Component

5-cis-Lycopene / 5Z-lycopene

5-cis-Lycopene / 5Z-lycopene. Species, exposure and limitations are retained in each linked claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

Where it participates (unsigned role)

  1. Ferret BCO2 cleaved 5-cis lycopene at the 9-prime,10-prime bond to apo-10-prime-lycopenal.

    Ferret beta-carotene oxygenase 2 / BCO2 → Apo-10-prime-lycopenal source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/lycopene-research/16672231.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "135695c9d3106469d8d64ec0806ba5bf048f0f1df6f3e3cd53e838e50b960445", "start_char": 0, "end_char": 1967, "text_sha256": "135695c9d3106469d8d64ec0806ba5bf048f0f1df6f3e3cd53e838e50b960445"}
    experimental_model
    Recombinant ferret enzyme and tissue-fraction metabolism
    exposure
    5-cis, 13-cis and all-trans lycopene; iron; NAD+ or NADH
    limitations
    Ferret experiments do not quantify human cleavage flux or predict supplement response.
    nutrient_topic
    Lycopene research collection; topical membership is not evidence of a direct dietary effect. · Lycopene
    organism
    Ferret
    plain_language
    An enzyme can cut a bent lycopene molecule into a smaller signaling candidate.
    primary_references
    [lycopene-p16672231] The biochemical characterization of ferret carotene-9',10'-monooxygenase catalyzing cleavage of carotenoids in vitro and in vivo. (2006). https://pubmed.ncbi.nlm.nih.gov/16672231/ DOI: 10.1074/jbc.m512095200
    tissue_or_cell_type
    BCO2 enzyme; hepatic fractions and lung

    Lycopene: absorption, metabolism, nutrient connections and human outcomes (2026-09-17) · lines 286–297

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Recombinant ferret enzyme and tissue-fraction metabolism · source_derived_draft · unverified_draft

    ### lycopene-bco2-5cis Ferret BCO2 cleaved 5-cis lycopene at the 9-prime,10-prime bond to apo-10-prime-lycopenal. Condition category: normal nutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect. plain_language: An enzyme can cut a bent lycopene molecule into a smaller signaling candidate. organism: Ferret tissue_or_cell_type: BCO2 enzyme; hepatic fractions and lung experimental_model: Recombinant ferret enzyme and tissue-fraction metabolism limitations: Ferret experiments do not quantify human cleavage flux or predict supplement response. exposure: 5-cis, 13-cis and all-trans lycopene; iron; NAD+ or NADH evidence_span: {"source_cache": "artifacts/lycopene-research/16672231.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "135695c9d3106469d8d64ec0806ba5bf048f0f1df6f3e3cd53e838e50b960445", "start_char": 0, "end_char": 1967, "text_sha256": "135695c9d3106469d8d64ec0806ba5bf048f0f1df6f3e3cd53e838e50b960445"} [lycopene-p16672231] The biochemical characterization of ferret carotene-9',10'-monooxygenase catalyzing cleavage of carotenoids in vitro and in vivo. (2006). https://pubmed.ncbi.nlm.nih.gov/16672231/ DOI: 10.1074/jbc.m512095200
    Complete structured claim and evidence

  2. NPC1L1 antibody and ezetimibe did not significantly reduce all-E or 5Z lycopene uptake in Caco-2 cells.

    Human Niemann-Pick C1-like protein 1 / NPC1L1 → Intestinal epithelial lycopene uptake source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/lycopene-research/18641187.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7c71fd4fd3be9d14176bceb3c2104143269a788587feec232350a6f1c5913e3d", "start_char": 0, "end_char": 1557, "text_sha256": "7c71fd4fd3be9d14176bceb3c2104143269a788587feec232350a6f1c5913e3d"}
    experimental_model
    Transporter inhibition in Caco-2 cells; intestinal SR-BI transgenic mice
    exposure
    All-E and 5Z lycopene; mice received 0.25 g/kg diet for one month
    limitations
    Partial uptake inhibition is not proof of a sole transporter. Ezetimibe result is a cell assay, not a clinical drug-interaction trial.
    nutrient_topic
    Lycopene research collection; topical membership is not evidence of a direct dietary effect. · Lycopene
    organism
    Human Caco-2 cells
    plain_language
    A transporter used by other lipids was not necessary in this particular assay.
    primary_references
    [lycopene-p18641187] Lycopene absorption in human intestinal cells and in mice involves scavenger receptor class B type I but not Niemann-Pick C1-like 1. (2008). https://pubmed.ncbi.nlm.nih.gov/18641187/ DOI: 10.1093/jn/138.8.1432
    tissue_or_cell_type
    Intestinal epithelium and plasma

    Lycopene: absorption, metabolism, nutrient connections and human outcomes (2026-09-17) · lines 117–128

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Transporter inhibition in Caco-2 cells; intestinal SR-BI transgenic mice · source_derived_draft · unverified_draft

    ### lycopene-npc1l1-null NPC1L1 antibody and ezetimibe did not significantly reduce all-E or 5Z lycopene uptake in Caco-2 cells. Condition category: normal nutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect. plain_language: A transporter used by other lipids was not necessary in this particular assay. organism: Human Caco-2 cells tissue_or_cell_type: Intestinal epithelium and plasma experimental_model: Transporter inhibition in Caco-2 cells; intestinal SR-BI transgenic mice limitations: Partial uptake inhibition is not proof of a sole transporter. Ezetimibe result is a cell assay, not a clinical drug-interaction trial. exposure: All-E and 5Z lycopene; mice received 0.25 g/kg diet for one month evidence_span: {"source_cache": "artifacts/lycopene-research/18641187.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7c71fd4fd3be9d14176bceb3c2104143269a788587feec232350a6f1c5913e3d", "start_char": 0, "end_char": 1557, "text_sha256": "7c71fd4fd3be9d14176bceb3c2104143269a788587feec232350a6f1c5913e3d"} [lycopene-p18641187] Lycopene absorption in human intestinal cells and in mice involves scavenger receptor class B type I but not Niemann-Pick C1-like 1. (2008). https://pubmed.ncbi.nlm.nih.gov/18641187/ DOI: 10.1093/jn/138.8.1432
    Complete structured claim and evidence

  3. SR-BI antibody or BLT1 inhibited all-E and 5Z lycopene uptake by up to 60% in Caco-2 monolayers.

    Scavenger receptor class B type 1 / SCARB1 → Lycopene source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/lycopene-research/18641187.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7c71fd4fd3be9d14176bceb3c2104143269a788587feec232350a6f1c5913e3d", "start_char": 0, "end_char": 1557, "text_sha256": "7c71fd4fd3be9d14176bceb3c2104143269a788587feec232350a6f1c5913e3d"}
    experimental_model
    Transporter inhibition in Caco-2 cells; intestinal SR-BI transgenic mice
    exposure
    All-E and 5Z lycopene; mice received 0.25 g/kg diet for one month
    limitations
    Partial uptake inhibition is not proof of a sole transporter. Ezetimibe result is a cell assay, not a clinical drug-interaction trial.
    nutrient_topic
    Lycopene research collection; topical membership is not evidence of a direct dietary effect. · Lycopene
    organism
    Human Caco-2 cells
    plain_language
    One intestinal lipid transporter helps lycopene enter these cells.
    primary_references
    [lycopene-p18641187] Lycopene absorption in human intestinal cells and in mice involves scavenger receptor class B type I but not Niemann-Pick C1-like 1. (2008). https://pubmed.ncbi.nlm.nih.gov/18641187/ DOI: 10.1093/jn/138.8.1432
    tissue_or_cell_type
    Intestinal epithelium and plasma

    Lycopene: absorption, metabolism, nutrient connections and human outcomes (2026-09-17) · lines 104–115

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Transporter inhibition in Caco-2 cells; intestinal SR-BI transgenic mice · source_derived_draft · unverified_draft

    ### lycopene-srbi-uptake SR-BI antibody or BLT1 inhibited all-E and 5Z lycopene uptake by up to 60% in Caco-2 monolayers. Condition category: normal nutrient_topic: Lycopene research collection; topical membership is not evidence of a direct dietary effect. plain_language: One intestinal lipid transporter helps lycopene enter these cells. organism: Human Caco-2 cells tissue_or_cell_type: Intestinal epithelium and plasma experimental_model: Transporter inhibition in Caco-2 cells; intestinal SR-BI transgenic mice limitations: Partial uptake inhibition is not proof of a sole transporter. Ezetimibe result is a cell assay, not a clinical drug-interaction trial. exposure: All-E and 5Z lycopene; mice received 0.25 g/kg diet for one month evidence_span: {"source_cache": "artifacts/lycopene-research/18641187.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "7c71fd4fd3be9d14176bceb3c2104143269a788587feec232350a6f1c5913e3d", "start_char": 0, "end_char": 1557, "text_sha256": "7c71fd4fd3be9d14176bceb3c2104143269a788587feec232350a6f1c5913e3d"} [lycopene-p18641187] Lycopene absorption in human intestinal cells and in mice involves scavenger receptor class B type I but not Niemann-Pick C1-like 1. (2008). https://pubmed.ncbi.nlm.nih.gov/18641187/ DOI: 10.1093/jn/138.8.1432
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards