{"id":"489a574f-cae8-5d2e-ae7c-1f744ea846b0","stable_key":"c836a883-ac18-5eb2-9971-2f0b542feba8:scope-aged-garlic-ried-2016","predicate":"has_distinct_clinical_preparation_comparison","statement":"The aged-garlic-ried-2016 study is a preparation-specific translation comparison; its outcomes are not assigned to purified allicin. ","claim_class":"identity","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"d2eead00-980b-5585-a72d-4065708eaef2","mechanism_event_label":"The aged-garlic-ried-2016 study is a preparation-specific translation comparison; its outcomes are not assigned to purified allicin. ","subject":{"id":"85c86fcf-3060-5fae-b567-4f089990ab2d","slug":"allicin","display_name":"Allicin","entity_type_key":"small_molecule"},"object":{"id":"796cbdcd-f137-5539-a095-c92a7e1267db","slug":"aged-garlic-ried-2016","display_name":"Aged garlic extract in AGE at Heart 2016","entity_type_key":"botanical"},"evidence_count":1,"mechanism_event":{"id":"d2eead00-980b-5585-a72d-4065708eaef2","stable_key":"c836a883-ac18-5eb2-9971-2f0b542feba8:scope-aged-garlic-ried-2016-event","event_type":"experimental_scope_comparison","label":"The aged-garlic-ried-2016 study is a preparation-specific translation comparison; its outcomes are not assigned to purified allicin. ","description":"**Blood pressure.** AGE at Heart tested 1.2 g/day aged garlic extract containing 1.2 mg SAC for twelve weeks. Ninety-five participants completed the trial; seven were excluded for protocol deviations, leaving eighty-eight in the full analysis. Mean placebo-adjusted systolic change was about −5.0 ± 2.1 mmHg. The overall diastolic difference was not significant (−1.9 ± 1.2 mmHg, P=0.12). Larger reductions in retrospectively defined responders do not replace the overall comparison. This was an extract trial, not purified allicin or proof of sulfide mediation. Manufacturer involvement and the analysis exclusions limit interpretation. [Ried 2016](https://pmc.ncbi.nlm.nih.gov/articles/PMC4734812/)","status":"provisional","compartment":null,"participants":[{"entity":{"id":"85c86fcf-3060-5fae-b567-4f089990ab2d","slug":"allicin","display_name":"Allicin","entity_type_key":"small_molecule"},"role":"tested factor","stoichiometry":null,"state_label":"as reported","sequence_order":0,"notes":""},{"entity":{"id":"796cbdcd-f137-5539-a095-c92a7e1267db","slug":"aged-garlic-ried-2016","display_name":"Aged garlic extract in AGE at Heart 2016","entity_type_key":"botanical"},"role":"measured outcome","stoichiometry":null,"state_label":"not_reported","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text available; selected claim-relevant methods, results, tables/figures and limitations reviewed. Supplemental proteome and all secondary findings are not exhaustively extracted.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Editorial study-scope relationship, not experimental causation or chemical composition.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Unsigned navigation only. Does not assert allicin content, metabolic conversion, causation or intervention equivalence.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The aged-garlic-ried-2016 study is a preparation-specific translation comparison; its outcomes are not assigned to purified allicin. ","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The effect of aged garlic extract on blood pressure and other cardiovascular risk factors in uncontrolled hypertensives: the AGE at Heart trial. | 2016 | DOI 10.2147/ibpc.s93335 | PMID 26869811 | https://pubmed.ncbi.nlm.nih.gov/26869811/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC4734812/ | https://doi.org/10.2147/ibpc.s93335","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 89-89; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a56e7917-58e5-5765-8668-ed44a5debe0d","evidence_kind":"source_excerpt","locator":"Lines 89-89","start_line":89,"end_line":89,"excerpt":"**Blood pressure.** AGE at Heart tested 1.2 g/day aged garlic extract containing 1.2 mg SAC for twelve weeks. Ninety-five participants completed the trial; seven were excluded for protocol deviations, leaving eighty-eight in the full analysis. Mean placebo-adjusted systolic change was about −5.0 ± 2.1 mmHg. The overall diastolic difference was not significant (−1.9 ± 1.2 mmHg, P=0.12). Larger reductions in retrospectively defined responders do not replace the overall comparison. This was an extract trial, not purified allicin or proof of sulfide mediation. Manufacturer involvement and the analysis exclusions limit interpretation. [Ried 2016](https://pmc.ncbi.nlm.nih.gov/articles/PMC4734812/)","model_system":"Editorial study-scope relationship, not experimental causation or chemical composition.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. Not a verbatim quotation from a primary paper.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"10820a6b-594a-547d-97f9-906ab4cc1d6e","stable_key":"import-c836a883-ac18-5eb2-9971-2f0b542feba8","title":"Allicin: detailed mechanisms of action (reviewed 5 October 2026)","document_type":"imported_text","citation_label":"Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication.","file_path":"","sha256":"2475d3eb681100a0a34577a47b7cba5b251df866fbd6ce795122ccabee360018","revision_id":"590df96d-2ed1-5763-b04c-bf0e096e603c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}