcysteine","display_name":"S-allyl-L-cysteine / SAC","entity_type_key":"small_molecule"},"role":"standardized preparation marker, not independently randomized","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text available; selected claim-relevant methods, results, tables/figures and limitations reviewed. Supplemental proteome and all secondary findings are not exhaustively extracted.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"Specified aged garlic extract\", \"comparator\": \"Placebo\", \"endpoint\": \"AGE at Heart reported an approximately 5.0 +/- 2.1 mmHg placebo-adjusted systolic reduction in the full analysis group.\", \"effect_direction\": \"decrease\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; source-derived draft.","entity":null},{"dimension":"experimental_model","value_text":"1.2 g/day AGE containing 1.2 mg SAC, 12 weeks; 88 analyzed after seven completer exclusions.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not purified allicin; selected responders are not the overall randomized comparison; no established sulfide mediator.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"AGE at Heart reported an approximately 5.0 +/- 2.1 mmHg placebo-adjusted systolic reduction in the full analysis group.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The effect of aged garlic extract on blood pressure and other cardiovascular risk factors in uncontrolled hypertensives: the AGE at Heart trial. | 2016 | DOI 10.2147/ibpc.s93335 | PMID 26869811 | https://pubmed.ncbi.nlm.nih.gov/26869811/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC4734812/ | https://doi.org/10.2147/ibpc.s93335","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 89-89; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8ac5bfb6-c1ca-5fef-ad3c-6483eeece5c4","evidence_kind":"source_excerpt","locator":"Lines 89-89","start_line":89,"end_line":89,"excerpt":"**Blood pressure.** AGE at Heart tested 1.2 g/day aged garlic extract containing 1.2 mg SAC for twelve weeks. Ninety-five participants completed the trial; seven were excluded for protocol deviations, leaving eighty-eight in the full analysis. Mean placebo-adjusted systolic change was about −5.0 ± 2.1 mmHg. The overall diastolic difference was not significant (−1.9 ± 1.2 mmHg, P=0.12). Larger reductions in retrospectively defined responders do not replace the overall comparison. This was an extract trial, not purified allicin or proof of sulfide mediation. Manufacturer involvement and the analysis exclusions limit interpretation. [Ried 2016](https://pmc.ncbi.nlm.nih.gov/articles/PMC4734812/)","model_system":"1.2 g/day AGE containing 1.2 mg SAC, 12 weeks; 88 analyzed after seven completer exclusions.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. Not a verbatim quotation from a primary paper.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"10820a6b-594a-547d-97f9-906ab4cc1d6e","stable_key":"import-c836a883-ac18-5eb2-9971-2f0b542feba8","title":"Allicin: detailed mechanisms of action (reviewed 5 October 2026)","document_type":"imported_text","citation_label":"Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication.","file_path":"","sha256":"2475d3eb681100a0a34577a47b7cba5b251df866fbd6ce795122ccabee360018","revision_id":"590df96d-2ed1-5763-b04c-bf0e096e603c","review_status":"unverified_draft","notes":""}}],"relations":[{"id":"3d67b2ca-d7bf-52bc-bdbb-3c5a158831c3","relation_type":"limits_scope_of","notes":"Distinct measured blood-pressure endpoints; not a fabricated scientific disagreement.","source_claim_id":"8451c10d-83f2-595d-be2f-da3341c083a0","source_claim_key":"c836a883-ac18-5eb2-9971-2f0b542feba8:age-diastolic-null","source_statement":"The overall diastolic difference in AGE at Heart was not significant: -1.9 +/- 1.2 mmHg, P=0.12.","target_claim_id":"2b871f4e-4048-5f66-a50e-4dbb84e72cc7","target_claim_key":"c836a883-ac18-5eb2-9971-2f0b542feba8:age-systolic","target_statement":"AGE at Heart reported an approximately 5.0 +/- 2.1 mmHg placebo-adjusted systolic reduction in the full analysis group."}],"conflicts":[],"corrections":[],"research":null}